{"id":35262,"date":"2024-07-04T18:41:37","date_gmt":"2024-07-04T18:41:37","guid":{"rendered":"https:\/\/todaysveterinarypractice.com\/?p=35262"},"modified":"2025-01-15T19:37:54","modified_gmt":"2025-01-15T19:37:54","slug":"canine-pancreatitis-diagnostics-which-cpl-test-is-best","status":"publish","type":"post","link":"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/gastroenterology\/canine-pancreatitis-diagnostics-which-cpl-test-is-best\/","title":{"rendered":"Canine Pancreatitis Diagnostics: Which cPL Test Is Best?"},"content":{"rendered":"<p><b>Editor\u2019s Note: <\/b>This is an excerpt from Research Wrapped, a free monthly newsletter that collects the latest scientific research relevant to small animal veterinarians and pulls out practical takeaways. To be the first to receive this newsletter each month, <a href=\"https:\/\/go.navc.com\/40wZQps\" target=\"_blank\" rel=\"noopener\">subscribe here<\/a>.<\/p>\n<hr \/>\n<p><a href=\"https:\/\/todaysveterinarypractice.com\/hepatology\/diagnosing-acute-pancreatitis-in-dogs\/\"><span style=\"font-weight: 400\">Diagnosing<\/span><\/a><span style=\"font-weight: 400\"> and <\/span><a href=\"https:\/\/todaysveterinarypractice.com\/pharmacology\/treatment-options-for-canine-pancreatitis\/\"><span style=\"font-weight: 400\">treating<\/span><\/a><span style=\"font-weight: 400\"> a dog with pancreatitis can be a real clinical challenge. A pancreatic biopsy is the gold standard for diagnosis, but we know the issues and concerns with a pancreatic tissue sampling procedure. So, we rely on less-invasive diagnostic tests such as complete blood cell count, serum biochemistry profile, and abdominal ultrasonography. Yet, these tests <\/span><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsap.12274\"><span style=\"font-weight: 400\">show low specificity<\/span><\/a><span style=\"font-weight: 400\"> in the diagnosis of pancreatitis. Serum canine pancreatic lipase (cPL), a lipase that originates in the pancreas and increases in the event of pancreatic acinar cell damage, is <\/span><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvim.15039\"><span style=\"font-weight: 400\">far more specific and sensitive<\/span><\/a><span style=\"font-weight: 400\">, and consequently an incredibly helpful biomarker for the diagnosis of canine pancreatitis.<\/span><\/p>\n<p><span style=\"font-weight: 400\">Our featured study compares Vcheck cPL (Bionote), a more recently released assay, with 2 other commercially available serum cPL measurement assays: SNAP cPL (IDEXX) and Spec cPL (IDEXX).<\/span><\/p>\n<p><span style=\"font-weight: 400\">Of the 50 cPL assays evaluated, most (94%) were in agreement; therefore, the 3 cPL assays show a significantly high correlation. The contention with SNAP cPL is the potential for reading error as color intensity indicates a qualitative \u201cnormal\u201d or \u201cabnormal.\u201d The Spec cPL provides quantified data yet requires a large blood sample and for the sample to be sent to an external laboratory, taking several days for results to return. With the recent development of Vcheck cPL, a quantified concentration of cPL is displayed within 5 minutes of loading in a small serum sample.<\/span><\/p>\n<hr \/>\n<p><b>Editor\u2019s Note:<\/b>This article is an excerpt from the Research Wrapped monthly\u00a0newsletter. <a href=\"https:\/\/go.navc.com\/40wZQps\" target=\"_blank\" rel=\"noopener\">Subscribe here for free<\/a>.<\/p>\n<hr \/>\n<p><span style=\"font-weight: 400\">\u00a0<\/span><span style=\"font-weight: 400\">In this study, Spec cPL and Vcheck cPL showed similar increasing or decreasing results in serum cPL concentration during treatment. With their quantified data, those 2 tests are helpful diagnostic tools to monitor a patient over the course of treatment. The costliness of replacing existing laboratory equipment with an alternative assay method, Spec cPL or Vcheck cPL, may be justified by this additional capability of monitoring beyond the diagnosis of pancreatitis. <\/span><span style=\"font-weight: 400\">It should also be noted that IDEXX recently announced\u2014after the publication of this study\u2014that it plans to release the <\/span><a href=\"https:\/\/www.idexx.com\/en\/about-idexx\/news\/idexx-expands-test-menu-catalyst-platform-pancreatitis\/\"><span style=\"font-weight: 400\">Catalyst Pancreatic Lipase Test in September 2024<\/span><\/a><span style=\"font-weight: 400\">. IDEXX says this new test will provide quantifiable results to diagnose pancreatitis in less than 10 minutes in-house, either as an add-on to a chemistry test or as a stand-alone test.<\/span><\/p>\n<p><span style=\"font-weight: 400\">Unlike patients with acute pancreatitis, patients with chronic pancreatitis often show no clinical signs or elevation of serum cPL. Because of pancreatic fibrosis and atrophy, pancreatic lipase may not leak from the pancreas of those patients. Consequently, false negative tests are commonly observed in patients with chronic pancreatitis. Thus, the sensitivity of cPL assays in diagnosing chronic pancreatitis is lower than in acute pancreatitis. Additionally, despite mild or no clinical signs, serum cPL concentrations may increase in dogs with chronic pancreatitis. A treatment plan based solely on cPL measurement is not appropriate for the management of those cases; a long-term outpatient treatment plan based on history, clinical signs, CRP concentration, and abdominal ultrasonography may be necessary.<\/span><\/p>\n<h3>The Study:<\/h3>\n<p><b>A comparative analysis of canine pancreatic lipase tests for diagnosing pancreatitis in dogs.\u00a0<\/b><\/p>\n<p><span style=\"font-weight: 400\">Kim JK, Hwang SY, Kim SE, et al. <\/span><i><span style=\"font-weight: 400\">J Vet Sci<\/span><\/i><span style=\"font-weight: 400\">. <a href=\"https:\/\/doi.org\/10.4142\/jvs.24001\" target=\"_blank\" rel=\"noopener\">doi.org\/10.4142\/jvs.24001<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>This featured study compares Vcheck cPL, a more recently released assay, with 2 other commercially available serum cPL measurement assays: SNAP cPL and Spec cPL.<\/p>\n","protected":false},"author":236,"featured_media":35271,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"iawp_total_views":2426,"footnotes":""},"categories":[342],"tags":[],"class_list":["post-35262","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-digital-exclusive","column-research-wrapped","clinical_topics-gastroenterology"],"acf":{"hide_sidebar":false,"hide_sidebar_ad":false,"hide_all_ads":false},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.7 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Canine Pancreatitis Diagnostics: Which cPL Test Is Best? | Today&#039;s Veterinary Practice<\/title>\n<meta name=\"description\" content=\"This featured study compares Vcheck cPL with 2 other commercially available serum cPL measurement assays: SNAP cPL and Spec cPL.\" \/>\n<meta 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