{"id":36090,"date":"2025-08-13T15:23:34","date_gmt":"2025-08-13T15:23:34","guid":{"rendered":"https:\/\/todaysveterinarypractice.com\/?p=36090"},"modified":"2025-12-12T18:48:52","modified_gmt":"2025-12-12T18:48:52","slug":"urinary-incontinence-in-canine-patients","status":"publish","type":"post","link":"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/urology-renal-medicine\/urinary-incontinence-in-canine-patients\/","title":{"rendered":"Diagnosing and Managing Urinary Incontinence in Canine Patients"},"content":{"rendered":"<p><div class=\"su-spacer\" style=\"height:10px\"><\/div><div class=\"su-note\"  style=\"border-color:#d8d8d8;border-radius:3px;-moz-border-radius:3px;-webkit-border-radius:3px;\"><div class=\"su-note-inner su-u-clearfix su-u-trim\" style=\"background-color:#f2f2f2;border-color:#ffffff;color:#333333;border-radius:3px;-moz-border-radius:3px;-webkit-border-radius:3px;\"><strong>Abstract<\/strong><\/p>\n<p>Urinary incontinence can profoundly impact quality of life for dogs and their caretakers. This article provides an overview of the common causes of urinary incontinence and outlines a logical approach for evaluation and management of dogs with this condition.<\/p>\n<p><strong>Take-Home Points<\/strong><\/p>\n<ul>\n<li>Urinary incontinence (UI) is a common condition in dogs and is particularly prevalent in older females.<\/li>\n<li>Most dogs with UI have a storage disorder, meaning that urine is not retained appropriately within the urinary bladder.<\/li>\n<li>Congenital defects such as ectopic ureter are the most common cause of UI in juveniles.<\/li>\n<li>Selection of an appropriate medical therapy requires differentiation of UI due to a storage disorder from UI due to a voiding disorder.<\/li>\n<li>Interventions\u2014cystoscopic or surgical\u2014may be necessary for the effective amelioration of some causes of UI.<\/li>\n<li>Prompt referral for specialized diagnostics or treatments, when indicated, is expected to improve long-term outcomes for affected patients.<\/div><\/div><\/li>\n<\/ul>\n<p class=\"p1\"><span class=\"s1\">Urinary incontinence (UI), defined as the passive and involuntary leakage of urine, must be differentiated from periuria (the conscious voiding of urine in inappropriate locations).<sup>1<\/sup> In some instances, complications related to UI such as urinary tract infection (UTI) can cause confusion, and care must be taken to establish a reliable clinical picture. The prevalence of UI in dogs is unclear, although it is well established that spayed female dogs are predisposed.<sup>2-6<\/sup> The severity is variable, with clinical signs ranging from an occasional damp spot on bedding to persistent dripping throughout the day and night. However, even low-grade UI can impact patient wellbeing and cause substantial distress to caretakers<sup>2,3,7<\/sup>; it is therefore important to promptly identify the cause and offer appropriate management options.<\/span><\/p>\n<h2 class=\"p2\">Normal Voiding<\/h2>\n<p class=\"p1\"><span class=\"s1\">Control of urination is complex; it includes a storage phase during which the bladder relaxes as it slowly fills and a voiding phase in which urine is deliberately released.<sup>1<\/sup> Considered simplistically, the bladder acts as a reservoir for urine and the urethra functions as a sphincter; normal voiding requires coordinated contraction of the former and relaxation of the latter and is controlled by both local reflexes and inputs from higher centers. In dogs with UI, these normal processes are disrupted by mechanical or functional disorders. <\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Differentiating storage disorders from voiding disorders relies on determination of the postvoid residual volume (PVRV; i.e., the amount of urine remaining in the bladder after voluntary<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">urination). This is routinely calculated using 2D ultrasonographic measurements of bladder size <strong>(<\/strong><\/span><strong><span class=\"s2\">BOX 1<\/span><\/strong><span class=\"s1\"><strong>)<\/strong>. A normal PVRV is defined as &lt;\u20091 mL\/kg, while a PVRV &gt;\u20093 mL\/kg indicates urine retention; intermediate values are regarded as inconclusive.<sup>1<\/sup> It can be helpful to determine PVRV immediately after a routine walk with the owner, as (in the authors\u2019 experience) the stress of being in the clinic and observed by strangers may inhibit normal voiding behaviors.<\/span><\/p>\n<div class=\"su-box su-box-style-default\" id=\"\" style=\"border-color:#003d45;border-radius:3px;\"><div class=\"su-box-title\" style=\"background-color:#007078;color:#FFFFFF;border-top-left-radius:1px;border-top-right-radius:1px\">BOX 1 Calculation of Postvoid Residual Volume (PVRV) Using 2D Ultrasonography<\/div><div class=\"su-box-content su-u-clearfix su-u-trim\" style=\"border-bottom-left-radius:1px;border-bottom-right-radius:1px\"><\/p>\n<ul>\n<li>Postvoid residual volume (PVRV)\u2009=\u2009Length (a)\u2009\u00d7\u2009height (b)\u2009\u00d7\u2009width (c)\u2009\u00d7\u20090.52\u2009\/\u2009weight (kg)<\/li>\n<li>Maximal dimensions (in cm) should be used for each measurement <strong>(FIGURE A AND B)<\/strong>.<\/li>\n<li>If the bladder is too large to be effectively captured in the image, dimensions can be approximated.<\/li>\n<li>For the patient shown in <strong>FIGURES A AND B<\/strong>, weighing 26.5 kg (58.4 lb), the estimated PVRV is (10.5\u2009\u00d7\u20096.8\u2009\u00d7\u200910.8\u2009\u00d7\u20090.52)\u2009\/\u200926.5\u2009=\u200915.1 mL\/kg.<\/li>\n<\/ul>\n<p><div class=\"su-image-carousel  su-image-carousel-has-spacing su-image-carousel-crop su-image-carousel-crop-1-1 su-image-carousel-has-lightbox su-image-carousel-has-outline su-image-carousel-adaptive su-image-carousel-slides-style-default su-image-carousel-controls-style-dark su-image-carousel-align-center\" style=\"max-width:70%\" data-flickity-options='{\"groupCells\":true,\"cellSelector\":\".su-image-carousel-item\",\"adaptiveHeight\":false,\"cellAlign\":\"left\",\"prevNextButtons\":true,\"pageDots\":false,\"autoPlay\":5000,\"imagesLoaded\":true,\"contain\":true,\"selectedAttraction\":0.025,\"friction\":0.28}' id=\"su_image_carousel_69d695f9b0e43\"><div class=\"su-image-carousel-item\"><div class=\"su-image-carousel-item-content\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Box1A.jpg\" target=\"_blank\" rel=\"noopener noreferrer\" data-caption=\"\"><img fetchpriority=\"high\" decoding=\"async\" width=\"768\" height=\"537\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Box1A-768x537.jpg\" class=\"\" alt=\"\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Box1A-768x537.jpg 768w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Box1A-300x210.jpg 300w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Box1A.jpg 818w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/><span><\/span><\/a><\/div><\/div><div class=\"su-image-carousel-item\"><div class=\"su-image-carousel-item-content\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Box1B.png\" target=\"_blank\" rel=\"noopener noreferrer\" data-caption=\"\"><img decoding=\"async\" width=\"768\" height=\"506\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Box1B-768x506.png\" class=\"\" alt=\"\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Box1B-768x506.png 768w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Box1B-300x198.png 300w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Box1B.png 872w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/><span><\/span><\/a><\/div><\/div><\/div><script id=\"su_image_carousel_69d695f9b0e43_script\">if(window.SUImageCarousel){setTimeout(function() {window.SUImageCarousel.initGallery(document.getElementById(\"su_image_carousel_69d695f9b0e43\"))}, 0);}var su_image_carousel_69d695f9b0e43_script=document.getElementById(\"su_image_carousel_69d695f9b0e43_script\");if(su_image_carousel_69d695f9b0e43_script){su_image_carousel_69d695f9b0e43_script.parentNode.removeChild(su_image_carousel_69d695f9b0e43_script);}<\/script> <\/div><\/div>\n<h2 class=\"p2\">Storage Disorders<\/h2>\n<p class=\"p1\"><span class=\"s1\">Dogs with storage disorders have a PVRV &lt;\u20091\u00a0mL\/kg but are unable to retain urine reliably within the urinary bladder. Causes may be divided into non-neurogenic and neurogenic, with the former being most likely <strong>(<\/strong><\/span><strong><span class=\"s2\">FIGURE 1<\/span><\/strong><span class=\"s1\"><strong>)<\/strong>.<sup>1,2,5<\/sup> <\/span><\/p>\n<p><a href=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig1.jpg\"><img decoding=\"async\" class=\"aligncenter size-full wp-image-36285\" src=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig1.jpg\" alt=\"\" width=\"1936\" height=\"1637\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig1.jpg 1936w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig1-300x254.jpg 300w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig1-1024x866.jpg 1024w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig1-768x649.jpg 768w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig1-1536x1299.jpg 1536w\" sizes=\"(max-width: 1936px) 100vw, 1936px\" \/><\/a><\/p>\n<p class=\"p1\"><span class=\"s1\">Common non-neurogenic conditions include urethral sphincter mechanism incompetence (USMI) and congenital issues such as ectopic ureter. UTI also falls in this category, although affected dogs often have a concurrent contributory disorder. Less common considerations include pelvic bladder\/short urethra, idiopathic detrusor instability, bladder fibrosis, and fistulae (ureterovaginal, urethrovaginal, urethrorectal). Depending on the underlying cause, dogs with non-neurogenic storage disorders may also consciously urinate normal volumes in appropriate locations. <\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Neurogenic conditions include problems affecting the sacrocaudal spinal cord or cauda equina, such as intervertebral disk herniation, trauma, and neoplasia.<sup>8<\/sup><\/span><\/p>\n<h3 class=\"p3\">Urethral Sphincter Mechanism Incompetence<\/h3>\n<p class=\"p1\"><span class=\"s1\">Dogs with USMI usually void small urine puddles while resting but are continent when active and engaged. Establishing a diagnosis of USMI requires exclusion of other likely possibilities. However, as this condition is the most common cause of UI in ovariectomized middle-aged female dogs, it is reasonable to make a presumptive diagnosis in these patients and assess the response to therapy <strong>(<\/strong><\/span><strong><span class=\"s2\">TABLE 1<\/span><\/strong><span class=\"s1\"><strong>)<\/strong> before considering more advanced diagnostics <strong>(<\/strong><\/span><strong><span class=\"s2\">CASE\u00a0EXAMPLE<\/span><\/strong><span class=\"s1\"><strong>)<\/strong>. <\/span><\/p>\n<table class=\"tg\" style=\"border-collapse: collapse;border-spacing: 0;width: 678px\">\n<colgroup>\n<col style=\"width: 100px\" \/>\n<col style=\"width: 136px\" \/>\n<col style=\"width: 160px\" \/>\n<col style=\"width: 101px\" \/>\n<col style=\"width: 181px\" \/><\/colgroup>\n<thead>\n<tr>\n<th style=\"background-color: #fff;color: #3ab0c8;font-family: Arial, sans-serif;font-size: 14px;font-weight: normal;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: top;border: 1px solid inherit\" colspan=\"5\"><span style=\"color: #3ab0c8\">Table 1<\/span>\u00a0<span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Drugs Routinely Used in the Management of Canine Urinary Incontinence<\/span><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"background-color: #3ab0c8;color: #fff;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #fff\">Name<\/span><\/td>\n<td style=\"background-color: #3ab0c8;color: #fff;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #fff\">Dose<\/span><\/td>\n<td style=\"background-color: #3ab0c8;color: #fff;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #fff\">Drug Class and<\/span><br \/>\n<span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #fff\">Mechanism of Action<\/span><\/td>\n<td style=\"background-color: #3ab0c8;color: #fff;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #fff\">Indication<\/span><\/td>\n<td style=\"background-color: #3ab0c8;color: #fff;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #fff\">Comments<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Acepromazine<\/span><\/td>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">0.5\u20132.2 mg\/kg PO q6\u20138h<\/span><\/td>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Phenothiazine derivative;<\/span><br \/>\n<span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">skeletal muscle relaxant<\/span><\/td>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Functional outflow obstruction<\/span><\/td>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Adverse effects include sedation and hypotension.<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"background-color: #fff;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Alprazolam<\/span><\/td>\n<td style=\"background-color: #fff;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">0.02\u20130.1 mg\/kg PO q12h<\/span><\/td>\n<td style=\"background-color: #fff;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Benzodiazepine;<\/span><br \/>\n<span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">skeletal muscle relaxant<\/span><\/td>\n<td style=\"background-color: #fff;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Functional outflow obstruction<\/span><\/td>\n<td style=\"background-color: #fff;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal\">Schedule IV controlled substance<\/span><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">. Adverse effects include sedation and polyphagia.<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Bethanechol<\/span><\/td>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">2.5\u201325 mg\/dog PO q8\u201324h<\/span><\/td>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Muscarinic cholinergic agonist; stimulates detrusor contraction<\/span><\/td>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Detrusor atony<\/span><\/td>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Adverse effects include salivation and diarrhea.<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"background-color: #fff;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Dantrolene sodium<\/span><\/td>\n<td style=\"background-color: #fff;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">0.3\u20130.9 mg\/kg PO q8h<\/span><\/td>\n<td style=\"background-color: #fff;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Postsynaptic muscle relaxant; skeletal muscle relaxant<\/span><\/td>\n<td style=\"background-color: #fff;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Functional outflow obstruction<\/span><\/td>\n<td style=\"background-color: #fff;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Adverse effects include sedation, weakness, and hepatotoxicity.<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Diazepam<\/span><\/td>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">0.02\u20130.25 mg\/kg PO q8h<\/span><\/td>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Benzodiazepine; skeletal muscle relaxant<\/span><\/td>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Functional outflow obstruction<\/span><\/td>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal\">Schedule IV controlled substance<\/span><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">. Adverse effects include sedation. Give 30 minutes before walking.<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"background-color: #fff;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Diethylstilbestrol<\/span><\/td>\n<td style=\"background-color: #fff;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">0.1\u20131.0 mg PO q24h \u00d7 5 days, then weekly or as needed<\/span><\/td>\n<td style=\"background-color: #fff;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Estrogen; increased sphincter responsiveness to norepinephrine, also inhibits gonadotropin-releasing hormone production<\/span><\/td>\n<td style=\"background-color: #fff;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">USMI (females)<\/span><\/td>\n<td style=\"background-color: #fff;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal\">Only (unapproved) compounded products available in the United States<\/span><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">. Adverse effects include mammary and vulval swelling; myelosuppression may occur with incautious dosing.<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Estriol<\/span><\/td>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">2 mg PO q24h \u00d7 14 days, then reduce to 1 mg PO q24<\/span><\/td>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Estrogen; increased sphincter responsiveness to norepinephrine, also inhibits gonadotropin-releasing hormone production<\/span><\/td>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">USMI (females)<\/span><\/td>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Some dogs can be maintained on every-other-day dosing.<\/span><br \/>\n<span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Adverse effects include mammary and vulval enlargement.<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"background-color: #fff;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Lorazepam<\/span><\/td>\n<td style=\"background-color: #fff;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">0.02\u20130.2 mg\/kg PO q8\u201312h<\/span><\/td>\n<td style=\"background-color: #fff;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Benzodiazepine; skeletal muscle relaxant<\/span><\/td>\n<td style=\"background-color: #fff;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Functional outflow obstruction<\/span><\/td>\n<td style=\"background-color: #fff;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal\">Schedule IV controlled substance<\/span><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">. Adverse effects include sedation and behavioral changes.<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Methyltestosterone<\/span><\/td>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">0.5 mg\/kg PO q24h<\/span><\/td>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Androgen; actual mechanism unclear<\/span><\/td>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">USMI (males)<\/span><\/td>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal\">Only (unapproved) compounded products available<\/span><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">. Prolonged use is not advisable; patient with a positive response should be transitioned to testosterone cypionate.<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"background-color: #fff;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Oxybutynin<\/span><\/td>\n<td style=\"background-color: #fff;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">0.2\u20130.3 mg\/kg PO q8\u201312h<\/span><\/td>\n<td style=\"background-color: #fff;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Antimuscarinic and antispasmodic; reduces frequency of bladder contractions through parasympathetic blockade<\/span><\/td>\n<td style=\"background-color: #fff;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Detrusor instability<\/span><\/td>\n<td style=\"background-color: #fff;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Adverse effects include urine retention and hypersalivation.<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Phenoxybenzamine<\/span><\/td>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">0.5 mg\/kg PO q24h or<\/span><br \/>\n<span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">0.25 mg\/kg PO q12h<\/span><\/td>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal\">\u03b1<\/span><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">-Adrenergic antagonist; smooth muscle stimulant<\/span><\/td>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Functional outflow obstruction<\/span><\/td>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Adverse effects include hypotension and weakness.<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"background-color: #fff;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Phenylpropanolamine<\/span><\/td>\n<td style=\"background-color: #fff;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">2 mg\/kg PO q8\u201312h<\/span><br \/>\n<span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">or 2-4 mg\/kg PO q24h extended-release formulation<\/span><\/td>\n<td style=\"background-color: #fff;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal\">\u03b1<\/span><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">-Adrenergic agonist; smooth muscle stimulant<\/span><\/td>\n<td style=\"background-color: #fff;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">USMI<\/span><\/td>\n<td style=\"background-color: #fff;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Adverse effects include hypertension and restlessness.<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Prazosin<\/span><\/td>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">0.5\u20133 mg PO q8\u201312h<\/span><\/td>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal\">\u03b1<\/span><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">-Adrenergic antagonist; smooth muscle stimulant<\/span><\/td>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Functional outflow obstruction<\/span><\/td>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Adverse effects include hypotension and weakness.<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"background-color: #fff;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Tamsulosin hydrochloride<\/span><\/td>\n<td style=\"background-color: #fff;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">0.4\u20130.8 mg\/dog PO q24h<\/span><\/td>\n<td style=\"background-color: #fff;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal\">\u03b1<\/span><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">-Adrenergic antagonist; smooth muscle stimulant<\/span><\/td>\n<td style=\"background-color: #fff;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Functional outflow obstruction<\/span><\/td>\n<td style=\"background-color: #fff;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Adverse effects include hypotension and weakness.<\/span><br \/>\n<span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Dose may be cautiously increased to 3 times a day if necessary.<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Testosterone cypionate<\/span><\/td>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">2.2 mg\/kg IM q4\u20138 weeks<\/span><\/td>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Androgen; actual mechanism unclear<\/span><\/td>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">USMI (males)<\/span><\/td>\n<td style=\"background-color: #eaf3f6;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: center;vertical-align: middle;border: 1px solid inherit\"><span style=\"font-weight: normal;font-style: normal\">Only (unapproved) compounded products available in the United States<\/span><span style=\"font-weight: normal;font-style: italic\">.<\/span>\u00a0<span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">Adverse effects include aggression and prostatic hyperplasia.<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"background-color: #fff;color: #58595b;font-family: Arial, sans-serif;font-size: 14px;overflow: hidden;padding: 10px 5px;text-align: left;vertical-align: middle;border: 1px solid inherit\" colspan=\"5\"><span style=\"font-weight: normal;font-style: normal;text-decoration: none;color: #58595b\">USMI = urethral sphincter mechanism incompetence<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"p1\"><span class=\"s1\">The authors routinely prescribe estriol initially as this is usually well tolerated.<sup>2,9,10<\/sup> Phenylpropanolamine can be added to the treatment plan if continence is not achieved within 3 to 4 weeks.<sup>11-13<\/sup> Refractory cases may benefit from cystoscopic urethral bulking; this procedure requires general anesthesia but routinely provides &gt;\u20099 months of improved continence.<sup>1,14,15<\/sup> USMI in male dogs should be initially treated with phenylpropanolamine; androgens may be considered if this drug is not adequately effective.<sup>16<\/sup> A permanent artificial urethral sphincter is an option for both male and female dogs in which standard therapy fails. These devices substantially improve continence in most dogs; however, significant complications such as urethral stricture have been reported in up to 30% of patients.<sup>17-19<\/sup><\/span><\/p>\n<p><div class=\"su-box su-box-style-default\" id=\"\" style=\"border-color:#003d45;border-radius:3px;\"><div class=\"su-box-title\" style=\"background-color:#007078;color:#FFFFFF;border-top-left-radius:1px;border-top-right-radius:1px\">Case Example: Urinary Incontinence in a 5-Year-Old Dog<\/div><div class=\"su-box-content su-u-clearfix su-u-trim\" style=\"border-bottom-left-radius:1px;border-bottom-right-radius:1px\"><strong>History<\/strong><\/p>\n<p>A 5-year-old female spayed Doberman pinscher presented for additional management of urinary incontinence (UI). The owners reported that they first noticed small (hand-sized) wet spots on the dog\u2019s bedding about 4 months earlier. These were initially uncommon but became an every-other-day or daily occurrence. Leakage only seemed to occur when the dog was resting. There were no other changes in urinary habits, and the dog continued to void appropriately outside 4 to 5 times a day. This dog was spayed at 6 months of age, prior to her first heat, and was otherwise well. On initial evaluation by her primary care veterinarian approximately 3 months after UI was first noted, the dog\u2019s physical examination was unremarkable. A urine sample collected via cystocentesis had a specific gravity of 1.038 and pH of 6.5, with an unremarkable sediment examination. Based on these findings, the dog was presumptively diagnosed with urethral sphincter mechanism incompetence (USMI) and started on extended-release phenylpropanolamine at 2.1 mg\/kg PO q24h. The owners noted some improvement in continence after 2 weeks but still routinely found wet spots on the bedding. Estriol was subsequently started at 2 mg PO q24h for 14 days, then 1 mg PO q24h, but appeared to provide minimal benefit and was subsequently discontinued. The dog was referred to an internist for further evaluation.<\/p>\n<p><strong>Diagnostic Findings<\/strong><\/p>\n<p>The dog\u2019s physical examination was unremarkable. There was no evidence of urine scald or perivulvular dermatitis. Results of a CBC and serum biochemical profile were unremarkable. Transabdominal ultrasonography showed normal kidneys and a midsized urinary bladder. No masses or stones were noted, and both ureteral openings appeared to be within the trigone. The dog was observed to urinate normally when outside and had a postvoid residual volume of 0.4 mL\/kg. Findings on routine urinalysis were similar to those reported before, and a quantified urine culture was negative. The dog was anesthetized a few days later for cystourethroscopy performed with a 2.7-mm 30\u00b0 rigid pediatric cystoscope with the patient in dorsal recumbency. The vestibule was unremarkable, but a vestibulovaginal septal remnant was noted spanning the vaginal opening and was ablated with a diode laser <strong>(FIGURE A)<\/strong>.<\/p>\n<div class=\"su-image-carousel  su-image-carousel-has-spacing su-image-carousel-crop su-image-carousel-crop-1-1 su-image-carousel-has-lightbox su-image-carousel-has-outline su-image-carousel-adaptive su-image-carousel-slides-style-default su-image-carousel-controls-style-dark su-image-carousel-align-center\" style=\"max-width:70%\" data-flickity-options='{\"groupCells\":true,\"cellSelector\":\".su-image-carousel-item\",\"adaptiveHeight\":false,\"cellAlign\":\"left\",\"prevNextButtons\":true,\"pageDots\":false,\"autoPlay\":5000,\"imagesLoaded\":true,\"contain\":true,\"selectedAttraction\":0.025,\"friction\":0.28}' id=\"su_image_carousel_69d695f9b1600\"><div class=\"su-image-carousel-item\"><div class=\"su-image-carousel-item-content\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_CaseExFigA1.jpg\" target=\"_blank\" rel=\"noopener noreferrer\" data-caption=\"Figure A. Cystoscopic images of a 5-year-old spayed female Doberman pinscher with a 4-month history of intermittent urinary incontinence. The dog is in dorsal recumbency for the procedure. (1) A vestibulovaginal septal remnant (blue asterisk) spans the vaginal opening (arrowheads). A hydrophilic guidewire has been placed through the left side of the vaginal opening to enable the endoscopist to reliably differentiate a septal remnant from a bifid vagina. The urethral papilla is visible near the top of the image (white asterisk).\"><img loading=\"lazy\" decoding=\"async\" width=\"768\" height=\"701\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_CaseExFigA1-768x701.jpg\" class=\"\" alt=\"\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_CaseExFigA1-768x701.jpg 768w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_CaseExFigA1-300x274.jpg 300w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_CaseExFigA1.jpg 867w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/><span>Figure A. Cystoscopic images of a 5-year-old spayed female Doberman pinscher with a 4-month history of intermittent urinary incontinence. The dog is in dorsal recumbency for the procedure. (1) A vestibulovaginal septal remnant (blue asterisk) spans the vaginal opening (arrowheads). A hydrophilic guidewire has been placed through the left side of the vaginal opening to enable the endoscopist to reliably differentiate a septal remnant from a bifid vagina. The urethral papilla is visible near the top of the image (white asterisk).<\/span><\/a><\/div><\/div><div class=\"su-image-carousel-item\"><div class=\"su-image-carousel-item-content\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_CaseExFigA2.png\" target=\"_blank\" rel=\"noopener noreferrer\" data-caption=\"Figure A2. A diode laser (arrowheads) is used to bisect the vestibulovaginal\"><img loading=\"lazy\" decoding=\"async\" width=\"768\" height=\"697\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_CaseExFigA2-768x697.png\" class=\"\" alt=\"\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_CaseExFigA2-768x697.png 768w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_CaseExFigA2-300x272.png 300w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_CaseExFigA2.png 871w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/><span>Figure A2. A diode laser (arrowheads) is used to bisect the vestibulovaginal<\/span><\/a><\/div><\/div><\/div><script id=\"su_image_carousel_69d695f9b1600_script\">if(window.SUImageCarousel){setTimeout(function() {window.SUImageCarousel.initGallery(document.getElementById(\"su_image_carousel_69d695f9b1600\"))}, 0);}var su_image_carousel_69d695f9b1600_script=document.getElementById(\"su_image_carousel_69d695f9b1600_script\");if(su_image_carousel_69d695f9b1600_script){su_image_carousel_69d695f9b1600_script.parentNode.removeChild(su_image_carousel_69d695f9b1600_script);}<\/script>\n<p>The urethral walls were smooth and pink; urethral length was somewhat shorter than expected at 7 cm. The trigone was clearly defined and was easily traversed with the cystoscope. The urinary bladder wall was unremarkable, with no stones or masses. Both ureteral openings were identified and appeared normal. A urethral bulking agent containing cross-linked porcine gelatin (VetFoam; BioChange, <a href=\"http:\/\/biochange.life\" target=\"_blank\" rel=\"noopener\">biochange.life<\/a>) was injected at 3 sites within the proximal urethra, approximately 1 cm caudal to the trigone. About 1.3 mL of bulking agent was injected at each site, with the 3 blebs positioned at regular intervals around the circumference of the urethra <strong>(FIGURE B)<\/strong>. The dog was discharged with a 3-day course of carprofen (2 mg\/kg PO q12h), and the owner was instructed to discontinue phenylpropanolamine. Four weeks postprocedure, the dog was fully continent and able to void comfortably.<\/p>\n<div class=\"su-image-carousel  su-image-carousel-has-spacing su-image-carousel-crop su-image-carousel-crop-1-1 su-image-carousel-has-lightbox su-image-carousel-has-outline su-image-carousel-adaptive su-image-carousel-slides-style-default su-image-carousel-controls-style-dark su-image-carousel-align-center\" style=\"max-width:70%\" data-flickity-options='{\"groupCells\":true,\"cellSelector\":\".su-image-carousel-item\",\"adaptiveHeight\":false,\"cellAlign\":\"left\",\"prevNextButtons\":true,\"pageDots\":false,\"autoPlay\":5000,\"imagesLoaded\":true,\"contain\":true,\"selectedAttraction\":0.025,\"friction\":0.28}' id=\"su_image_carousel_69d695f9b1f0a\"><div class=\"su-image-carousel-item\"><div class=\"su-image-carousel-item-content\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_CaseExFigB1.png\" target=\"_blank\" rel=\"noopener noreferrer\" data-caption=\"Figure B. Cystoscopic images of the same dog as in Figure A. (1) The transition from proximal urethra to urinary bladder on initial examination.\"><img loading=\"lazy\" decoding=\"async\" width=\"572\" height=\"552\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_CaseExFigB1.png\" class=\"\" alt=\"\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_CaseExFigB1.png 572w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_CaseExFigB1-300x290.png 300w\" sizes=\"(max-width: 572px) 100vw, 572px\" \/><span>Figure B. Cystoscopic images of the same dog as in Figure A. (1) The transition from proximal urethra to urinary bladder on initial examination.<\/span><\/a><\/div><\/div><div class=\"su-image-carousel-item\"><div class=\"su-image-carousel-item-content\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_CaseExFigB2.png\" target=\"_blank\" rel=\"noopener noreferrer\" data-caption=\"Figure B2. A 22-gauge flexible endoscopic needle (arrowhead) is positioned against the urethral mucosa approximately 1 cm caudal to the trigone.\"><img loading=\"lazy\" decoding=\"async\" width=\"572\" height=\"553\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_CaseExFigB2.png\" class=\"\" alt=\"\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_CaseExFigB2.png 572w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_CaseExFigB2-300x290.png 300w\" sizes=\"(max-width: 572px) 100vw, 572px\" \/><span>Figure B2. A 22-gauge flexible endoscopic needle (arrowhead) is positioned against the urethral mucosa approximately 1 cm caudal to the trigone.<\/span><\/a><\/div><\/div><div class=\"su-image-carousel-item\"><div class=\"su-image-carousel-item-content\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_CaseExFigB3.png\" target=\"_blank\" rel=\"noopener noreferrer\" data-caption=\"Figure B3. Injection of cross-linked gelatin into the mucosa. A small white bleb (arrowhead) is evident.\"><img loading=\"lazy\" decoding=\"async\" width=\"572\" height=\"551\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_CaseExFigB3.png\" class=\"\" alt=\"\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_CaseExFigB3.png 572w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_CaseExFigB3-300x289.png 300w\" sizes=\"(max-width: 572px) 100vw, 572px\" \/><span>Figure B3. Injection of cross-linked gelatin into the mucosa. A small white bleb (arrowhead) is evident.<\/span><\/a><\/div><\/div><div class=\"su-image-carousel-item\"><div class=\"su-image-carousel-item-content\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_CaseExFigB4.png\" target=\"_blank\" rel=\"noopener noreferrer\" data-caption=\"Figure B4. The second bleb is injected on the other side of the urethra; a small amount of hemorrhage is noted from the first bleb.\"><img loading=\"lazy\" decoding=\"async\" width=\"575\" height=\"548\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_CaseExFigB4.png\" class=\"\" alt=\"\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_CaseExFigB4.png 575w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_CaseExFigB4-300x286.png 300w\" sizes=\"(max-width: 575px) 100vw, 575px\" \/><span>Figure B4. The second bleb is injected on the other side of the urethra; a small amount of hemorrhage is noted from the first bleb.<\/span><\/a><\/div><\/div><div class=\"su-image-carousel-item\"><div class=\"su-image-carousel-item-content\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_CaseExFigB5.png\" target=\"_blank\" rel=\"noopener noreferrer\" data-caption=\"Figure B5. Large white bleb is evident at the end of the second injection.\"><img loading=\"lazy\" decoding=\"async\" width=\"572\" height=\"548\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_CaseExFigB5.png\" class=\"\" alt=\"\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_CaseExFigB5.png 572w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_CaseExFigB5-300x287.png 300w\" sizes=\"(max-width: 572px) 100vw, 572px\" \/><span>Figure B5. Large white bleb is evident at the end of the second injection.<\/span><\/a><\/div><\/div><div class=\"su-image-carousel-item\"><div class=\"su-image-carousel-item-content\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_CaseExFigB6.png\" target=\"_blank\" rel=\"noopener noreferrer\" data-caption=\"Figure B6. The appearance of the trigone at the end of the procedure; note that the urethral lumen (arrowheads) is now essentially occluded by expanded mucosa.\"><img loading=\"lazy\" decoding=\"async\" width=\"573\" height=\"555\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_CaseExFigB6.png\" class=\"\" alt=\"\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_CaseExFigB6.png 573w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_CaseExFigB6-300x291.png 300w\" sizes=\"(max-width: 573px) 100vw, 573px\" \/><span>Figure B6. The appearance of the trigone at the end of the procedure; note that the urethral lumen (arrowheads) is now essentially occluded by expanded mucosa.<\/span><\/a><\/div><\/div><\/div><script id=\"su_image_carousel_69d695f9b1f0a_script\">if(window.SUImageCarousel){setTimeout(function() {window.SUImageCarousel.initGallery(document.getElementById(\"su_image_carousel_69d695f9b1f0a\"))}, 0);}var su_image_carousel_69d695f9b1f0a_script=document.getElementById(\"su_image_carousel_69d695f9b1f0a_script\");if(su_image_carousel_69d695f9b1f0a_script){su_image_carousel_69d695f9b1f0a_script.parentNode.removeChild(su_image_carousel_69d695f9b1f0a_script);}<\/script>\n<p><strong>Discussion<\/strong><\/p>\n<p>This dog\u2019s history is very consistent with USMI. This case is likely due to a combination of diminished urethral tone secondary to ovariohysterectomy and a somewhat short urethra. Although many dogs respond well to medical management, some experience adverse effects or have limited improvement. Urethral bulking agents are excellent options for female dogs with refractory USMI, with response rates greater than 90% reported.1 Patients should be screened for UTI prior to administration of a bulking agent. As urethral bulking agents are delivered through a rigid scope, this treatment option is not routinely performed in males. However, bulking agents can be injected into the distal urethra with a rigid scope in large males or via a perineal approach in smaller individuals. Vestibulovaginal septal remnants may be incidental and unrelated to lower urinary tract disease, but they sometimes distort the urethral papilla and have been associated with recurrent urinary tract infection.2 The authors routinely ablate these during cystoscopic examinations in case they are contributing to clinical problems. The urethral bulking agent used in this case is expected to slowly dissipate within a year, at which time the incontinence may recur. In some patients, restarting phenylpropanolamine may be sufficient to achieve continence for a few more months. However, owners should be counseled that the procedure will likely need to be repeated for long-term maintenance of continence.<\/p>\n<p><strong>References<\/strong><\/p>\n<ol>\n<li>Chen H, Shipov A, Segev G. Evaluation of cross-linked gelatin as a bulking agent for the management of urinary sphincter mechanism incompetence in female dogs. <em>J Vet Intern Med<\/em>. 2020;34(5):1914-1919. doi:10.1111\/jvim.15857<\/li>\n<li>Burdick S, Berent AC, Weisse C, Langston C. Endoscopic-guided laser ablation of vestibulovaginal septal remnants in dogs: 36 cases (2007\u20132011). <em>JAVMA<\/em>. 2014;244(8):944-949. doi:10.2460\/javma.244.8.944<\/div><\/div><\/li>\n<\/ol>\n<h3 class=\"p3\">Ectopic Ureter<\/h3>\n<p class=\"p1\"><span class=\"s1\">This condition can be unilateral or bilateral and is the primary cause of incontinence in juvenile dogs.<sup>1<\/sup> Affected animals usually drip urine continuously and often get severe urine scald. The abnormal ureteral opening(s) can be repositioned within the bladder through cystoscopic laser ablation or surgical reimplantation.<sup>20-22<\/sup> The latter option should be reserved for dogs with extramural ectopia; cystoscopic laser ablation is the superior option for dogs with intramural (tunnelling) ectopic ureters as complications are rare and the recovery time is brief. Unfortunately, some dogs with ectopic ureter remain incontinent after correction; this is often due to a concurrent short urethra and may improve with phenylpropanolamine.<sup>21,22<\/sup> <\/span><\/p>\n<h3 class=\"p3\">Idiopathic Detrusor Instability<\/h3>\n<p class=\"p1\"><span class=\"s1\">This condition\u2014also known as hyperactive bladder\u2014is characterized by involuntary bladder contractions despite minimal filling; affected dogs exhibit urinary urgency or dribble urine after voiding.<sup>1,3<\/sup> Definitive diagnosis requires cystometry (see under <\/span><strong><span class=\"s2\">IMAGING <\/span><\/strong><span class=\"s1\">below), but it is reasonable to assess the response to drugs<strong> (<\/strong><\/span><strong><span class=\"s2\">TABLE 1<\/span><\/strong><span class=\"s1\"><strong>)<\/strong> such as oxybutynin, an anticholinergic antispasmodic, if the clinical picture is consistent with this diagnosis and conditions such as UTI or urinary tract neoplasia have been reliably excluded.<\/span><\/p>\n<h2 class=\"p2\">Voiding Disorders<\/h2>\n<p class=\"p1\"><span class=\"s1\">Dogs with UI due to a voiding disorder are unable to effectively empty the bladder, and PVRV is &gt;\u20093 mL\/kg.<sup>1<\/sup> This condition is sometimes referred to as overflow incontinence, as urine leaks out when the storage capacity of the bladder is exceeded; this is routinely noted when the dog is resting. These dogs may attempt to urinate but only pass dribbles or short spurts of urine.<sup>23<\/sup> In some cases, a small amount of urine may be forcibly ejected from the bladder when deliberate efforts to void are abandoned. <\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Patients with voiding disorders may again be broadly categorized as having non-neurogenic or neurogenic disorders <strong>(<\/strong><\/span><strong><span class=\"s2\">FIGURE 1<\/span><\/strong><span class=\"s1\"><strong>)<\/strong>.<sup>1<\/sup> Non-neurogenic issues are subcategorized as mechanical or functional; mechanical causes include urolithiasis, urinary tract neoplasia, urethral stricture, prostatic disease, bladder displacement, and extramural compression. Functional disorders include bladder atony or fibrosis and idiopathic functional outflow obstruction. Common neurogenic causes of voiding disorders include those affecting the T3 to L3 and S1 to S3 spinal regions, such as intervertebral disk herniation, ischemic myelopathy, and degenerative lumbosacral stenosis.<sup>24,25<\/sup> Prognosis and treatment will depend on the underlying cause.<\/span><\/p>\n<h3 class=\"p3\">Bladder Displacement<\/h3>\n<p class=\"p1\"><span class=\"s1\">Conditions such as perineal hernia can compromise urine voiding.<sup>26,27<\/sup> Affected dogs are usually intact middle-aged males, and concurrent prostatomegaly may play a role. On digital rectal examination, there is often an obvious weakness within the pelvic canal; in severe cases, a bulge may be visible on either side of the anus. Urethral kinking with caudal displacement of the urinary bladder may occur in dogs of any sexual status and can cause severe compromise to micturition.<sup>28<\/sup> As the affected dog postures to urinate, the bladder moves caudally, and the urethra becomes compressed and occluded. Signs can be intermittent but tend to be more pronounced when the bladder is fully distended. This condition may be diagnosed using contrast cystourethrography and is addressed by surgically securing the cranial aspect of the bladder to the ventrolateral abdominal wall.<\/span><\/p>\n<h3 class=\"p3\">Idiopathic Functional Outflow Obstruction<\/h3>\n<p class=\"p1\"><span class=\"s1\">This condition was traditionally referred to as detrusor\u2013urethral dyssynergia or reflex dyssynergia and is due to failure of the bladder to contract and\/or failure of the urethra to relax.<sup>1<\/sup> Affected patients are usually large-breed, middle-aged males, and clinical signs range from a narrowed and erratic urine stream to complete inability to void.<sup>29-31<\/sup> Signs can wax and wane, and treatment may be delayed if owners fail to grasp the significance of changing urinary patterns. These dogs are particularly prone to secondary bladder atony, as long periods of incomplete emptying slowly stretch the wall and damage the connections between the detrusor fibers.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Treatments focus initially on urethral relaxation<strong> (<\/strong><\/span><strong><span class=\"s2\">TABLE 1<\/span><\/strong><span class=\"s1\"><strong>)<\/strong>, with \u03b1-adrenergic blockers such as prazosin, tamsulosin, or phenoxybenzamine. Skeletal muscle relaxants such as dantrolene sodium, acepromazine, or a benzodiazepine may also be useful, particularly in males, as these agents reduce tone in the extensive urethralis muscle.<sup>1<\/sup> Concurrent detrusor atony may be subsequently addressed with bethanechol; if indicated, <\/span><span class=\"s1\">the authors introduce this drug 2 to 3 days after starting urethral relaxants.<\/span><\/p>\n<h2>Patient Evaluation<\/h2>\n<p class=\"p2\"><span class=\"s1\">The first step in the evaluation of a patient with UI is to collect a detailed history, including duration of clinical signs, pattern(s) of incontinence, voiding behaviors, and response(s) to previous therapy. Patient signalment should be considered; UI in puppies is usually due to anatomic defects such as ectopic ureter, whereas UI in older dogs is more likely to be USMI or related to mechanical or functional obstruction.<\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">On physical examination, careful attention should be paid to the appearance of the external genitalia and surrounding skin. Are the tissues inflamed or urine scalded? A digital rectal examination should be performed in all dogs, as abnormalities of the urethra or prostate may be noted. In older intact males, the structural integrity of the pelvic diaphragm should be carefully assessed. Urinary bladder size and tone should be noted, along with any signs of discomfort. A full neurologic examination should also be performed, including assessment of anal tone. <\/span>It is also very helpful to observe the dog\u2019s behavior during micturition, including ability to effectively posture, and the strength of the urine stream. If necessary, the dog may need to be placed off-leash in a secured area to facilitate voiding. The PVRV should then be established to narrow the list of possible causes of UI.<\/p>\n<h3 class=\"p1\">Diagnostic Testing<\/h3>\n<p class=\"p2\"><span class=\"s1\">Findings on routine urinalysis should be carefully evaluated. Pyuria and bacteriuria indicate UTI; this is most likely to be secondary to UI rather than the cause, although cystitis can exacerbate leakage or trigger urge incontinence in dogs with mild USMI. A quantified urine culture should be performed if UTI is suspected and results used to guide therapy. Abnormal transitional epithelial cells or evidence of squamous metaplasia suggest obstructive conditions and indicate the need for imaging to evaluate urinary tract and prostatic anatomy. Poorly concentrated urine is not a reason for UI per se but will certainly affect the magnitude and frequency of leakage. <\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Results of a CBC and serum biochemical profile should be evaluated. Although these tests are unlikely to provide direct insight into the cause of UI, concurrent issues such as chronic kidney disease or endocrinopathy may exacerbate UI by driving polyuria and should be addressed as appropriate.<\/span><\/p>\n<h3 class=\"p1\">Imaging<\/h3>\n<p class=\"p2\"><span class=\"s1\"><strong>Plain abdominal radiography<\/strong> can provide insight into the size and position of the kidneys, urinary bladder, and prostate<strong> (<\/strong><\/span><strong><span class=\"s2\">FIGURE 2A<\/span><\/strong><span class=\"s1\"><strong>)<\/strong> and can reliably identify radiopaque uroliths. Readily apparent stones are usually calcium oxalate or magnesium ammonium phosphate (struvite); urate stones may sometimes be noted with high-quality imaging.<sup>32,33<\/sup> In males, the perineal and penile urethra are best evaluated with the back legs pulled cranially <strong>(<span class=\"s2\">FIGURE<\/span><\/strong><\/span><strong><span class=\"s2\">\u00a02B<\/span><\/strong><span class=\"s1\"><strong>)<\/strong>. Compressing the bladder with a paddle may facilitate the detection of small cystoliths <strong>(<span class=\"s2\">FIGURE<\/span><\/strong><\/span><strong><span class=\"s2\">\u00a02C AND 2D<\/span><\/strong><span class=\"s1\"><strong>)<\/strong>.<\/span><\/p>\n<div class=\"su-image-carousel  su-image-carousel-has-spacing su-image-carousel-crop su-image-carousel-crop-1-1 su-image-carousel-has-lightbox su-image-carousel-has-outline su-image-carousel-adaptive su-image-carousel-slides-style-default su-image-carousel-controls-style-dark su-image-carousel-align-center\" style=\"max-width:70%\" data-flickity-options='{\"groupCells\":true,\"cellSelector\":\".su-image-carousel-item\",\"adaptiveHeight\":false,\"cellAlign\":\"left\",\"prevNextButtons\":true,\"pageDots\":false,\"autoPlay\":5000,\"imagesLoaded\":true,\"contain\":true,\"selectedAttraction\":0.025,\"friction\":0.28}' id=\"su_image_carousel_69d695f9b2752\"><div class=\"su-image-carousel-item\"><div class=\"su-image-carousel-item-content\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig2A.jpg\" target=\"_blank\" rel=\"noopener noreferrer\" data-caption=\"Figure 2. Right lateral abdominal radiographs of a 5-year-old bichon frise with a history of intermittent urinary incontinence (UI) attributable to a storage issue and characterized by small puddles voided while at rest. (A) Standard lateral abdominal image; the bladder (blue arrowheads) is small and is overlain by the colon (white arrowheads).\"><img loading=\"lazy\" decoding=\"async\" width=\"768\" height=\"519\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig2A-768x519.jpg\" class=\"\" alt=\"\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig2A-768x519.jpg 768w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig2A-300x203.jpg 300w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig2A.jpg 927w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/><span>Figure 2. Right lateral abdominal radiographs of a 5-year-old bichon frise with a history of intermittent urinary incontinence (UI) attributable to a storage issue and characterized by small puddles voided while at rest. (A) Standard lateral abdominal image; the bladder (blue arrowheads) is small and is overlain by the colon (white arrowheads).<\/span><\/a><\/div><\/div><div class=\"su-image-carousel-item\"><div class=\"su-image-carousel-item-content\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig2B.png\" target=\"_blank\" rel=\"noopener noreferrer\" data-caption=\"Figure 2B. The patient\u2019s hind legs have been pulled forward to allow for effective imaging of the prostatic, pelvic, and penile urethra.\"><img loading=\"lazy\" decoding=\"async\" width=\"768\" height=\"526\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig2B-768x526.png\" class=\"\" alt=\"\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig2B-768x526.png 768w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig2B-300x205.png 300w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig2B.png 928w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/><span>Figure 2B. The patient\u2019s hind legs have been pulled forward to allow for effective imaging of the prostatic, pelvic, and penile urethra.<\/span><\/a><\/div><\/div><div class=\"su-image-carousel-item\"><div class=\"su-image-carousel-item-content\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig2C.png\" target=\"_blank\" rel=\"noopener noreferrer\" data-caption=\"Figure 2C. A large plastic spoon is used to compress the urinary bladder and displace the overlying colon dorsally.\"><img loading=\"lazy\" decoding=\"async\" width=\"768\" height=\"519\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig2C-768x519.png\" class=\"\" alt=\"\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig2C-768x519.png 768w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig2C-300x203.png 300w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig2C.png 933w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/><span>Figure 2C. A large plastic spoon is used to compress the urinary bladder and displace the overlying colon dorsally.<\/span><\/a><\/div><\/div><div class=\"su-image-carousel-item\"><div class=\"su-image-carousel-item-content\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig2D.png\" target=\"_blank\" rel=\"noopener noreferrer\" data-caption=\"Figure 2D. Magnified view of the same image as C; more than a dozen tiny cystoliths are now visible (box). These stones were successfully removed with voiding urohydropropulsion and were found to be calcium oxalate. The dog\u2019s diet was adjusted to reduce the risk of stone recurrence, and UI was successfully managed with phenylpropanolamine.\"><img loading=\"lazy\" decoding=\"async\" width=\"768\" height=\"520\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig2D-768x520.png\" class=\"\" alt=\"\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig2D-768x520.png 768w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig2D-300x203.png 300w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig2D.png 934w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/><span>Figure 2D. Magnified view of the same image as C; more than a dozen tiny cystoliths are now visible (box). These stones were successfully removed with voiding urohydropropulsion and were found to be calcium oxalate. The dog\u2019s diet was adjusted to reduce the risk of stone recurrence, and UI was successfully managed with phenylpropanolamine.<\/span><\/a><\/div><\/div><\/div><script id=\"su_image_carousel_69d695f9b2752_script\">if(window.SUImageCarousel){setTimeout(function() {window.SUImageCarousel.initGallery(document.getElementById(\"su_image_carousel_69d695f9b2752\"))}, 0);}var su_image_carousel_69d695f9b2752_script=document.getElementById(\"su_image_carousel_69d695f9b2752_script\");if(su_image_carousel_69d695f9b2752_script){su_image_carousel_69d695f9b2752_script.parentNode.removeChild(su_image_carousel_69d695f9b2752_script);}<\/script>\n<p class=\"p2\"><span class=\"s1\"><strong>Transabdominal ultrasonography<\/strong> allows for detailed evaluation of the kidneys, ureters, urinary bladder, proximal urethra, and prostate, as well as routine identification of masses, cysts, stones, and extraluminal compressive lesions. Although ureteral jets may be visualized using color Doppler ultrasonography, this imaging modality may not reliably identify an ectopic ureter and most experts prefer to rely on cystoscopy to establish or refute this diagnosis.<sup>1,34<\/sup><\/span><\/p>\n<p class=\"p2\"><span class=\"s1\"><strong>Contrast radiographic studies<\/strong> can be performed using standard radiography, fluoroscopy, or computed tomography. As a general rule, patients should be deeply sedated or fully anesthetized for these studies to ensure adequate image collection and minimize risk to personnel. The most appropriate modality will depend on the likely causes of UI in a particular patient. Retrograde positive-contrast cystourethrography is <\/span><span class=\"s1\">often the best choice for patients with signs suggestive of mechanical urethral obstruction; fluoroscopic contrast studies are particularly useful in dogs with fistulae or those with dynamic mechanical obstructions due to caudal displacement of the bladder.<sup>1,28<\/sup> Computed tomography with intravenous contrast administration allows more detailed evaluation of the anatomy without the hindrance of anatomic superimposition. This modality has superior diagnostic reliability for dogs with ectopic ureter than ultrasonography or traditional retrograde contrast studies but is still less sensitive than cystoscopy.<sup>35<\/sup><\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><strong>Cystourethroscopy<\/strong>, direct endoscopic visualization of the urethra and bladder, is highly informative in many instances, and is the most reliable way to identify or exclude urolithiasis, stricture, neoplasia, and ureteral ectopia <strong>(<\/strong><\/span><strong><span class=\"s2\">FIGURE 3<\/span><\/strong><span class=\"s1\"><strong>)<\/strong>. General anesthesia is required for cystourethroscopy, and practitioners must be adequately trained. Rigid cystoscopy is routinely performed in females, whereas a flexible scope is required for males. Patient size must be considered, as the urethra must comfortably accommodate the scope. In males, it is prudent to pass an appropriately sized red-rubber catheter before scheduling cystourethroscopy to be sure that the scope will be able to traverse the distal urethra. If necessary, a minimally invasive perineal approach may be used in males to allow access to the pelvic and prostatic urethra with a rigid scope.<sup>36<\/sup><\/span><\/p>\n<div class=\"su-image-carousel  su-image-carousel-has-spacing su-image-carousel-crop su-image-carousel-crop-1-1 su-image-carousel-has-lightbox su-image-carousel-has-outline su-image-carousel-adaptive su-image-carousel-slides-style-default su-image-carousel-controls-style-dark su-image-carousel-align-center\" style=\"max-width:70%\" data-flickity-options='{\"groupCells\":true,\"cellSelector\":\".su-image-carousel-item\",\"adaptiveHeight\":false,\"cellAlign\":\"left\",\"prevNextButtons\":true,\"pageDots\":false,\"autoPlay\":5000,\"imagesLoaded\":true,\"contain\":true,\"selectedAttraction\":0.025,\"friction\":0.28}' id=\"su_image_carousel_69d695f9b2e08\"><div class=\"su-image-carousel-item\"><div class=\"su-image-carousel-item-content\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig3A.png\" target=\"_blank\" rel=\"noopener noreferrer\" data-caption=\"Figure 3. Cystoscopic images of a 6-month-old female intact goldendoodle with severe urinary incontinence, characterized by persistent dripping. The dog is in dorsal recumbency for the procedure. (A) The opening to an ectopic right ureter (arrowhead) is visible within the urethral lumen (asterisk).\"><img loading=\"lazy\" decoding=\"async\" width=\"615\" height=\"603\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig3A.png\" class=\"\" alt=\"\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig3A.png 615w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig3A-300x294.png 300w\" sizes=\"(max-width: 615px) 100vw, 615px\" \/><span>Figure 3. Cystoscopic images of a 6-month-old female intact goldendoodle with severe urinary incontinence, characterized by persistent dripping. The dog is in dorsal recumbency for the procedure. (A) The opening to an ectopic right ureter (arrowhead) is visible within the urethral lumen (asterisk).<\/span><\/a><\/div><\/div><div class=\"su-image-carousel-item\"><div class=\"su-image-carousel-item-content\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig3B.png\" target=\"_blank\" rel=\"noopener noreferrer\" data-caption=\"Figure 3B. A 5-Fr, yellow, open-ended ureteral catheter has been placed over a hydrophilic guidewire into the ectopic ureter. A diode laser fiber (arrowheads) is being used to cut the tissue between the ectopic ureter and the urethral lumen.\"><img loading=\"lazy\" decoding=\"async\" width=\"607\" height=\"605\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig3B.png\" class=\"\" alt=\"\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig3B.png 607w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig3B-300x300.png 300w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig3B-150x150.png 150w\" sizes=\"(max-width: 607px) 100vw, 607px\" \/><span>Figure 3B. A 5-Fr, yellow, open-ended ureteral catheter has been placed over a hydrophilic guidewire into the ectopic ureter. A diode laser fiber (arrowheads) is being used to cut the tissue between the ectopic ureter and the urethral lumen.<\/span><\/a><\/div><\/div><div class=\"su-image-carousel-item\"><div class=\"su-image-carousel-item-content\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig3C.png\" target=\"_blank\" rel=\"noopener noreferrer\" data-caption=\"Figure 3C. The opening to the right ureter is now within the urinary bladder. The cut edges of the ureter are visible (arrowheads). Urine from the right kidney will now enter the urinary bladder. This dog was completely continent following this procedure.\"><img loading=\"lazy\" decoding=\"async\" width=\"614\" height=\"605\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig3C.png\" class=\"\" alt=\"\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig3C.png 614w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2025\/08\/CookAtiee_UrinaryIncontinence_TVPSepOct25_Fig3C-300x296.png 300w\" sizes=\"(max-width: 614px) 100vw, 614px\" \/><span>Figure 3C. The opening to the right ureter is now within the urinary bladder. The cut edges of the ureter are visible (arrowheads). Urine from the right kidney will now enter the urinary bladder. This dog was completely continent following this procedure.<\/span><\/a><\/div><\/div><\/div><script id=\"su_image_carousel_69d695f9b2e08_script\">if(window.SUImageCarousel){setTimeout(function() {window.SUImageCarousel.initGallery(document.getElementById(\"su_image_carousel_69d695f9b2e08\"))}, 0);}var su_image_carousel_69d695f9b2e08_script=document.getElementById(\"su_image_carousel_69d695f9b2e08_script\");if(su_image_carousel_69d695f9b2e08_script){su_image_carousel_69d695f9b2e08_script.parentNode.removeChild(su_image_carousel_69d695f9b2e08_script);}<\/script>\n<p class=\"p1\"><span class=\"s1\"><strong>Urodynamic studies<\/strong> such as cystometry and urethral pressure profiling are available at some referral centers and can provide specific information regarding lower urinary tract function.<sup>1,37<\/sup> However, specialized equipment and standardized sedation\/anesthesia protocols are necessary, and most clinicians feel that the benefits of performing these studies are limited. Cystometry determines the amount of fluid required to trigger involuntary detrusor contraction and is needed to confirm a diagnosis of detrusor instability or bladder fibrosis.<sup>1<\/sup> Urethral pressure profiling assesses the tone of the urethra and can confirm USMI.<sup>1<\/sup> <\/span><\/p>\n<h2 class=\"p2\">Summary<\/h2>\n<p class=\"p1\"><span class=\"s1\">It is essential to establish a diagnosis in a dog with UI so that appropriate tests and treatments are provided in a timely manner. Initial differentials are influenced by signalment, history, and urine characteristics and should be combined with determination of PVRV. Referral should be recommended for challenging or refractory cases. <\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Differentiating storage disorders from voiding disorders relies on determination of the postvoid residual volume.<\/p>\n","protected":false},"author":693,"featured_media":36144,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"iawp_total_views":7919,"footnotes":""},"categories":[558],"tags":[100,13],"class_list":["post-36090","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-september-october-2025","tag-continuing-education","tag-peer-reviewed","column-continuing-education","column-features","clinical_topics-urology-renal-medicine"],"acf":{"hide_sidebar":false,"hide_sidebar_ad":false,"hide_all_ads":false},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.7 (Yoast SEO v27.3) - 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