San Fransisco, Calif., Dec. 16, 2019 — Kindred Biosciences, Inc. (NASDAQ: KIN), a commercial-stage biopharmaceutical company focused on saving and improving the lives of pets, today unveiled positive results from its randomized, placebo-controlled laboratory pilot study of KIND-032, a fully caninized monoclonal antibody targeting interleukin-4 receptor (IL-4R), for the treatment of atopic dermatitis in dogs.
In the study, 14 laboratory dogs with clinical signs consistent with atopic dermatitis were dosed with placebo or with KIND-032 at two different doses. The CADESI scores were assessed by board-certified veterinary dermatologists who were blinded to treatment assignments. The study demonstrated that KindredBio’s antibody was well-tolerated. Although the study was a single-dose study designed primarily to assess safety and pharmacokinetics, evidence of positive efficacy and dose response was observed at Week 1, as measured by CADESI-04. A second pilot study to further assess efficacy and dosing is planned for 2020.
“The results exceeded our expectations for this small, single-dose study,” said KindredBio’s Chief Executive Officer, Richard Chin, M.D. “This is another in a string of positive results for our biologics candidates, and brings us closer to our goal of becoming a leader in canine dermatitis. We are particularly pleased with this program’s rapid progress, which is also surpassing our expectations.”
The IL-4 pathway is a key driver of the inflammation that underlies atopic dermatitis and several other allergic diseases. Unlike the company’s anti-IL-4/IL-13 SINK molecule, which binds to IL-4 and IL-13 circulating in blood, KIND-032 binds to the IL-4 receptor on the surface of immune cells. As a result of blockade of IL-4R, it prevents both IL-4 and IL-13 signaling pathways. The efficacy profiles, the subgroups of patients who respond to the biologics, and the ability to combine the biologics with other therapeutics may therefore differ between the two molecules.
Atopic dermatitis is the leading reason owners take their dog to the veterinarian, and the current market is over $700 million annually.
Forward-Looking Statements
This press release contains forward-looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. All statements contained in this press release that do not relate to matters of historical fact should be considered forward-looking statements, including, but not limited to, statements regarding our expectations about the trials, regulatory approval, manufacturing, distribution and commercialization of our current and future product candidates, and statements regarding our anticipated revenues, expenses, margins, profits and use of cash.
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For a further description of these risks and other risks that we face, please see the risk factors described in our filings with the U.S. Securities and Exchange Commission (the SEC), including the risk factors discussed under the caption “Risk Factors” in our Annual Report on Form 10-K and any subsequent updates that may be contained in our Quarterly Reports on Form 10-Q filed with the SEC. As a result of the risks described above and in our filings with the SEC, actual results may differ materially from those indicated by the forward-looking statements made in this press release. Forward-looking statements contained in this press release speak only as of the date of this press release and we undertake no obligation to update or revise these statements, except as may be required by law.
The results stated in this press release have not been reviewed by the United States Department of Agriculture Center for Veterinary Biologics.
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