{"id":24847,"date":"2021-12-14T14:22:07","date_gmt":"2021-12-14T14:22:07","guid":{"rendered":"https:\/\/todaysveterinarypractice.com\/?p=24847"},"modified":"2022-03-31T13:40:45","modified_gmt":"2022-03-31T13:40:45","slug":"eyelid-tumors-dogs-cats","status":"publish","type":"post","link":"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/ophthalmology\/eyelid-tumors-dogs-cats\/","title":{"rendered":"Diagnosis and Treatment of Eyelid Tumors"},"content":{"rendered":"<p class=\"p1\"><span class=\"s1\">Eyelid tumors are commonly diagnosed in geriatric veterinary patients and can lead to secondary ocular complications, local invasion, and\/or metastasis. Eyelid tumors can dramatically differ in behavior and treatment strategies between dogs and cats.<span class=\"Apple-converted-space\">\u00a0<\/span><\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">The primary roles of the eyelids are to protect the globe, produce glandular secretions from the meibomian glands and conjunctival goblet cells, and distribute tears across the cornea. An irregular eyelid margin secondary to an eyelid tumor can lead to complications that impair these functions. When the examiner first observes an eyelid tumor, the following things should be considered for planning the type and timing of treatment:<span class=\"Apple-converted-space\">\u00a0<\/span><\/span><\/p>\n<ul>\n<li class=\"p3\">Patient species<span class=\"Apple-converted-space\">\u00a0<\/span><\/li>\n<li class=\"p3\">Size of the mass<span class=\"Apple-converted-space\">\u00a0<\/span><\/li>\n<li class=\"p3\">Duration of the problem and speed of growth<span class=\"Apple-converted-space\">\u00a0<\/span><\/li>\n<li class=\"p3\">Location of the base of the mass (i.e., eyelid margin, dermis, or conjunctiva)<\/li>\n<li class=\"p3\">Ability of the patient to blink fully (to determine need for lubricant to protect the cornea)<\/li>\n<li class=\"p3\">Evidence of local irritation (e.g., ulceration of the dermis, bleeding, conjunctival hyperemia, ocular discharge, corneal vascularization, or corneal ulceration)<\/li>\n<li class=\"p4\">Evidence of metastasis to lymph nodes or elsewhere (indicates need to stage the neoplasia before surgical planning)<\/li>\n<\/ul>\n<h2 class=\"p5\">Eyelid Masses in Dogs<\/h2>\n<p class=\"p1\"><span class=\"s1\">The most common eyelid tumors in dogs are sebaceous (meibomian) adenomas (29% to 37%), sebaceous (meibomian) epitheliomas (17% to 34%), sebaceous (meibomian) hyperplasia (18%), sebaceous (meibomian) adenocarcinomas (5% to 15%), papillomas (2%\u00a0to 17%), melanocytomas\/melanomas (2%\u00a0to 21%), and histiocytomas (1% to 4%).<sup>1,2<\/sup> Note that some, but not all, pathologists differentiate sebaceous hyperplasia from sebaceous adenomas.<sup>3<\/sup> Note also that adenocarcinomas are considered rare, and older data probably misclassified epitheliomas into this category, resulting in increased reporting of adenocarcinomas. Overall, eyelid tumors of dogs are at least 3\u00a0to 8 times more likely to be benign than malignant.<sup>1,4<span class=\"Apple-converted-space\">\u00a0<\/span><\/sup><\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><em>Meibomian gland tumors<\/em> are usually first noticed arising from the eyelid margin because they travel the path of least resistance to the meibomian gland orifice, but they can also erupt through the palpebral conjunctiva (<\/span><strong><span class=\"s2\">FIGURE 1<\/span><\/strong><span class=\"s1\">). They commonly have a cobblestone surface and can be pink, tan, gray, or black (<\/span><strong><span class=\"s2\">FIGURE 2<\/span><\/strong><span class=\"s1\">).<sup>5<\/sup> <em>Sebaceous gland tumors<\/em> can include meibomian gland tumors as well as accessory gland tumors arising from the periocular skin.<sup>3<\/sup> <em>Papillomas<\/em> are often distinctive due to their exophytic nature, arising from the eyelid margin (<\/span><strong><span class=\"s2\">FIGURE 3<\/span><\/strong><span class=\"s1\">), the adjacent dermis, or the conjunctiva; their origin can be viral or nonviral (squamous).<sup>5,6<\/sup> <em>Melanocytic tumors<\/em> of the eyelid can be divided into 3 distinct types: a pigmented pedunculated mass arising from the dermis, which can be excised without concern for margins and is associated with a low rate of recurrence; a pigmented mass arising from the eyelid margin and expanding in both directions, which is more locally invasive than the dermal version and thus benefits from adjunctive treatment such as cryotherapy; and a pigmented or nonpigmented mass arising from the conjunctiva, which is malignant and requires more aggressive treatment.<sup>4<\/sup><span class=\"Apple-converted-space\">\u00a0<\/span><\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><div class=\"su-custom-gallery su-custom-gallery-align-left su-custom-gallery-title-hover su-lightbox-gallery\"><div class=\"su-custom-gallery-slide\" style=\"width:192px;height:192px\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/12\/Foote_TVPJanFeb22_EyelidTumors_Fig1.png\" title=\"Figure 1. Pigmented meibomian gland tumor of the lower eyelid of a dog, which erupted through the eyelid margin as well as the palpebral conjunctiva.\"><img decoding=\"async\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/12\/Foote_TVPJanFeb22_EyelidTumors_Fig1.png\" alt=\"Figure 1. Pigmented meibomian gland tumor of the lower eyelid of a dog, which erupted through the eyelid margin as well as the palpebral conjunctiva.\" width=\"192\" height=\"192\" \/><span class=\"su-custom-gallery-title\">Figure 1. Pigmented meibomian gland tumor of the lower eyelid of a dog, which erupted through the eyelid margin as well as the palpebral conjunctiva.<\/span><\/a><\/div><div class=\"su-custom-gallery-slide\" style=\"width:192px;height:192px\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/12\/Foote_TVPJanFeb22_EyelidTumors_Fig2.png\" title=\"Figure 2. Gray meibomian gland adenoma with a broad base along the upper eyelid margin of a dog. This mass was a regrowth of the same tumor excised with debulking and cryotherapy 2 years earlier; thus, it was subsequently excised with a pentagonal excision with clean margins.\"><img decoding=\"async\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/12\/Foote_TVPJanFeb22_EyelidTumors_Fig2.png\" alt=\"Figure 2. Gray meibomian gland adenoma with a broad base along the upper eyelid margin of a dog. This mass was a regrowth of the same tumor excised with debulking and cryotherapy 2 years earlier; thus, it was subsequently excised with a pentagonal excision with clean margins.\" width=\"192\" height=\"192\" \/><span class=\"su-custom-gallery-title\">Figure 2. Gray meibomian gland adenoma with a broad base along the upper eyelid margin of a dog. This mass was a regrowth of the same tumor excised with debulking and cryotherapy 2 years earlier; thus, it was subsequently excised with a pentagonal excision with clean margins.<\/span><\/a><\/div><div class=\"su-custom-gallery-slide\" style=\"width:192px;height:192px\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/12\/Foote_TVPJanFeb22_EyelidTumors_Fig3.png\" title=\"Figure 3. Papilloma along the lower eyelid margin of a dog, excised with a pentagonal excision with extra care due to the proximity of the nasolacrimal puncta.\"><img decoding=\"async\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/12\/Foote_TVPJanFeb22_EyelidTumors_Fig3.png\" alt=\"Figure 3. Papilloma along the lower eyelid margin of a dog, excised with a pentagonal excision with extra care due to the proximity of the nasolacrimal puncta.\" width=\"192\" height=\"192\" \/><span class=\"su-custom-gallery-title\">Figure 3. Papilloma along the lower eyelid margin of a dog, excised with a pentagonal excision with extra care due to the proximity of the nasolacrimal puncta.<\/span><\/a><\/div><div class=\"su-clear\"><\/div><\/div><\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">A differential diagnosis for an eyelid swelling in a dog is a chalazion caused by blockage of the meibomian gland duct (often but not always caused by a meibomian gland tumor) and inspissation of meibum, sometimes resulting in gland rupture, causing a lipogranuloma (<\/span><strong><span class=\"s2\">FIGURE 4<\/span><\/strong><span class=\"s1\">).<sup>7<\/sup><span class=\"Apple-converted-space\">\u00a0<\/span><\/span><\/p>\n<p class=\"p5\"><div class=\"su-custom-gallery su-custom-gallery-align-left su-custom-gallery-title-hover su-lightbox-gallery\"><div class=\"su-custom-gallery-slide\" style=\"width:300px;height:300px\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/12\/Foote_TVPJanFeb22_EyelidTumors_Fig4A.png\" title=\"Figure 4. (A) Chalazion characterized by a small meibomian gland tumor\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/12\/Foote_TVPJanFeb22_EyelidTumors_Fig4A.png\" alt=\"Figure 4. (A) Chalazion characterized by a small meibomian gland tumor\" width=\"300\" height=\"300\" \/><span class=\"su-custom-gallery-title\">Figure 4. (A) Chalazion characterized by a small meibomian gland tumor<\/span><\/a><\/div><div class=\"su-custom-gallery-slide\" style=\"width:300px;height:300px\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/12\/Foote_TVPJanFeb22_EyelidTumors_Fig4B.png\" title=\"Figure 4. (B) a swelling through the eyelid stroma noted on the dermal surface and under the conjunctiva.\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/12\/Foote_TVPJanFeb22_EyelidTumors_Fig4B.png\" alt=\"Figure 4. (B) a swelling through the eyelid stroma noted on the dermal surface and under the conjunctiva.\" width=\"300\" height=\"300\" \/><span class=\"su-custom-gallery-title\">Figure 4. (B) a swelling through the eyelid stroma noted on the dermal surface and under the conjunctiva.<\/span><\/a><\/div><div class=\"su-custom-gallery-slide\" style=\"width:300px;height:300px\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/12\/Foote_TVPJanFeb22_EyelidTumors_Fig4C.png\" title=\"Figure 4.  After excision of the conjunctiva, a large amount of inspissated meibum was expressed (C), the mass was debulked at the level of the eyelid margin, and the conjunctiva was treated with cryotherapy.\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/12\/Foote_TVPJanFeb22_EyelidTumors_Fig4C.png\" alt=\"Figure 4.  After excision of the conjunctiva, a large amount of inspissated meibum was expressed (C), the mass was debulked at the level of the eyelid margin, and the conjunctiva was treated with cryotherapy.\" width=\"300\" height=\"300\" \/><span class=\"su-custom-gallery-title\">Figure 4.  After excision of the conjunctiva, a large amount of inspissated meibum was expressed (C), the mass was debulked at the level of the eyelid margin, and the conjunctiva was treated with cryotherapy.<\/span><\/a><\/div><div class=\"su-custom-gallery-slide\" style=\"width:300px;height:300px\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/12\/Foote_TVPJanFeb22_EyelidTumors_Fig4D.png\" title=\"Figure 4. (D) Two weeks postoperatively, the eyelid appeared normal.\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/12\/Foote_TVPJanFeb22_EyelidTumors_Fig4D.png\" alt=\"Figure 4. (D) Two weeks postoperatively, the eyelid appeared normal.\" width=\"300\" height=\"300\" \/><span class=\"su-custom-gallery-title\">Figure 4. (D) Two weeks postoperatively, the eyelid appeared normal.<\/span><\/a><\/div><div class=\"su-clear\"><\/div><\/div><\/p>\n<h2 class=\"p5\">Eyelid Masses in Cats<\/h2>\n<p class=\"p1\"><span class=\"s1\">Up to 91% of eyelid tumors in cats are malignant;<sup>8,9<\/sup> thus, they require a more urgent diagnostic and treatment plan. The most common eyelid tumors of cats are squamous cell carcinomas (28% to 65%), mastocytomas (3% to 26%), hemangiosarcomas (2% to 14%), lymphomas (7% to 11%), adenocarcinomas (4%\u00a0to 9%), peripheral nerve sheath tumors (7%), fibrosarcomas (5%), and apocrine hidrocystomas (3%\u00a0to 7%). <i>Squamous cell carcinomas<\/i> develop secondary to ultraviolet light exposure; they start off as an erythematous region of the eyelid margin, progress to ulceration with a crusted surface (<\/span><strong><span class=\"s2\">FIGURE\u00a05<\/span><\/strong><span class=\"s1\">), and then progress further to a deep erosion (<\/span><strong><span class=\"s2\">FIGURE 6<\/span><\/strong><span class=\"s1\">). Local invasion can be extensive if not addressed early in the disease process, and tumor recurrence is very common.<sup>10<\/sup> <i>Mast cell tumors<\/i> appear as single, pink, hairless, raised, and sometimes ulcerated masses near the eyelid margin.<sup>11<\/sup> <i>Hemangiosarcomas<\/i> of the eyelid appear as a red fleshy mass, sometimes with an ulcerated surface.<sup>12<\/sup> <i>Peripheral nerve sheath tumors<\/i> are low-grade subcutaneous spindle cell tumors that are locally invasive but unlikely to metastasize.<sup>10<\/sup> <i>Apocrine hidrocystomas<\/i> appear as black round periocular masses, most common in Persian cats.<sup>10<\/sup><span class=\"Apple-converted-space\">\u00a0<\/span><\/span><\/p>\n<p class=\"p5\"><div class=\"su-custom-gallery su-custom-gallery-align-left su-custom-gallery-title-hover su-lightbox-gallery\"><div class=\"su-custom-gallery-slide\" style=\"width:300px;height:300px\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/12\/Foote_TVPJanFeb22_EyelidTumors_Fig5.png\" title=\"Figure 5. White-faced cat with ulcerated crusting lesions on the medial and central portions of the lower left eyelid and on the right side of the nose, presumptively diagnosed as squamous cell carcinoma at the time of examination and confirmed with histopathology.\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/12\/Foote_TVPJanFeb22_EyelidTumors_Fig5.png\" alt=\"Figure 5. White-faced cat with ulcerated crusting lesions on the medial and central portions of the lower left eyelid and on the right side of the nose, presumptively diagnosed as squamous cell carcinoma at the time of examination and confirmed with histopathology.\" width=\"300\" height=\"300\" \/><span class=\"su-custom-gallery-title\">Figure 5. White-faced cat with ulcerated crusting lesions on the medial and central portions of the lower left eyelid and on the right side of the nose, presumptively diagnosed as squamous cell carcinoma at the time of examination and confirmed with histopathology.<\/span><\/a><\/div><div class=\"su-custom-gallery-slide\" style=\"width:300px;height:300px\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/12\/Foote_TVPJanFeb22_EyelidTumors_Fig6.png\" title=\"Figure 6. Advanced deep, erosive squamous cell carcinoma of the medial canthus of the left eye in a poorly pigmented cat. Courtesy Iowa State University College of Veterinary Medicine.\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/12\/Foote_TVPJanFeb22_EyelidTumors_Fig6.png\" alt=\"Figure 6. Advanced deep, erosive squamous cell carcinoma of the medial canthus of the left eye in a poorly pigmented cat. Courtesy Iowa State University College of Veterinary Medicine.\" width=\"300\" height=\"300\" \/><span class=\"su-custom-gallery-title\">Figure 6. Advanced deep, erosive squamous cell carcinoma of the medial canthus of the left eye in a poorly pigmented cat. Courtesy Iowa State University College of Veterinary Medicine.<\/span><\/a><\/div><div class=\"su-clear\"><\/div><\/div><\/p>\n<h2 class=\"p5\">Conjunctival Masses in Dogs and Cats<\/h2>\n<p class=\"p1\"><span class=\"s1\">For either species, the prognosis for tumors arising from the conjunctiva (including the third eyelid) is generally worse than that for their counterparts of dermal and sebaceous gland origin due to local invasion, high recurrence rates, and likelihood of metastasis.<sup>13,14<\/sup> One exception is the conjunctival papilloma in dogs, which, similar to papillomas of dermal origin, behaves benignly.<sup>6<\/sup> Other common conjunctival tumors include squamous cell carcinomas, mast cell tumors, hemangiosarcomas, adenocarcinomas, lymphomas, and melanomas.<sup>14-17<\/sup><\/span><\/p>\n<h2 class=\"p5\">Diagnosis of Eyelid Tumors<\/h2>\n<p class=\"p1\"><span class=\"s1\">Most eyelid tumors are associated with clinical features and characteristics that can support a presumptive diagnosis and guide the clinician to the next step. However, sometimes a fine-needle aspirate or punch biopsy can be helpful for formulating a diagnostic and treatment plan, especially for masses that do not have a typical appearance or are suspected to be malignant. Thus, these diagnostics are most often used for cats or for tumors arising from the dermis or conjunctiva in dogs before formulating a surgical plan. Because only histologic examination can reveal the definitive diagnosis, all resected tumors should be submitted for histopathology, even if suspected to be benign.<span class=\"Apple-converted-space\">\u00a0<\/span><\/span><\/p>\n<h2 class=\"p5\">Treatment of Eyelid Tumors<\/h2>\n<p class=\"p1\"><span class=\"s1\">Therapy should be tailored to ocular examination findings (location, degree of irritation to the skin and cornea, rate of growth); the presumptive or cytologic diagnosis; the patient\u2019s systemic status; previous responses to therapy, if applicable; available equipment; and the client\u2019s concerns. Treatment for eyelid tumors usually consists of resection en bloc (including the skin and eyelid margin) with appropriate margins for the expected mass or resection plus cryotherapy or other adjunctive therapy.<\/span><\/p>\n<h3 class=\"p6\">Eyelid Surgery<\/h3>\n<p class=\"p1\"><span class=\"s1\">In general, eyelid neoplasia is best treated early, when the tumor is small, because the amount of tissue that can be removed without extensive reconstruction is finite. Typically, 25% to 33% of the eyelid length can be removed while still enabling primary closure; however, this percentage is highly variable, depending on the breed conformation.<sup>18<\/sup> Before surgery, eyelids should be washed with dilute baby shampoo to remove dirt, after which a 1:50 dilution of povidone-iodine solution can be applied to the eyelids and conjunctival fornix with cotton-tipped applicators. The patient should be in sternal position with the head straight and the palpebral fissure horizontal. Drapes should be secured in such a way that they do not distort the eyelids. During closure, suture material should never pass through the conjunctiva, all knots and tags should point away from the eyelid margin and palpebral conjunctiva, and 5-0 or 6-0 soft sutures (e.g., silk or polyglactin 910) should be used. Use of an Elizabethan collar is essential to prevent self-trauma, which can lead to loosened sutures, wound dehiscence, and\/or infection.<sup>4<span class=\"Apple-converted-space\">\u00a0<\/span><\/sup><\/span><\/p>\n<p class=\"p7\"><strong>Dogs<\/strong><\/p>\n<p class=\"p1\"><span class=\"s1\">In dogs, eyelid margin masses are best treated with simple full-thickness surgical excision or removal of the mass to the base (debulking) followed by cryotherapy. Generally, if the tumor is pedunculated, debulking and cryotherapy are sufficient; however, if the tumor is mainly within the stroma of the eyelid, then a wedge or pentagonal (\u201chouse\u201d) resection is preferred. Surgical excision should include 0.5- to 1-mm margins around the mass, followed by closure.<span class=\"Apple-converted-space\">\u00a0<\/span><\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Debulking and cryotherapy involve sedation (or general anesthesia) plus approximately 0.2 to 0.3 mL of local anesthetic; a chalazion clamp to aid in stabilization, hemostasis, and the desired \u201cslow thaw\u201d; excision of the mass as close to the base as possible; +\/- partial-thickness excision over the adjacent conjunctiva to curette the inspissated sebaceous debris (chalazion) and\/or mass material with cotton-tipped applicators or a curette cup; and application of the cryoprobe on the conjunctiva at the level of the meibomian gland (3 mm distal to the eyelid margin) or on the skin if the mass was predominantly dermal. Cryotherapy involves 2 to 3\u00a0cycles of rapid freezing (approximately 25 to 40\u00a0seconds) until an ice ball is formed up to the level of the eyelid margin, followed by slow thawing (at least 60\u00a0seconds) (<\/span><strong><span class=\"s2\">FIGURES 7 AND 8<\/span><\/strong><span class=\"s1\">).<sup>4,19<span class=\"Apple-converted-space\">\u00a0<\/span><\/sup><\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><div class=\"su-custom-gallery su-custom-gallery-align-left su-custom-gallery-title-hover su-lightbox-gallery\"><div class=\"su-custom-gallery-slide\" style=\"width:192px;height:192px\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/12\/Foote_TVPJanFeb22_EyelidTumors_Fig7A.png\" title=\"Figure 7. (A) Eyelid margin melanocytoma on the central lower right eyelid of a dog\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/12\/Foote_TVPJanFeb22_EyelidTumors_Fig7A.png\" alt=\"Figure 7. (A) Eyelid margin melanocytoma on the central lower right eyelid of a dog\" width=\"192\" height=\"192\" \/><span class=\"su-custom-gallery-title\">Figure 7. (A) Eyelid margin melanocytoma on the central lower right eyelid of a dog<\/span><\/a><\/div><div class=\"su-custom-gallery-slide\" style=\"width:192px;height:192px\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/12\/Foote_TVPJanFeb22_EyelidTumors_Fig7B.png\" title=\"Figure 7. (A) Eyelid margin melanocytoma on the central lower right eyelid of a dog with (B) a narrow base at the eyelid margin.\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/12\/Foote_TVPJanFeb22_EyelidTumors_Fig7B.png\" alt=\"Figure 7. (A) Eyelid margin melanocytoma on the central lower right eyelid of a dog with (B) a narrow base at the eyelid margin.\" width=\"192\" height=\"192\" \/><span class=\"su-custom-gallery-title\">Figure 7. (A) Eyelid margin melanocytoma on the central lower right eyelid of a dog with (B) a narrow base at the eyelid margin.<\/span><\/a><\/div><div class=\"su-custom-gallery-slide\" style=\"width:192px;height:192px\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/12\/Foote_TVPJanFeb22_EyelidTumors_Fig7C.png\" title=\"Figure 7. (C) After a chalazion clamp was placed, the mass was excised while still preserving the eyelid margin\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/12\/Foote_TVPJanFeb22_EyelidTumors_Fig7C.png\" alt=\"Figure 7. (C) After a chalazion clamp was placed, the mass was excised while still preserving the eyelid margin\" width=\"192\" height=\"192\" \/><span class=\"su-custom-gallery-title\">Figure 7. (C) After a chalazion clamp was placed, the mass was excised while still preserving the eyelid margin<\/span><\/a><\/div><div class=\"su-custom-gallery-slide\" style=\"width:192px;height:192px\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/12\/Foote_TVPJanFeb22_EyelidTumors_Fig7D.png\" title=\"Figure 7. After a chalazion clamp was placed, the mass was excised while still preserving the eyelid margin (C) and then treated with cryotherapy over the base of the mass (D). No regrowth was noted at 6 months.\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/12\/Foote_TVPJanFeb22_EyelidTumors_Fig7D.png\" alt=\"Figure 7. After a chalazion clamp was placed, the mass was excised while still preserving the eyelid margin (C) and then treated with cryotherapy over the base of the mass (D). No regrowth was noted at 6 months.\" width=\"192\" height=\"192\" \/><span class=\"su-custom-gallery-title\">Figure 7. After a chalazion clamp was placed, the mass was excised while still preserving the eyelid margin (C) and then treated with cryotherapy over the base of the mass (D). No regrowth was noted at 6 months.<\/span><\/a><\/div><div class=\"su-custom-gallery-slide\" style=\"width:192px;height:192px\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/12\/Foote_TVPJanFeb22_EyelidTumors_Fig8A.png\" title=\"Figure 8. (A) Eyelid margin meibomian gland adenoma treated with sharp excision preserving the eyelid margin,\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/12\/Foote_TVPJanFeb22_EyelidTumors_Fig8A.png\" alt=\"Figure 8. (A) Eyelid margin meibomian gland adenoma treated with sharp excision preserving the eyelid margin,\" width=\"192\" height=\"192\" \/><span class=\"su-custom-gallery-title\">Figure 8. (A) Eyelid margin meibomian gland adenoma treated with sharp excision preserving the eyelid margin,<\/span><\/a><\/div><div class=\"su-custom-gallery-slide\" style=\"width:192px;height:192px\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/12\/Foote_TVPJanFeb22_EyelidTumors_Fig8B.png\" title=\"Figure 8. (B) Cryotherapy of the conjunctival surface over the meibomian gland to kill remaining tumor within the eyelid. No regrowth was noted at 1 year.\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/12\/Foote_TVPJanFeb22_EyelidTumors_Fig8B.png\" alt=\"Figure 8. (B) Cryotherapy of the conjunctival surface over the meibomian gland to kill remaining tumor within the eyelid. No regrowth was noted at 1 year.\" width=\"192\" height=\"192\" \/><span class=\"su-custom-gallery-title\">Figure 8. (B) Cryotherapy of the conjunctival surface over the meibomian gland to kill remaining tumor within the eyelid. No regrowth was noted at 1 year.<\/span><\/a><\/div><div class=\"su-clear\"><\/div><\/div><\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Cryotherapy treats the remaining tumor within the eyelid stroma that cannot be visualized. Debulking without cryotherapy has limited benefit and is not recommended. The benefits of debulking and cryotherapy include a shorter procedure, use of sedation and local anesthesia only, and lack of need for sutures (thus, no postoperative need for an Elizabethan collar). In addition, liquid nitrogen delivery systems are inexpensive and have a good return on investment. Disadvantages of cryotherapy include postoperative swelling, temporary tissue depigmentation, and unwanted damage to normal tissue.<sup>4,7<\/sup> Recurrence rates for wedge resection versus debulking and cryotherapy of eyelid margin tumors are similar (approximately 11% to 15%).<sup>19<\/sup> Surgical removal of eyelid margin masses with a CO\u2082 laser has also been reported but can lead to a defect in the eyelid margin. Thus, the laser is best for masses with a small base; if the base is larger, the laser can serve as the blade and the defect can be closed primarily as a wedge resection.<sup>4<\/sup> Dermal and conjunctival tumors may require removal of larger margins and more involved planning. Any removed mass should always be submitted for biopsy. The histopathology will help determine treatment of a recurring mass (e.g., a <\/span>different surgical approach or removal of larger margins).<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p class=\"p7\"><strong>Cats<\/strong><\/p>\n<p class=\"p1\"><span class=\"s1\">In cats, a squamous cell carcinoma is best managed by complete excision with wide (4 to 5 mm) surgical margins, which can sometimes dictate enucleation of a visual, healthy eye.<sup>10<\/sup> Ways to help manage the missing tissue include creating a lip-to-lid subdermal plexus <\/span>flap, a local transposition flap, or a caudal auricular axial<span class=\"s1\"> pattern flap.<sup>20-22<\/sup> When resection alone will not slow <\/span>tumor progression, debulking combined with adjunctive<span class=\"s1\"> therapy can be used. Adjunctive therapies include <\/span>cryotherapy, beta radiation therapy (local strontium-90), <span class=\"s1\">photodynamic therapy, and electrochemotherapy;<sup>10,14,23<\/sup> however, none of these treatments penetrates deep into the tissue. Peripheral nerve sheath tumors usually require removal of wide surgical margins, involving removal of the eye, because nearly all conservatively treated tumors will recur.<sup>10<\/sup> Fortunately, mast cell tumors often respond well to surgical removal, even with incomplete margins.<sup>11<\/sup> Apocrine hidrocystomas can be incised, drained, and then treated with cryosurgery or photoablation if the <\/span>masses are causing irritation to the patient. Alternatively,<span class=\"s1\"> drainage and injection with polidocanol can be effective. Although these tumors are benign, recurrence or formation of new cysts is common; thus, benign neglect is an option for masses not causing a clinical concern.<\/span><\/p>\n<h3 class=\"p6\">Advanced Procedures<\/h3>\n<p class=\"p1\"><span class=\"s1\">Among tumors that are more difficult to treat are those at the level of the medial canthus, near the lacrimal puncta. The author recommends that while excising the mass, the canaliculi be marked by canulating the puncta with a 24-gauge IV catheter. If the base of the mass plus the margins desired are more than 33% of the total length of the eyelid or if there is too much tension at the primary closure site, a reconstructive blepharoplasty surgery should be chosen. Several procedures, beyond the scope of this article, can be considered if a larger area needs to be excised, including the \u201chouse-inverted-triangle\u201d; sliding H-figure blepharoplasty; and other rotation, sliding, or full-thickness skin or myocutaneous grafts.<sup>4,7,24<span class=\"Apple-converted-space\">\u00a0<\/span><\/sup><\/span><\/p>\n<h2 class=\"p5\">Summary<\/h2>\n<p class=\"p1\"><span class=\"s1\">In dogs, eyelid tumors are very common; fortunately, most are likely to be benign. Debulking plus cryotherapy, CO<sub>2<\/sub> laser, and surgical pentagonal excision are all appropriate treatments for removing eyelid margin masses in dogs. For masses that are smooth and within the eyelid dermis or conjunctiva, a fine-needle aspirate or punch biopsy is helpful for determining a treatment plan. In cats, eyelid tumors are not nearly as common but are often malignant. For all eyelid tumors, early intervention and histopathologic examination are advisable.<span class=\"Apple-converted-space\">\u00a0<\/span><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Eyelid tumors can dramatically differ in behavior and treatment strategies between dogs and cats.<\/p>\n","protected":false},"author":9,"featured_media":24777,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"iawp_total_views":23816,"footnotes":""},"categories":[319],"tags":[13],"class_list":["post-24847","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-january-february-2022","tag-peer-reviewed","column-features","clinical_topics-ophthalmology"],"acf":{"hide_sidebar":false,"hide_sidebar_ad":false,"hide_all_ads":false},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.7 (Yoast SEO v27.3) - 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