{"id":31177,"date":"2022-06-17T15:45:22","date_gmt":"2022-06-17T15:45:22","guid":{"rendered":"https:\/\/todaysveterinarypractice.com\/?p=31177"},"modified":"2022-06-20T18:37:13","modified_gmt":"2022-06-20T18:37:13","slug":"robots-to-the-rescue-of-animals","status":"publish","type":"post","link":"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/technology\/robots-to-the-rescue-of-animals\/","title":{"rendered":"Robots to the Rescue of Animals"},"content":{"rendered":"<p class=\"p1\"><span class=\"s1\">Animal testing has resulted in major medical innovations, such as vaccines, antibiotics, and drugs like insulin, but they have come at a high cost paid by the animals involved. Additionally, the majority of such testing often fails to be of any benefit. In 2004, the U.S. Food and Drug Administration <\/span>(FDA) estimated that 92% of drugs that pass preclinical<span class=\"s1\"> tests, including animal tests, do not reach the market. Despite efforts to improve the predictability of animal testing, the failure rate is now closer to 96%.<sup>1<\/sup> A review of treatment <\/span>trials for specific human diseases, such as head injury, respiratory<span class=\"s1\"> distress syndrome, osteoporosis, and stroke, found that the animal experiments accurately predict how they will behave in people only 50% of the time.<sup>1<\/sup><\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">The marketing of drugs and other pharmaceutical products in the U.S. is controlled by the Federal Food, Drug, and Cosmetic Act (FFDCA), which empowers the FDA\u2019s Center for Drug Evaluation and Research to require extensive toxicity testing on animals before a new drug is deemed \u201csafe\u201d for marketing. It typically takes 10 to 15 years and an investment of an average of $1 billion for a new drug to come to market. This antiquated process slows progress, drives up drug costs, and sacrifices countless animals.<\/span><\/p>\n<div class=\"su-quote su-quote-style-default\"><div class=\"su-quote-inner su-u-clearfix su-u-trim\">\u201cWe cannot predict what we might achieve when intelligence is magnified by the tools that AI may provide, but the eradication of war, disease, and poverty would be high on anyone\u2019s list.\u201d \u2014 Stephen Hawking<\/div><\/div>\n<p class=\"p1\"><span class=\"s1\">Efforts to reduce, refine, and replace testing on animals have been making progress over the last decade. Recently, the U.S. Environmental Protection Agency committed to eliminating all mammal study requests and funding by 2035, and the House Energy and Commerce Committee passed the FDA Modernization Act, strengthening the chance of enactment of a measure that would eliminate a statutory animal testing mandate for new drug development and\u00a0reform the drug approval process. An amendment to the FFDCA would allow manufacturers to use alternatives to investigate the safety and effectiveness of a drug.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">So, what are the alternatives? One solution is to use computer models instead\u2014a field which has grown exponentially in recent years and integrates the perspectives of statisticians, toxicologists, biologists, chemists, engineers, and mathematicians to analyze existing data and generate reliable predictions. The use of this artificial intelligence (AI) is now capable of \u201cself-learning\u201d; for instance, using millions of known chemical compounds and data collected in a growing number of accessible databases allows them to predict how a new substance will behave in humans or in the environment, boosting already impressive predictive capabilities. One study has demonstrated that AI could map out previously unknown relationships between molecular structure and specific types of toxicity, such as the effect on the eyes, skin, or DNA.<sup>2<\/sup> While it\u2019s important to be cautious, as the quality of the predictions can be only as good as the information being utilized, the potential is now there for \u201crobots\u201d to save our animals as well as ourselves.<sup>3<\/sup> <\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Animal testing in the human medical field has come at the high price of many lives.<\/p>\n","protected":false},"author":236,"featured_media":16288,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"iawp_total_views":64,"footnotes":""},"categories":[402],"tags":[],"class_list":["post-31177","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-july-august-2022","column-editors-letter","clinical_topics-ethics-welfare","clinical_topics-technology"],"acf":{"hide_sidebar":false,"hide_sidebar_ad":false,"hide_all_ads":false},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.7 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Robots to the Rescue of Animals | Today&#039;s Veterinary Practice<\/title>\n<meta name=\"description\" content=\"Animal testing in the human medical field has come at the high price of many lives. 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