{"id":32523,"date":"2023-04-13T18:15:06","date_gmt":"2023-04-13T18:15:06","guid":{"rendered":"https:\/\/todaysveterinarypractice.com\/?p=32523"},"modified":"2023-04-21T19:57:32","modified_gmt":"2023-04-21T19:57:32","slug":"case-series-necrotizing-fasciitis-in-4-dogs","status":"publish","type":"post","link":"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/emergency-medicine-critical-care\/necrotizing-fasciitis-in-dogs\/","title":{"rendered":"Case Series: Necrotizing Fasciitis in 4 Dogs"},"content":{"rendered":"<p><div class=\"su-note\"  style=\"border-color:#d8d8d8;border-radius:3px;-moz-border-radius:3px;-webkit-border-radius:3px;\"><div class=\"su-note-inner su-u-clearfix su-u-trim\" style=\"background-color:#f2f2f2;border-color:#ffffff;color:#333333;border-radius:3px;-moz-border-radius:3px;-webkit-border-radius:3px;\"><strong>Abstract<\/strong><\/p>\n<p class=\"p1\">Necrotizing fasciitis (NF) is a life-threatening, rapidly spreading bacterial infection of the soft tissues, characterized by necrosis of the fascial planes and surrounding structures. This case series describes the presentation, diagnostic findings, treatments, and outcomes for 4 dogs for which a diagnosis of NF was strongly suspected.<\/p>\n<p class=\"p1\">Definitive diagnosis is difficult to achieve before surgical intervention is needed. Delays in recognition will lead to an advanced state of clinical disease, resulting in poor outcomes. Despite aggressive medical management, including intravenous antibiotics, the mortality rate for dogs with NF is 100% in the absence of surgical intervention.<\/p>\n<p><strong>Take-Home Points<\/strong><\/p>\n<ul>\n<li class=\"p1\">Clinical suspicion for necrotizing fasciitis (NF) should be raised by mounting pain, swelling\/edema, and cutaneous bruising in combination with signs of septic shock.<\/li>\n<li class=\"p1\">Although not pathognomonic for NF, soft wisps within the subcutaneous space seen on radiographs or subcutaneous edema with thickened fascial planes noted during ultrasonography in a systemically ill patient should make NF a differential diagnosis.<\/li>\n<li class=\"p1\">Clinicians with a high degree of suspicion for NF should recommend immediate surgical intervention after the dog is hemodynamically stable.<\/li>\n<li class=\"p1\">The preferred antibiotics for NF are \u00df-lactam and \u00df-lactamase inhibitors, including high-dose penicillins, carbapenems, and clindamycin. Fluoroquinolones are not recommended.<\/li>\n<li class=\"p1\">The mortality rate for NF with medical management alone is 100%; surgical intervention is required for improved outcomes.<\/div><\/div><\/li>\n<\/ul>\n<p class=\"p1\"><span class=\"s1\">Necrotizing fasciitis (NF) is a rapidly progressive, life-threatening bacterial infection of the subcutaneous tissues, fascia, and occasionally skeletal muscle. The most common causative bacterium is <\/span><span class=\"s2\">\u03b2<\/span><span class=\"s1\">-hemolytic <i>Streptococcus canis<\/i>, a group G <i>Streptococcus <\/i>species. Other reported causes include <i>Staphylococcus pseudintermedius<\/i>, <i>Staphylococcus aureus<\/i>, <i>Pasteurella multocida<\/i>, <i>Pseudomonas aeruginosa<\/i>, <i>Escherichia coli<\/i>, and <i>Serratia marcescens<\/i>.<sup>1-4<\/sup> Predisposing factors, although not always evident, are minor trauma, blunt force trauma, and immunocompromised states.<sup>1-5<\/sup><\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">In dogs, the most common signs of NF are rapidly progressive swelling, lameness, and hemorrhagic skin pigmentation (often progressing from red to purple to black). Most common is cutaneous involvement of the limbs and neck; however, the trunk can also be involved <strong>(<\/strong><\/span><strong><span class=\"s3\">FIGURE 1<\/span><\/strong><span class=\"s1\"><strong>)<\/strong>.<sup>4,6-8<\/sup> During the early stages of NF, dogs often exhibit extreme pain that is disproportionate to the outward appearance of their lesion and then rapidly progress to having septic shock.<sup>6<\/sup> Multiple organ dysfunction <\/span>syndrome, disseminated intravascular coagulation<span class=\"s1\"> (DIC), and shock leads to death in 70% to 80% of dogs with NF.<sup>9<\/sup> Prompt and aggressive surgical intervention, including debridement, necrosectomy, and fasciotomy, is paramount to patient survival.<sup>1-3,5,10,11<\/sup> Prompt diagnosis of NF and timely surgical intervention are often impeded by lack of pathognomonic physical examination findings and the time needed to receive biopsy and culture results.<\/span><\/p>\n<div id=\"attachment_32526\" style=\"width: 460px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2023\/04\/SchaerFraser_TVPMayJune23_NecrotizingFasciitis_Figure1A.png\"><img fetchpriority=\"high\" decoding=\"async\" aria-describedby=\"caption-attachment-32526\" class=\" wp-image-32526\" src=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2023\/04\/SchaerFraser_TVPMayJune23_NecrotizingFasciitis_Figure1A.png\" alt=\"\" width=\"450\" height=\"336\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2023\/04\/SchaerFraser_TVPMayJune23_NecrotizingFasciitis_Figure1A.png 864w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2023\/04\/SchaerFraser_TVPMayJune23_NecrotizingFasciitis_Figure1A-300x224.png 300w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2023\/04\/SchaerFraser_TVPMayJune23_NecrotizingFasciitis_Figure1A-768x573.png 768w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/><\/a><p id=\"caption-attachment-32526\" class=\"wp-caption-text\">Figure1A<\/p><\/div>\n<div id=\"attachment_32527\" style=\"width: 461px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2023\/04\/SchaerFraser_TVPMayJune23_NecrotizingFasciitis_Figure1B.png\"><img decoding=\"async\" aria-describedby=\"caption-attachment-32527\" class=\" wp-image-32527\" src=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2023\/04\/SchaerFraser_TVPMayJune23_NecrotizingFasciitis_Figure1B.png\" alt=\"\" width=\"451\" height=\"338\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2023\/04\/SchaerFraser_TVPMayJune23_NecrotizingFasciitis_Figure1B.png 864w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2023\/04\/SchaerFraser_TVPMayJune23_NecrotizingFasciitis_Figure1B-300x225.png 300w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2023\/04\/SchaerFraser_TVPMayJune23_NecrotizingFasciitis_Figure1B-768x576.png 768w\" sizes=\"(max-width: 451px) 100vw, 451px\" \/><\/a><p id=\"caption-attachment-32527\" class=\"wp-caption-text\">Figure 1B. Dogs with cutaneous lesions noted primarily on the trunk.<\/p><\/div>\n<p class=\"p1\"><span class=\"s1\">This case series describes the presentation and diagnostic and laboratory findings of NF while emphasizing the need for urgent and aggressive surgical and medical interventions.<\/span><\/p>\n<h2 class=\"p3\">History and Presentation<\/h2>\n<p class=\"p1\"><span class=\"s1\">All 4 dogs were referred from primary care or specialty hospitals and had received treatment before arrival at the University of Florida College of Veterinary Medicine (UFCVM). Previous treatment for 3 of the dogs was nonsteroidal anti-inflammatory drugs for 1 to 5 days before presentation, while the other dog had received oral and injectable antibiotics before referral. <\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Patient signalments, presenting complaints, and affected areas are listed in <\/span><strong><span class=\"s3\">TABLE 1<\/span><\/strong><span class=\"s1\">. Of the 4 dogs, 3\u00a0had at least 1 swollen limb, of which 2 had multiple affected limbs. Two dogs had ventral truncal edema.<\/span><\/p>\n<p><a href=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2023\/04\/SchaerFraser_TVPMayJune23_NecrotizingFasciitis_Table1.png\"><img decoding=\"async\" class=\"aligncenter size-full wp-image-32532\" src=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2023\/04\/SchaerFraser_TVPMayJune23_NecrotizingFasciitis_Table1.png\" alt=\"\" width=\"2059\" height=\"1918\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2023\/04\/SchaerFraser_TVPMayJune23_NecrotizingFasciitis_Table1.png 2059w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2023\/04\/SchaerFraser_TVPMayJune23_NecrotizingFasciitis_Table1-300x279.png 300w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2023\/04\/SchaerFraser_TVPMayJune23_NecrotizingFasciitis_Table1-1024x954.png 1024w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2023\/04\/SchaerFraser_TVPMayJune23_NecrotizingFasciitis_Table1-768x715.png 768w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2023\/04\/SchaerFraser_TVPMayJune23_NecrotizingFasciitis_Table1-1536x1431.png 1536w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2023\/04\/SchaerFraser_TVPMayJune23_NecrotizingFasciitis_Table1-2048x1908.png 2048w\" sizes=\"(max-width: 2059px) 100vw, 2059px\" \/><\/a><\/p>\n<p class=\"p1\"><span class=\"s1\">At the time of referral to the UFCVM, 3 dogs were notably dehydrated, were painful, and had altered mentation (1 dull, 2 obtunded). The remaining dog had been hospitalized with supportive care at a specialty hospital for 3 days before presentation. At the time of the referral, that dog was euhydrated and exhibited moderate mental depression and generalized weakness. The body temperatures of all 4 dogs ranged from normal to elevated (38.6 \u00b0C to 40.3 \u00b0C [101.5 \u00b0F to 104.6 \u00b0F]).<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">All 4 dogs were tachycardic and had gross limb and\/or ventral body wall edema, consistent with the owners\u2019 complaints of \u201cswelling.\u201d All 4 had gross bruising of the affected area; the lesions on patient 3 were not identified until the husky\u2019s thick hair coat was shaved during postmortem examination.<\/span><\/p>\n<h2 class=\"p3\">Diagnostic Test Results<\/h2>\n<h3 class=\"p4\">Blood Work<\/h3>\n<p class=\"p1\"><span class=\"s1\">Serum biochemical and hematologic samples were available for all patients. Three dogs had inflammatory leukograms, and all 4 exhibited a left shift. Moderate to severe thrombocytopenia was present in 3 of the dogs at the time of presentation. Plasma fibrinogen concentration was reported for 3 dogs, of which 2 had hyperfibrinogenemia consistent with inflammation. The most common biochemical findings, found for 3\u00a0dogs, were elevated serum alkaline phosphatase, hyperbilirubinemia, and hyponatremia. Blood lactate concentration was moderately elevated in 2 of the dogs, and clotting times were marginally increased in 3. All\u00a04\u00a0dogs were normoglycemic and normotensive at the time of presentation; 1 had received parenteral dextrose supplementation before referral. <\/span><\/p>\n<h3 class=\"p4\">Imaging and Cytology<\/h3>\n<p class=\"p1\"><span class=\"s1\">In addition to clinical findings, imaging is a valuable tool for diagnosis of NF. Patient 1 arrived with radiographs taken by the primary veterinarian, which demonstrated linear soft tissue wisps within the subcutaneous space of the right antebrachium <strong>(<\/strong><\/span><strong><span class=\"s3\">FIGURE\u00a02<\/span><\/strong><span class=\"s1\"><strong>)<\/strong>. Computed tomography later performed at the UFCVM confirmed marked thickening of the subcutaneous tissue and fascial planes by fluid-attenuating material. Blood cultures for patient 1 were positive for <i>S canis<\/i> and <i>S pseudintermedius<\/i>, further supporting the clinical diagnosis of NF.<\/span><\/p>\n<div id=\"attachment_32528\" style=\"width: 459px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2023\/04\/SchaerFraser_TVPMayJune23_NecrotizingFasciitis_Figure2.png\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-32528\" class=\" wp-image-32528\" src=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2023\/04\/SchaerFraser_TVPMayJune23_NecrotizingFasciitis_Figure2.png\" alt=\"\" width=\"449\" height=\"334\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2023\/04\/SchaerFraser_TVPMayJune23_NecrotizingFasciitis_Figure2.png 864w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2023\/04\/SchaerFraser_TVPMayJune23_NecrotizingFasciitis_Figure2-300x223.png 300w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2023\/04\/SchaerFraser_TVPMayJune23_NecrotizingFasciitis_Figure2-768x571.png 768w\" sizes=\"(max-width: 449px) 100vw, 449px\" \/><\/a><p id=\"caption-attachment-32528\" class=\"wp-caption-text\">Figure 2. Extremity radiographs from patient 1, illustrating linear soft tissue wisps (arrow) within the subcutaneous space of the right antebrachium and extending up the chest. Courtesy of Dr. Ashton Hudson<\/p><\/div>\n<p class=\"p1\"><span class=\"s1\">Radiographs for patient 2 demonstrated soft tissue swelling along the left lateral thoracic and abdominal body wall, with subcutaneous gas. Although the swelling was abnormal, the gas was initially attributed to recent abdominal surgery. Ultrasonography revealed thickened subcutaneous tissues with moderate dissecting anechoic fluid consistent with the working diagnosis of NF <strong>(<\/strong><\/span><strong><span class=\"s3\">FIGURE\u00a03<\/span><\/strong><span class=\"s1\"><strong>)<\/strong>. <i>E coli<\/i> was cultured from the site of the initial abdominal incision (now enlarged, swollen, edematous, and severely bruised).<\/span><\/p>\n<div id=\"attachment_32529\" style=\"width: 510px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2023\/04\/SchaerFraser_TVPMayJune23_NecrotizingFasciitis_Figure3.png\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-32529\" class=\" wp-image-32529\" src=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2023\/04\/SchaerFraser_TVPMayJune23_NecrotizingFasciitis_Figure3.png\" alt=\"\" width=\"500\" height=\"250\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2023\/04\/SchaerFraser_TVPMayJune23_NecrotizingFasciitis_Figure3.png 1228w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2023\/04\/SchaerFraser_TVPMayJune23_NecrotizingFasciitis_Figure3-300x150.png 300w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2023\/04\/SchaerFraser_TVPMayJune23_NecrotizingFasciitis_Figure3-1024x512.png 1024w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2023\/04\/SchaerFraser_TVPMayJune23_NecrotizingFasciitis_Figure3-768x384.png 768w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><\/a><p id=\"caption-attachment-32529\" class=\"wp-caption-text\">Figure 3. Ultrasonography image from patient 2, illustrating the extensive subcutaneous edema, supporting the clinical suspicion of necrotizing fasciitis.<\/p><\/div>\n<p class=\"p1\"><span class=\"s1\">For patient 3, NF was confirmed at postmortem examination, which revealed necrotizing inflammation within the truncal musculature and fascia, within the subcutaneous tissues along the thorax, and extending up the neck <strong>(<\/strong><\/span><strong><span class=\"s3\">FIGURE 4<\/span><\/strong><span class=\"s1\"><strong>)<\/strong>.<\/span><\/p>\n<div id=\"attachment_32530\" style=\"width: 461px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2023\/04\/SchaerFraser_TVPMayJune23_NecrotizingFasciitis_Figure4.png\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-32530\" class=\" wp-image-32530\" src=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2023\/04\/SchaerFraser_TVPMayJune23_NecrotizingFasciitis_Figure4.png\" alt=\"\" width=\"451\" height=\"320\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2023\/04\/SchaerFraser_TVPMayJune23_NecrotizingFasciitis_Figure4.png 864w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2023\/04\/SchaerFraser_TVPMayJune23_NecrotizingFasciitis_Figure4-300x213.png 300w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2023\/04\/SchaerFraser_TVPMayJune23_NecrotizingFasciitis_Figure4-768x545.png 768w\" sizes=\"(max-width: 451px) 100vw, 451px\" \/><\/a><p id=\"caption-attachment-32530\" class=\"wp-caption-text\">Figure 4. Clinical images of patient 3 with rapid, extensive bruising secondary to necrotizing fasciitis.<\/p><\/div>\n<p class=\"p1\"><span class=\"s1\">Patient 4 underwent limited imaging; however, cytology of the cutaneous lesion revealed degenerate neutrophils with intracellular coccobacilli, emphasizing clinical suspicion for NF when interpreted with history, clinical signs, and disease progression.<\/span><\/p>\n<h2 class=\"p3\">Treatments and Outcomes<\/h2>\n<p class=\"p1\"><span class=\"s1\">One patient was euthanized after initial diagnostic testing, and the other 3 underwent aggressive medical management. All 3 hospitalized dogs initially received IV antibiotics (ampicillin\/sulbactam and ceftazidime). One of these dogs also received clindamycin, while another received a single dose of enrofloxacin. None of these dogs underwent surgical intervention because their advanced stage of disease rapidly progressed during attempts to medically stabilize them. DIC developed in 1 dog, and acute kidney injury developed in another. All 3 hospitalized dogs were euthanized within 2 days; median survival time was 6 days (range 4 to 7 days) from the onset of clinical signs. <\/span><\/p>\n<h2 class=\"p3\">Discussion<\/h2>\n<p class=\"p1\"><span class=\"s1\">For all 4 dogs in this case series, clinical suspicion of NF was high and early surgical intervention was not performed. Despite aggressive supportive care and broad-spectrum antimicrobial therapy, NF progressed rapidly, resulting in a poor outcome for all 4 dogs. Previous studies have reported a mortality rate of 100% for dogs receiving antibiotic therapy in the absence of timely surgical debridement.<sup>1,4,6<\/sup><\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Of the 4 dogs in this case series, 3 had no history of trauma and the fourth had recently undergone surgery. Although surgery provides a break in the skin barrier for the introduction of bacteria, the pathophysiology of NF in the absence of trauma in canids is not reported. We can postulate from the human literature that an unknown factor induces a repair response, resulting in the recruitment of leukocytes, along with activation and multiplication of progenitor cells to the affected site. The activated myogenic progenitor cells and macrophages increase vimentin expression and serve as a ligand for binding transient bacteria trafficked to the site. The bacteria proliferate and release exotoxins. The capillaries become occluded by toxin-induced platelet\u2013leukocyte aggregates and damage the vascular endothelium. That blockade results in fluid leakage, tissue swelling, erythema, and ischemia of deep soft tissues. As arteries become occluded, the deep tissue necrosis spreads to the upper tissue layers, exhibited as the cutaneous changes described.<sup>12,13<\/sup> <\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">The preferred antibiotics are <\/span><span class=\"s2\">\u03b2<\/span><span class=\"s1\">-lactam and <\/span><span class=\"s2\">\u03b2<\/span><span class=\"s1\">-lactamase inhibitors; most frequently used are penicillins, carbapenems, and clindamycin.<sup>14<\/sup> Fluoroquinolones are not recommended due to their limited activity against <i>Streptococcus<\/i> species and the potential for increasing pathogenicity.<sup>15<\/sup> Supportive care is aimed at treating the patient\u2019s systemic status with IV fluid therapy and pain control while closely monitoring vital parameters. Patients that lapse into a hypotensive crisis despite adequate fluid resuscitation may require vasopressors. <\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">The most recent and extensive veterinary study suggests a survivability rate of 80% to 90% for dogs that receive a combination of surgery, antibiotic therapy, and supportive care.<sup>1 <\/sup>The stark contrast in mortality rate with and without surgical intervention is compelling evidence for immediate surgical intervention. Various surgical procedures, including debridement, drain placement, and negative pressure wound therapy, have been described with successful outcomes.<sup>1-3,5,10,11,16<\/sup> In humans, mortality increased by 9.4-fold when surgery was delayed for more than 24 hours.<sup>17<\/sup> Delay between presentation and surgical intervention is extended by awaiting biopsy results, cytology results, or cultures before performing surgery. Postoperative hyperbaric oxygen treatment might be of benefit.<sup>14<\/sup><b> <\/b><\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Clinicians should recommend immediate surgery based on a high clinical index of suspicion after the patient is hemodynamically stabilized. Clinical suspicion should be raised by pain disproportionate to physical examination findings, swelling\/edema, and rapidly advancing diffuse skin bruising with accompanying signs of systemic illness (most commonly fever and tachycardia). To track progression throughout hospitalization, the bruising may be outlined with a permanent marker at the time of admission. Another preoperative examination feature is a positive \u201cfinger test.\u201d This test is suggestive of NF when a gloved finger is inserted into the affected site and a lack of bleeding and resistance to blunt dissection is observed, often accompanied by a \u201cmurky dishwater fluid.\u201d<sup>18<\/sup><b> <\/b><\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Although the current veterinary literature suggests that most NF lesions are on the extremities or neck, in this case series, all 4 dogs had lesions on their trunk.<sup>1,8<\/sup> Three dogs had moderate to severe thrombocytopenia at presentation, most likely resulting from an ongoing consumptive coagulopathy, which further justifies assessing hemostasis during the initial diagnostic and treatment stages of NF, especially because major surgery is anticipated.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">The radiographic feature of soft linear wisps in the subcutaneous space should raise concern for NF. Documented in a previous case report, this diagnostic finding is particularly valuable for primary care clinicians who do not have access to other imaging modalities.<sup>2<\/sup> Although the linear wisps are not pathognomonic for NF, this finding in the absence of trauma in a patient with evidence of systemic illness should place NF as a differential diagnosis.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">The UFCVM operates as a tertiary referral facility, and all 4 dogs in this case series were evaluated and treated at other facilities before arrival. The average duration of clinical signs before presentation was 4.5 days (range 2 to 6 days), which usually leads to a catastrophic ending.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Limitations of this case series included it being retrospective and having a limited number of cases. Future prospective studies with standardized diagnostic, therapeutic, and surgical protocols should aid in developing a scoring system to rapidly identify NF and improve the time between presentation and surgical intervention.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Although we cannot predict favorable outcomes for all dogs with early surgical intervention, we can surmise that delayed surgical intervention significantly contributed to the high mortality rate reported in this case series. Because surgical treatment can be cost-prohibitive for many clients, euthanasia is a suitable option for patients with this highly morbid condition.<\/span><\/p>\n<h2 class=\"p3\">Summary<\/h2>\n<p class=\"p1\"><span class=\"s1\">NF is a ravaging disease that rapidly destroys local tissues, earning its moniker \u201cflesh-eating disease.\u201d It commonly causes extreme pain disproportionate to the external appearance of associated lesions, swelling or edema, and reddish to black pigmentation of the affected area. These findings, combined with signs of systemic shock, should raise significant clinical suspicion for NF requiring urgent surgical exploration. Referral to surgery before the onset of septic shock will likely improve the prognosis, but failure to do so carries a grave prognosis warranting humane euthanasia. <\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Necrotizing fasciitis, or commonly known as the \u201cflesh-eating disease,&#8221; has a 100% mortality rate if surgical intervention is not rapidly instituted.<\/p>\n","protected":false},"author":236,"featured_media":32531,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"iawp_total_views":9340,"footnotes":""},"categories":[421],"tags":[13],"class_list":["post-32523","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-may-june-2023","tag-peer-reviewed","column-case-reports","column-features","clinical_topics-emergency-medicine-critical-care"],"acf":{"hide_sidebar":false,"hide_sidebar_ad":false,"hide_all_ads":false},"yoast_head":"<!-- This site is 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