{"id":31446,"date":"2022-08-09T19:32:20","date_gmt":"2022-08-09T19:32:20","guid":{"rendered":"https:\/\/todaysveterinarypractice.com\/?p=31446"},"modified":"2024-05-01T14:58:11","modified_gmt":"2024-05-01T14:58:11","slug":"anesthesia-and-analgesia-in-brachycephalic-dogs","status":"publish","type":"post","link":"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/anesthesiology\/anesthesia-and-analgesia-in-brachycephalic-dogs\/","title":{"rendered":"Anesthesia and Analgesia in Brachycephalic Dogs"},"content":{"rendered":"<p class=\"p1\"><span class=\"s1\">Brachycephalic dogs (e.g., bulldogs, pugs, Shih Tzus) are extremely popular as pets, and their presentation for procedures that require anesthesia is common. This general review of anesthetic management of brachycephalic dogs focuses on dogs with components of brachycephalic obstructive airway syndrome (BOAS) but does not address specific procedures for airway surgery. Dogs with concurrent comorbidities or age-related physiologic changes may need drugs or dosages other than those discussed in this article. The overall health of the animal must be considered before choosing anesthetic protocols. The fundamental goals of anesthetic management in brachycephalic dogs are listed in <\/span><span class=\"s2\"><b>BOX 1<\/b><\/span><span class=\"s1\">.<\/span><\/p>\n<div class=\"su-box su-box-style-default\" id=\"\" style=\"border-color:#606060;border-radius:3px;\"><div class=\"su-box-title\" style=\"background-color:#939393;color:#FFFFFF;border-top-left-radius:1px;border-top-right-radius:1px\">BOX 1 Goals of Anesthetic Management in Brachycephalic Patients<\/div><div class=\"su-box-content su-u-clearfix su-u-trim\" style=\"border-bottom-left-radius:1px;border-bottom-right-radius:1px\">\n<ul>\n<li>Maintain a stress-free induction and recovery<\/li>\n<li>Support tissue oxygen delivery throughout the entire anesthetic procedure<\/li>\n<li>Secure and maintain a patent airway<\/li>\n<li>Control vomiting\/aspiration to prevent aspiration pneumonia<\/li>\n<li>Provide a pain-free recovery <\/div><\/div><\/li>\n<\/ul>\n<h2 class=\"p2\">Physical Factors Affecting Anesthesia Management in Brachycephalic Dogs<\/h2>\n<p class=\"p1\"><span class=\"s1\">Among other complications, the flattened features of the brachycephalic skull compress upper airway structures, which can cause a variety of medical problems and be particularly concerning for anesthetic safety. The main effect of narrowed airway structures in these animals is increased work of breathing. Any increase in respiratory effort, such as that caused by stress, excitement, pain, or hyperthermia, causes increasingly negative airway pressure and further airway <\/span>narrowing with subsequent hypoventilation, hypoxemia, <span class=\"s1\">hypercarbia, and, potentially, airway collapse. Thus, a major goal of anesthetic management in these patients is avoidance of stressful situations. <\/span><\/p>\n<h3 class=\"p3\">Brachycephalic Obstructive Airway Syndrome (BOAS)<\/h3>\n<p class=\"p1\"><span class=\"s1\">Many brachycephalic patients have components of BOAS. Airway components of BOAS and their impact on anesthesia are listed in <\/span><span class=\"s2\"><b>TABLE 1<\/b><\/span><span class=\"s1\">.<\/span><\/p>\n<p><a href=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Table1.png\"><img fetchpriority=\"high\" decoding=\"async\" class=\"aligncenter size-full wp-image-31352\" src=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Table1.png\" alt=\"\" width=\"2012\" height=\"1147\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Table1.png 2012w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Table1-300x171.png 300w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Table1-1024x584.png 1024w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Table1-768x438.png 768w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Table1-1536x876.png 1536w\" sizes=\"(max-width: 2012px) 100vw, 2012px\" \/><\/a><\/p>\n<p class=\"p1\"><span class=\"s1\">Brachycephalic dogs with BOAS are twice as likely to have anesthesia complications as nonbrachycephalic dogs, with most complications, primarily dyspnea, regurgitation, and aspiration pneumonia, occurring in the postoperative period.<sup>1,2<\/sup> Prevention of aspiration pneumonia is also a main goal of anesthetic management,<sup>2<\/sup> and the author recommends antiemetics for all brachycephalic patients undergoing anesthesia. <\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">In one study, the rate of postoperative complications in brachycephalic dogs undergoing anesthesia for imaging or surgeries other than airway surgeries was 13.9% versus 3.6% in nonbrachycephalic dogs.<sup>1<\/sup> In the same study, brachycephalic dogs were 1.57 times as likely to have intra-anesthetic complications and 4.33 times as likely to have postanesthetic complications. Although complications in recovery after surgery to correct BOAS are common, dogs that had a previous airway surgery to correct components of BOAS had fewer complications in the recovery period of a subsequent anesthetic event.<sup>3<\/sup> Thus, surgical correction of BOAS components should be done at an early age to improve both quality of life and safety of subsequent anesthetic procedures. <\/span><\/p>\n<h3 class=\"p3\">Cardiovascular Concerns<\/h3>\n<p class=\"p1\"><span class=\"s1\">Brachycephalics have higher vagal tone than dogs of other breeds,<sup>4,5<\/sup> and those with BOAS can have an exaggerated vagal response with rapid and potentially profound bradycardia when the upper airway is manipulated, as during surgery, intubation, or extubation. Anticholinergics may be indicated in some patients (see <b>Potential Adjunct Drugs<\/b>).<\/span><\/p>\n<h3 class=\"p3\">Gastrointestinal Disease<\/h3>\n<p class=\"p1\"><span class=\"s1\">Esophageal and gastrointestinal (GI) tract lesions, including esophagitis, gastroesophageal reflux, gastritis, and hiatal hernia, are prevalent in brachycephalic dogs with upper respiratory dysfunction. A history of signs of GI abnormalities is highly linked to risk of aspiration pneumonia.<sup>6-10<\/sup> Stabilization or treatment of GI disease prior to anesthesia is recommended. However, correction of upper airway dysfunction is often the key to resolution of GI signs. <\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">The presence of a hiatal hernia is a risk factor for gastroesophageal reflux, as is prolonged fasting.<sup>11<\/sup> Thus, prolonged fasting may not be appropriate for brachycephalic dogs. A fast time of less than 6 hours is recommended in the American Animal Hospital Association guidelines,<sup>12<\/sup> and a small meal 3 hours prior to anesthesia may be beneficial to decrease reflux.<sup>11<\/sup> However, ideal fasting times are still unknown and \u201cstandard\u201d fasting times (i.e., no food after midnight the day before surgery) may still be appropriate. <\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Antacids and gastroprotectants, along with prokinetics, are often recommended for brachycephalics but can be overused (see <b>Potential Adjunct Drugs<\/b>). The American College of Veterinary Internal Medicine has published an in-depth review and consensus statement on the use of these drugs.<sup>13<\/sup> <\/span><\/p>\n<h3 class=\"p3\">Ophthalmic Concerns<\/h3>\n<p class=\"p1\"><span class=\"s1\">Exophthalmos (<a href=\"https:\/\/todaysveterinarypractice.com\/ophthalmology\/ocular-proptosis\/\">proptosis<\/a>) can increase ocular contact with blankets, scrub solution, cage doors, and other items, making corneal ulceration or other eye damage more likely. Patients should be carefully positioned to prevent any external pressure on the eye, and eye lubricant should be liberally applied before, during, and after general anesthesia. <\/span><\/p>\n<h2 class=\"p2\">Considerations in Drug Choice for Brachycephalic Anesthetic Protocols<\/h2>\n<h3 class=\"p3\">Anesthetic and Sedative Drugs<\/h3>\n<p class=\"p1\"><span class=\"s1\">Safe anesthesia for patients with upper airway dysfunction depends more on patient management than on drug choice. Both intubation and extubation can be difficult for the anesthetist and dangerous for the patient. Almost all anesthetic and sedative drugs are acceptable for use in brachycephalic patients, but the most appropriate drugs are those that are fast acting (for rapid intubation), have a short duration of action, and\/or are reversible (for quick return to consciousness and normal breathing) (<\/span><span class=\"s2\"><b>TABLES 2 AND 3<\/b><\/span><span class=\"s1\">). Although considered a longer duration drug, low-dose acepromazine can be a good option for sedation since it provides calming that lasts into recovery.<\/span><\/p>\n<p><a href=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Table2.png\"><img decoding=\"async\" class=\"aligncenter size-full wp-image-31353\" src=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Table2.png\" alt=\"\" width=\"1983\" height=\"1177\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Table2.png 1983w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Table2-300x178.png 300w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Table2-1024x608.png 1024w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Table2-768x456.png 768w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Table2-1536x912.png 1536w\" sizes=\"(max-width: 1983px) 100vw, 1983px\" \/><\/a><\/p>\n<p><a href=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Table3.png\"><img decoding=\"async\" class=\"aligncenter size-full wp-image-31354\" src=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Table3.png\" alt=\"\" width=\"1991\" height=\"1277\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Table3.png 1991w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Table3-300x192.png 300w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Table3-1024x657.png 1024w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Table3-768x493.png 768w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Table3-1536x985.png 1536w\" sizes=\"(max-width: 1991px) 100vw, 1991px\" \/><\/a><\/p>\n<p class=\"p1\"><span class=\"s1\">While there are no drug contraindications, deep sedation, if necessary, should be delayed until the anesthetist is prepared to quickly induce and intubate if sedation causes respiratory difficulty. Light sedation, on the other hand, is beneficial to prevent increased respiratory effort. Drugs and drug dosages that might cause prolonged recovery with subsequent delay to normal breathing are not ideal. <\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Most patients are anesthetized with inhalants (isoflurane, sevoflurane). These drugs cause dose-dependent respiratory and cardiovascular depression that can extend into the recovery period, especially if a high or prolonged dose of inhalants is administered. Use of robust and proactive analgesia is imperative to allow the lowest possible dose of inhalants. <\/span><\/p>\n<h3 class=\"p3\">Analgesic Drugs<\/h3>\n<p class=\"p1\"><span class=\"s1\">Pain control throughout the entire anesthetic episode is critical, as pain is a major contributor to increased respiratory effort. Analgesic drugs and techniques should be incorporated into a balanced, multimodal protocol using knowledge of the drug(s) mechanism of action and site of action in the pain pathway (<\/span><span class=\"s2\"><b>FIGURE 1<\/b><\/span><span class=\"s1\">).<\/span><\/p>\n<div id=\"attachment_31340\" style=\"width: 1919px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig1.png\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-31340\" class=\"size-full wp-image-31340\" src=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig1.png\" alt=\"\" width=\"1909\" height=\"747\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig1.png 1909w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig1-300x117.png 300w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig1-1024x401.png 1024w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig1-768x301.png 768w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig1-1536x601.png 1536w\" sizes=\"(max-width: 1909px) 100vw, 1909px\" \/><\/a><p id=\"caption-attachment-31340\" class=\"wp-caption-text\">Figure 1. The pain pathway with drugs (listed with most potent drug class first) at their site of action for treatment of acute pain. NMDA=N-methyl-D-aspartate. Diagram adapted from Grubb TL, et al. Anesthesia &amp; Pain Management for Veterinary Nurses and Technicians. Teton New Media. 2020. Used with permission from the author. Images: LintangDesign\/shutterstock.com; DwaFotografy\/shutterstock.com.<\/p><\/div>\n<p class=\"p1\"><span class=\"s1\">Opioids are potent analgesics and should be included in most protocols; however, strong focus should also be on nonsedating drugs such as nonsteroidal anti-inflammatory drugs (NSAIDs) and local anesthetics. Analgesic choices are discussed in <strong>TABLE<\/strong><\/span><span class=\"s2\"><b>\u00a04<\/b><\/span><span class=\"s1\">.<\/span><\/p>\n<p><a href=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Table4.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-31355\" src=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Table4.png\" alt=\"\" width=\"2016\" height=\"1259\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Table4.png 2016w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Table4-300x187.png 300w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Table4-1024x639.png 1024w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Table4-768x480.png 768w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Table4-1536x959.png 1536w\" sizes=\"(max-width: 2016px) 100vw, 2016px\" \/><\/a><\/p>\n<h3 class=\"p3\">Potential Adjunct Drugs<\/h3>\n<p class=\"p1\"><span class=\"s1\">Use of the following drugs\/drug classes in anesthetic protocols for brachycephalic patients is somewhat controversial, with no strong expert consensus; however, they are commonly used adjuncts in clinical practice. <\/span><\/p>\n<p class=\"p5\"><b>Anticholinergics<\/b><\/p>\n<p class=\"p1\"><span class=\"s1\">Based on the risk for bradycardia due to exaggerated vagal response, some veterinarians premedicate all brachycephalic dogs with an anticholinergic (atropine or glycopyrrolate), while others use anticholinergics for treatment of bradycardia if it occurs.<sup>19<\/sup> The author does not routinely administer anticholinergics; however, routine anticholinergics can be considered in heart-healthy patients that have not received an <\/span><span class=\"s4\">\u03b1<\/span><span class=\"s1\"><sub>2<\/sub> agonist (e.g., dexmedetomidine), and some effects, such as mild bronchodilation, may be advantageous. <\/span><\/p>\n<p class=\"p5\"><b>Steroids<\/b><\/p>\n<p class=\"p1\"><span class=\"s1\">Airway inflammation in brachycephalics with BOAS is often severe and may require steroids (e.g., dexamethasone-SP 0.1 mg\/kg IV) for control. Due to steroid-mediated effects, many veterinarians recommend steroids for all airway surgeries and potentially for surgeries on other systems if preexisting inflammation is moderate to severe or intubation was difficult and potentially traumatic. <\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Steroids can be administered preoperatively if the presence of moderate to severe inflammation is known or expected, postintubation if intubation was traumatic or if moderate to severe inflammation is identified on visualization of the upper airway during intubation, or in recovery if the patient is having difficulty breathing after extubation. NSAIDs should not be administered preoperatively if steroid use is predicted and are often withheld for use in the recovery phase as long as steroids were not administered.<\/span><\/p>\n<p class=\"p5\"><b>Gastroprotectants and Prokinetics<\/b><\/p>\n<p class=\"p1\"><span class=\"s1\">Due to the strong association of BOAS and GI lesions, gastroprotectants and\/or prokinetics have been recommended for brachycephalic dogs undergoing surgery.<sup>13<\/sup> Histamine blockers, proton pump inhibitors, and promotility drugs (e.g., cisapride, metoclopramide) have all been used with varied success. However, there is no consensus on the routine use of these drugs in brachycephalics and indiscriminate use can be detrimental. The current recommendation is to administer the appropriate drug to dogs showing signs of GI disease, but there is evidence that not all dogs with GI lesions exhibit signs. The author uses protectants in dogs with GI signs and\/or severe BOAS.<\/span><\/p>\n<h2 class=\"p2\">Step-By-Step Anesthesia Management of Brachycephalic Dogs<\/h2>\n<p class=\"p1\"><span class=\"s1\">As for all patients, a plan should be developed prior to anesthetizing the patient and should address the needs and concerns for all 4 phases of anesthesia: preanesthesia, induction, maintenance, and recovery\/discharge. For all phases of anesthesia, focus on airway management\/oxygenation and dose drugs on lean body weight. Keys to successful anesthesia in brachycephalic patients are outlined in <\/span><span class=\"s2\"><b>BOX 2<\/b><\/span><span class=\"s1\">.<\/span><\/p>\n<div class=\"su-box su-box-style-default\" id=\"\" style=\"border-color:#606060;border-radius:3px;\"><div class=\"su-box-title\" style=\"background-color:#939393;color:#FFFFFF;border-top-left-radius:1px;border-top-right-radius:1px\">BOX 2 Keys to Successful Anesthesia in Brachycephalic Dogs<\/div><div class=\"su-box-content su-u-clearfix su-u-trim\" style=\"border-bottom-left-radius:1px;border-bottom-right-radius:1px\">\n<ul>\n<li>Keep patients calm and breathing normally<\/li>\n<li>Prevent aspiration pneumonia secondary to vomiting<\/li>\n<li>Sedate to prevent dyspnea exacerbation and to promote use of lower doses of induction and inhalant drugs to avoid drug-related dose-dependent respiratory depression<\/li>\n<li>Provide preemptive analgesia to promote decreased induction and inhalant drug dosages<\/li>\n<li>Prepare to immediately induce and intubate the patient in the event of an airway emergency<\/div><\/div><\/li>\n<\/ul>\n<h3 class=\"p3\">Phase 1: Preanesthesia<\/h3>\n<p class=\"p1\"><span class=\"s1\"><b>Main concerns and potential complications: <\/b>Increased inspiratory effort with potential for severe dyspnea\/airway collapse leading to hypoxemia, hypercarbia, and hyperthermia. <\/span><\/p>\n<p class=\"p5\"><b>Prior to the Day of Anesthesia <\/b><\/p>\n<ul>\n<li class=\"p6\"><span class=\"s1\">Prepare the patient for safe anesthesia before the anesthetic event. This includes stabilization of any disease processes.<\/span><\/li>\n<li class=\"p7\">The location, extent, and severity of airway compromise should be assessed before the day of anesthesia, if possible, to improve anesthetic safety by allowing the anesthesia team time to adequately prepare. Detailed airway examinations are described elsewhere.<sup>20<\/sup><\/li>\n<li class=\"p7\"><b>Tip:<\/b> Take thoracic radiographs preoperatively. In one study, 40% of dogs with aspiration pneumonia postoperatively had evidence of pneumonia preoperatively.<sup>2<\/sup> Preexisting pneumonia should be treated prior to anesthesia if possible.<\/li>\n<li class=\"p8\">Preexisting GI lesions should also be treated prior to anesthesia if possible.<\/li>\n<\/ul>\n<p class=\"p5\"><b>The Day of Anesthesia at Home<\/b><\/p>\n<ul>\n<li class=\"p7\"><b>Tip:<\/b> To decrease increased respiratory effort and work of breathing from fear\/anxiety\/stress (FAS) in patients already exhibiting FAS or expected to develop FAS at the hospital, have the pet owner administer oral anxiolytics (e.g., gabapentin 10 to 20 mg\/kg or trazodone 3 to 5 mg\/kg) 2 hours prior to leaving home.<\/li>\n<li class=\"p8\"><b>Tip:<\/b> Have the pet owner administer an oral antiemetic (e.g., <a href=\"https:\/\/todaysveterinarypractice.com\/pharmacology\/maropitant-use-in-cats\/\" target=\"_blank\" rel=\"noopener\">maropitant<\/a><sup>21<\/sup>) at home on the day of anesthesia to reduce not only in-clinic causes of vomiting (e.g., administration of emetic drugs like opioids) but also emesis that may occur during transportation to the hospital.<\/li>\n<\/ul>\n<p class=\"p5\"><b>The Day of Anesthesia in the Hospital<\/b><\/p>\n<ul>\n<li class=\"p1\"><span class=\"s1\">Prepare the anesthesia equipment before or immediately after the patient\u2019s arrival at the hospital.<\/span><\/li>\n<li class=\"p6\"><span class=\"s1\">One of the most important safety factors for anesthetizing patients, especially those with airway dysfunction, is to have the necessary anesthesia equipment ready in the event of an airway emergency. <\/span><\/li>\n<li class=\"p7\">Ensure that the oxygen supply is open\/connected, the appropriate breathing circuit is attached to the machine, and the machine\/breathing circuit combination has been pressure-checked.<\/li>\n<li class=\"p7\">Prepare for an emergency intubation.<\/li>\n<li class=\"p9\"><span class=\"s1\">Choose several sizes of endotracheal tubes (ETTs), including several that are smaller than anticipated based on body size (<\/span><span class=\"s2\"><b>FIGURE 2<\/b><\/span><span class=\"s1\">), pressure-check for cuff leaks, and place near the anesthetic machine along with tube lubricant. <\/span><\/li>\n<li class=\"p9\"><span class=\"s1\">Arrange a laryngoscope, ETT stylet, lidocaine for the arytenoids, and gauze for holding the maxilla up to facilitate airway examination and\/or intubation.<\/span><\/li>\n<\/ul>\n<p><a href=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig2A.png\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-31341 aligncenter\" src=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig2A.png\" alt=\"\" width=\"550\" height=\"262\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig2A.png 1120w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig2A-300x143.png 300w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig2A-1024x488.png 1024w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig2A-768x366.png 768w\" sizes=\"(max-width: 550px) 100vw, 550px\" \/><\/a><\/p>\n<div id=\"attachment_31342\" style=\"width: 560px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig2B.png\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-31342\" class=\" wp-image-31342\" src=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig2B.png\" alt=\"\" width=\"550\" height=\"385\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig2B.png 936w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig2B-300x210.png 300w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig2B-768x537.png 768w\" sizes=\"(max-width: 550px) 100vw, 550px\" \/><\/a><p id=\"caption-attachment-31342\" class=\"wp-caption-text\">Figure 2. Approximate endotracheal tube sizes for (A) a 10-kg non-brachycephalic dog (sizes 7, 7.5, 8) and (B) a 10-kg brachycephalic dog (sizes 6, 6.5, 7).<\/p><\/div>\n<p><span style=\"color: #39afc7\"><strong>Patient Handling<\/strong><\/span><\/p>\n<ul>\n<li class=\"p7\">Begin the procedure as soon as possible after the patient arrives at the hospital to minimize the duration of hospital-induced stress.<\/li>\n<li class=\"p7\">During the airway evaluation and\/or preparation for anesthesia, handle the patient quietly and carefully with minimal restraint to avoid increased respiratory effort and hyperthermia.<\/li>\n<li class=\"p7\">Monitor body temperature in stressed patients, especially those experiencing dyspnea.<\/li>\n<li class=\"p7\">Supplemental oxygen should be administered to all patients during handling if breathing is impaired unless the patient resists oxygen delivery. In these patients, the examination should be stopped until the patient is calmer and breathing more normally or until sedatives are administered.<\/li>\n<li class=\"p7\">Patients in respiratory distress should be placed in an oxygen cage if possible.<\/li>\n<li class=\"p8\">Always be prepared for emergency induction and intubation.<\/li>\n<\/ul>\n<p class=\"p10\"><span style=\"color: #39afc7\"><b>Preanesthetic Medication<\/b><\/span><\/p>\n<ul>\n<li class=\"p7\">Choose and administer the appropriate premedicant sedative and dose from <span class=\"s5\"><b>TABLE 2<\/b><\/span> and analgesic from <span class=\"s5\"><b>TABLE<\/b><\/span><span class=\"s5\"><b>\u00a04<\/b><\/span>.<\/li>\n<li class=\"p7\">Sedation is often crucial to prevent dyspnea exacerbation and to promote use of lower doses of induction and inhalant drugs in an effort to avoid drug-related dose-dependent respiratory depression.<\/li>\n<li class=\"p7\">Preemptive analgesia is part of a balanced analgesic protocol and also promotes decreased induction and inhalant drug dosages.<\/li>\n<li class=\"p7\">Intramuscular administration is generally preferred to reduce the need for restraint compared with intravenous administration. However, patients in severe respiratory distress should have an IV catheter in place prior to administering any drugs.<\/li>\n<li class=\"p7\">If not administered at home, maropitant<b> <\/b>should be administered IV or SC at least 60 minutes prior to anesthesia. Maropitant should be stored in the refrigerator to decrease \u201csting\u201d on subcutaneous injection and delivered slowly if administering IV (over 1 to 2 minutes) to prevent maropitant-induced hypotension.<sup>22<\/sup><\/li>\n<li class=\"p7\">Anticholinergics are not necessarily recommended as routine premedicants for all patients, but a dose of either atropine (0.04 mg\/kg) or glycopyrrolate (0.01 to 0.02 mg\/kg) should be calculated in case sudden bradycardia occurs.<\/li>\n<li class=\"p8\">GI protectants may be necessary or recommended.<\/li>\n<\/ul>\n<h3 class=\"p3\">Phase 2: Induction and Intubation<\/h3>\n<p class=\"p6\"><span class=\"s1\"><b>Main concerns and potential complications: <\/b>Difficult intubation or prolonged time to intubation with subsequent hypoxemia and\/or airway collapse and decreased tissue oxygen delivery. See <\/span><span class=\"s2\"><b>BOX 3<\/b><\/span><span class=\"s1\"> for tips for a difficult intubation.<\/span><\/p>\n<ul>\n<li class=\"p7\">Choose appropriate induction drug and dose (<span class=\"s5\"><b>TABLE<\/b><\/span><span class=\"s5\"><b>\u00a03<\/b><\/span>).<b> <\/b><\/li>\n<li class=\"p7\">Be prepared to intubate.<\/li>\n<li class=\"p7\">Preoxygenate to support tissue oxygen delivery<b> <\/b>(<span class=\"s5\"><b>FIGURE 3<\/b><\/span>). Administration of 100% oxygen for as short as 3\u00a0minutes increases the time to desaturation (oxygen saturation [SpO<sub>2<\/sub>] &lt;90%) from approximately 1\u00a0minute to approximately 5 minutes.<sup><sup>25<\/sup><\/sup>\n<p><div id=\"attachment_31343\" style=\"width: 510px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig3.png\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-31343\" class=\" wp-image-31343\" src=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig3.png\" alt=\"\" width=\"500\" height=\"375\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig3.png 864w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig3-300x225.png 300w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig3-768x576.png 768w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><\/a><p id=\"caption-attachment-31343\" class=\"wp-caption-text\">Figure 3. Preoxygenating a brachycephalic dog while the IV catheter is placed. The flange of the mask has been removed to avoid pressure on the eyes.<\/p><\/div><\/li>\n<li class=\"p7\">Administer the induction drug and intubate when the jaw tone is decreased and no swallowing occurs if the pharynx\/larynx is touched with the tube. <i>Do not attempt to intubate if the patient is still swallowing.<\/i> This could cause trauma to an already potentially inflamed\/edematous upper airway.<\/li>\n<li class=\"p7\">The anesthetist should visualize the larynx using a laryngoscope or other light source both to assist with intubation and to evaluate the degree of upper airway pathology, which is important for the anesthetic recovery plan.<\/li>\n<li class=\"p7\">Following intubation, immediately inflate the ETT cuff and connect the ETT to the breathing circuit with oxygen flowing.<\/li>\n<li class=\"p8\">Lubricate the eyes.<\/li>\n<\/ul>\n<div class=\"su-box su-box-style-default\" id=\"\" style=\"border-color:#606060;border-radius:3px;\"><div class=\"su-box-title\" style=\"background-color:#939393;color:#FFFFFF;border-top-left-radius:1px;border-top-right-radius:1px\">BOX 3 Tips for a Difficult Intubation<\/div><div class=\"su-box-content su-u-clearfix su-u-trim\" style=\"border-bottom-left-radius:1px;border-bottom-right-radius:1px\"><\/p>\n<ul>\n<li>Use a laryngoscope for good visualization.<\/li>\n<li>Have an assistant extend the tongue as far as possible from the mouth and use gauze to hold the maxilla so that the holder\u2019s fingers do not obscure the view <strong>(FIGURE A)<\/strong>.\n<p><div id=\"attachment_31349\" style=\"width: 460px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_FigA.png\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-31349\" class=\" wp-image-31349\" src=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_FigA.png\" alt=\"\" width=\"450\" height=\"274\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_FigA.png 1008w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_FigA-300x183.png 300w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_FigA-768x468.png 768w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/><\/a><p id=\"caption-attachment-31349\" class=\"wp-caption-text\">Figure A. Gauze holding the maxilla open.<\/p><\/div><\/li>\n<li>Ensure adequate anesthetic depth. Titrate more induction drug if the patient is swallowing.<\/li>\n<li>Place several drops of lidocaine on each arytenoid and deliver oxygen for 3 minutes while the lidocaine is taking effect.<\/li>\n<li>Place a relatively stiff but bendable stylet in the endotracheal tube (ETT) to give the tube some rigidity to use in lifting the soft palate out of the field of view <strong>(FIGURE B)<\/strong>. Unless the stylet tip is soft, do not extend it beyond the tip or Murphy eye of the ETT.\n<p><div id=\"attachment_31350\" style=\"width: 460px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_FigB.png\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-31350\" class=\" wp-image-31350\" src=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_FigB.png\" alt=\"\" width=\"450\" height=\"149\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_FigB.png 1536w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_FigB-300x99.png 300w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_FigB-1024x339.png 1024w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_FigB-768x255.png 768w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/><\/a><p id=\"caption-attachment-31350\" class=\"wp-caption-text\">Figure B. Bendable stylet in the endotracheal tube. This type of stylet should not be extended beyond the tracheal opening of the endotracheal tube, as it could damage the airway.<\/p><\/div><\/li>\n<li>Lubricate the ETT so it slides easier. Lubrication also aids in achieving an adequate ETT cuff seal to the tracheal wall.<\/li>\n<li>If necessary to obtain a patent airway, place an ETT smaller than desired. When the patient is more deeply anesthetized, attempt to replace the ETT by first inserting a flexible stylet (e.g., red rubber catheter) through the existing tube. Leave the catheter in the airway as the existing ETT is removed and slide a larger ETT over the catheter. This often helps guide the new tube into place.<\/li>\n<li><strong>Advanced tip:<\/strong> Slow IV administration of 1.5 mg\/kg of lidocaine 5 minutes prior to administration of propofol (and likely alfaxalone) decreases the gag and cough reflexes and may make intubation easier.<sup>23<\/sup> This is not always necessary but can be useful.<\/li>\n<li>If all else fails, a tracheotomy can be lifesaving, although it can be difficult in patients with a hypoplastic trachea. This technique is described elsewhere.<sup>24<\/sup><\/li>\n<\/ul>\n<p><\/div><\/div>\n<h3 class=\"p3\">Phase 3: Maintenance<\/h3>\n<p class=\"p1\"><span class=\"s1\"><b>Main concerns and potential complications: <\/b>Excessive anesthetic depth due to inadequate analgesia and difficulty breathing if obese. <\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">The inhalant dose should be kept as low as possible to decrease the negative effect on blood pressure and ventilation and to decrease inhalant effect on prolonged recovery. The procedure should be kept as short as possible, as increasing anesthetic duration has been associated with anesthetic complications.<sup>3<\/sup><\/span><\/p>\n<p class=\"p5\"><b>Anesthesia<\/b><\/p>\n<ul>\n<li class=\"p7\">Choose appropriate maintenance drug and dose.<\/li>\n<li class=\"p7\">Very short procedures may be completed using injectable anesthesia (e.g., ketamine\/benzodiazepine, tiletamine-zolazepam bolus, propofol or alfaxalone infusion), but intubation is required. The procedure time should be kept to an absolute minimum and repeat or prolonged dosing avoided, as drug accumulation could delay recovery, especially if drug metabolism is slowed for any reason. Propofol and alfaxalone cause more respiratory depression than the 2 dissociatives listed but also have shorter duration of action.<\/li>\n<\/ul>\n<p><b>Analgesia<\/b><\/p>\n<ul>\n<li class=\"p7\">Choose appropriate analgesic drug, technique, and dose (<span class=\"s5\"><b>TABLE<\/b><\/span><span class=\"s5\"><b>\u00a04<\/b><\/span>).<\/li>\n<li class=\"p7\">Provision of analgesia is necessary not only for pain control but also to allow use of the lowest possible inhalant dose.<\/li>\n<li class=\"p7\"><i>Use local anesthesia blockade whenever possible.<\/i><b> <\/b>Local anesthetics are very potent analgesics that have numerous benefits for the patient. Local anesthetic blocks are not sedating and so do not compromise return to consciousness. Blockade of the maxillary nerve desensitizes structures often involved in upper airway surgery (e.g., nares, sinuses, soft palate); for surgery in other areas, use appropriate local\/regional blocks. More information on blocks and on local anesthetic drugs is published elsewhere.<sup>16,17 <\/sup><\/li>\n<li class=\"p8\">Constant-rate infusions are also strongly recommended, and an open-access infusion calculator is available.<sup>18<\/sup> Infusions are administered at very low dosages and can provide analgesia with minimal to no sedation. In addition to, or instead of, opioids, which can cause some degree of respiratory depression, ketamine and\/or lidocaine<b> <\/b>(ketamine 10 \u00b5g\/kg\/min; lidocaine 25 to 50 \u00b5g\/kg\/min) should be considered.<\/li>\n<\/ul>\n<p class=\"p5\"><b>Monitoring and Support<\/b><\/p>\n<p class=\"p1\"><span class=\"s1\">Physiologic monitoring and support during maintenance are not specific for BOAS but might include specific monitoring and support for underlying disease. The anesthetist should address all organ systems (e.g., cardiovascular and respiratory systems) and make any corrections necessary to support normal physiologic function (e.g., correction of hypotension and\/or hypoventilation).<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Although the clinical relevance is unknown, brachycephalic animals can have inherently decreased arterial oxygen saturation, increased carbon dioxide levels, and hypertension,<sup>26<\/sup> potentially increasing the likelihood of anesthesia-related adverse events and emphasizing the need for diligent anesthetic monitoring and support. <\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Many brachycephalic patients are also obese, necessitating intermittent or continuous ventilatory support. Ventilation must also be supported if the ETT is significantly smaller than the trachea to avoid excessive work of breathing. Ventilate to an end-tidal CO<sub>2<\/sub> of 35 to 45 mm Hg and SpO<sub>2<\/sub> greater than 95% in patients receiving 98% to 100% supplemental oxygen. More on ventilation of brachycephalics is published elsewhere.<sup>27 <\/sup><\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Body temperature monitoring is critical as hypothermia can contribute to respiratory depression and delayed recovery.<\/span><\/p>\n<h3 class=\"p3\">Phase 4: Recovery and Discharge<\/h3>\n<p class=\"p1\"><span class=\"s1\"><b>Main concerns and potential complications: <\/b>Hypoxemia,<b> <\/b>dyspnea\/apnea, airway collapse\/obstruction in the extubated patient.<\/span><\/p>\n<p class=\"p5\"><b>Recovery<\/b><\/p>\n<ul>\n<li class=\"p1\"><span class=\"s1\">Have a recovery plan for the patient that includes timing of extubation. Recovery is generally the most critical part of the entire anesthetic episode with the highest incidence of adverse effects. <\/span>\n<ul>\n<li class=\"p7\">The patient should be kept calm and pain-free for optimal recovery. Specific drugs for the recovery period might include:<\/li>\n<li class=\"p9\"><span class=\"s1\">Dexmedetomidine (0.0005 to 0.002 mg\/kg) or acepromazine (0.005 to 0.01 mg\/kg). IV administration for fast onset may be beneficial and is necessary in patients experiencing respiratory distress.<\/span><\/li>\n<\/ul>\n<\/li>\n<li class=\"p9\"><span class=\"s1\">Opioids administered at equal to or half of the premedication dose, depending on the level of pain and other analgesics administered.<\/span><\/li>\n<li class=\"p7\">The patient should be kept warm for optimal recovery. Hypothermia will prolong recovery time and return to normal breathing. Shivering increases oxygen consumption, which may not be met by oxygen delivery if the patient cannot breathe, and oxygen debt (inadequate tissue oxygenation) may occur.<\/li>\n<li class=\"p7\">Use the pulse oximeter to monitor adequacy of oxygenation, especially after extubation. If the tongue is not accessible, alternative sites of pulse oximeter probe placement can be used (<span class=\"s5\"><b>FIGURE 4<\/b><\/span>).\n<div id=\"attachment_31344\" style=\"width: 510px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig4A.png\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-31344\" class=\" wp-image-31344\" src=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig4A.png\" alt=\"\" width=\"500\" height=\"375\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig4A.png 864w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig4A-300x225.png 300w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig4A-768x576.png 768w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><\/a><p id=\"caption-attachment-31344\" class=\"wp-caption-text\">Figure 4. Variety of sites for pulse oximeter probe placement. (A) Tongue.<\/p><\/div>\n<div id=\"attachment_31345\" style=\"width: 511px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig4B.png\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-31345\" class=\" wp-image-31345\" src=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig4B.png\" alt=\"\" width=\"501\" height=\"307\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig4B.png 2560w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig4B-300x184.png 300w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig4B-1024x627.png 1024w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig4B-768x470.png 768w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig4B-1536x941.png 1536w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig4B-2048x1254.png 2048w\" sizes=\"(max-width: 501px) 100vw, 501px\" \/><\/a><p id=\"caption-attachment-31345\" class=\"wp-caption-text\">Figure 4. (B) Prepuce (shown) or vulva.<\/p><\/div>\n<div id=\"attachment_31346\" style=\"width: 510px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig4C.png\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-31346\" class=\" wp-image-31346\" src=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig4C.png\" alt=\"\" width=\"500\" height=\"375\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig4C.png 864w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig4C-300x225.png 300w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig4C-768x576.png 768w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><\/a><p id=\"caption-attachment-31346\" class=\"wp-caption-text\">Figure 4. (C) Lip.<\/p><\/div>\n<p><div id=\"attachment_31347\" style=\"width: 510px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig4D.png\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-31347\" class=\" wp-image-31347\" src=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig4D.png\" alt=\"\" width=\"500\" height=\"667\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig4D.png 720w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig4D-225x300.png 225w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><\/a><p id=\"caption-attachment-31347\" class=\"wp-caption-text\">Figure 4. (D) Toe web.<\/p><\/div><\/li>\n<li class=\"p7\"><i>Ensure the patient is fully awake but calm and that pain is alleviated prior to extubating.<\/i><\/li>\n<li class=\"p7\">Brachycephalic patients often still tolerate the ETT when completely conscious and can be carefully extubated at this point (<span class=\"s5\"><b>FIGURE 5<\/b><\/span>).\n<p><div id=\"attachment_31348\" style=\"width: 510px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig5.png\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-31348\" class=\" wp-image-31348\" src=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig5.png\" alt=\"\" width=\"500\" height=\"667\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig5.png 648w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/08\/Grubb_TVPSepOct22_BracycephalicAnesthAnalg_Fig5-225x300.png 225w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><\/a><p id=\"caption-attachment-31348\" class=\"wp-caption-text\">Figure 5. Fully conscious brachycephalic dog with the endotracheal tube still in place.<\/p><\/div><\/li>\n<li class=\"p8\">See <span class=\"s5\"><b>Box 4<\/b><\/span> for tips on treating airway complications after extubation.<\/li>\n<\/ul>\n<div class=\"su-box su-box-style-default\" id=\"\" style=\"border-color:#606060;border-radius:3px;\"><div class=\"su-box-title\" style=\"background-color:#939393;color:#FFFFFF;border-top-left-radius:1px;border-top-right-radius:1px\">BOX 4 Tips to Handle Dyspnea and\/or Desaturation After Extubation<\/div><div class=\"su-box-content su-u-clearfix su-u-trim\" style=\"border-bottom-left-radius:1px;border-bottom-right-radius:1px\">\n<ul>\n<li>If the patient is dyspneic, administer oxygen via the blow-by method or face mask (preferred, but may make the patient struggle) until patient begins breathing normally.<\/li>\n<li>To decide if oxygen can be discontinued, monitor the patient with the pulse oximeter for 5 to 10 minutes after oxygen delivery is stopped. If the patient desaturates (SpO2 &lt;90%), continue providing supplemental oxygen until it is breathing more normally.<\/li>\n<li>Stretch the neck rostrally and gently extend the tongue from the mouth to open the airway. The lips may need to be taped or propped up to further open the airway. Continue to administer oxygen.<\/li>\n<li>Administer steroids (generally dexamethasone-SP 0.1 mg\/kg) if upper airway inflammation is moderate to severe, if intubation was difficult, or if the patient underwent airway surgery, assuming that steroids were not administered preoperatively.<\/li>\n<li>If excessive sedation is present, administer reversal drugs for opioids (butorphanol, naloxone) or \u03b12 agonists (atipamezole), but carefully weigh the excitatory\/pain effects that can occur with reversal. The most prudent path is generally to wait for the patient to metabolize injectable drugs and\/or exhale inhalants. A calm, controlled recovery is ideal. A rapid, excitatory recovery is dangerous.<\/li>\n<li>If reversal is chosen, reverse to effect: Draw up the patient\u2019s dose of naloxone (opioids) or atipamezole (\u03b12 agonists) and dilute with 5 mL of saline. Then slowly administer IV and monitor response until the patient is more alert but not necessarily fully awake. IV administration of atipamezole is off-label.<\/li>\n<li>Always be prepared to reanesthetize and reintubate if the patient cannot breathe.<\/li>\n<li>Reintubation allows time for analgesics, steroids, or other drugs to take effect and for pharyngeal edema and inflammation to resolve. More advanced techniques, such as placing gauze sponges soaked with mannitol on the edematous tissue, can be done in an intubated patient.<sup>2<\/sup><\/li>\n<li>Reintubation also allows the anesthetist to breathe for the patient. This prevents respiratory muscle fatigue secondary to increased work of breathing, which is often a major component of mortality. Inhalants can be used to prolong intubation, as can repeat doses or infusions of propofol or alfaxalone if used for a short duration.<\/li>\n<li>Consider a tracheotomy if the upper airway dysfunction is severe or if the airway is obstructed. This technique is reported elsewhere.<sup>27<\/sup> <\/div><\/div><\/li>\n<\/ul>\n<p class=\"p5\"><b>Discharge<\/b><\/p>\n<ul>\n<li class=\"p7\">Discharge with analgesic drugs and, if needed, anxiolytics.<\/li>\n<li class=\"p7\">NSAIDs are nonsedating and surgical pain is primarily caused by inflammation; therefore, NSAIDs are an excellent choice for pain relief for this group of patients. If perioperative steroids were administered, initiation of NSAID therapy should be delayed as appropriate for the duration of action of the steroid.<\/li>\n<li class=\"p7\">Minimally sedating opioids can be used (e.g., buprenorphine).<\/li>\n<li class=\"p8\">Gabapentin, trazodone, or other anxiolytics should be administered if the patient experiences FAS at home.<\/li>\n<\/ul>\n<div class=\"su-box su-box-style-default\" id=\"\" style=\"border-color:#606060;border-radius:3px;\"><div class=\"su-box-title\" style=\"background-color:#939393;color:#FFFFFF;border-top-left-radius:1px;border-top-right-radius:1px\">KEY POINTS<\/div><div class=\"su-box-content su-u-clearfix su-u-trim\" style=\"border-bottom-left-radius:1px;border-bottom-right-radius:1px\">\n<ul>\n<li>Safe anesthesia for patients with upper airway dysfunction depends more on patient management than on drug choice.<\/li>\n<li>Dogs with concurrent comorbidities or age-related physiologic changes may need drugs or dosages other than those discussed in this article. The overall health of the animal must be considered before choosing anesthetic protocols.<\/li>\n<li>Always be prepared to induce (or reinduce) and intubate (or reintubate) the patient in the event of a respiratory emergency.<\/li>\n<li>Because the recovery phase of anesthesia is the most dangerous, carefully consider how each choice of drugs\/techniques will affect the patient\u2019s recovery.<\/div><\/div><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Brachycephalic obstructive airway syndrome increases the likelihood of anesthesia complications, making appropriate management of these patients critical for anesthetic safety.<\/p>\n","protected":false},"author":236,"featured_media":31351,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"iawp_total_views":20452,"footnotes":""},"categories":[405],"tags":[100,13],"class_list":["post-31446","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-september-october-2022","tag-continuing-education","tag-peer-reviewed","column-continuing-education","column-features","clinical_topics-anesthesiology"],"acf":{"hide_sidebar":false,"hide_sidebar_ad":false,"hide_all_ads":false},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.7 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Anesthesia and Analgesia in Brachycephalic Dogs<\/title>\n<meta name=\"description\" content=\"BOAS increases the likelihood of anesthesia complications, making appropriate management of these patients 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