{"id":23164,"date":"2021-04-09T13:14:45","date_gmt":"2021-04-09T13:14:45","guid":{"rendered":"https:\/\/todaysveterinarypractice.com\/?p=23164"},"modified":"2022-04-29T14:20:51","modified_gmt":"2022-04-29T14:20:51","slug":"diagnostic-approach-to-the-pruritic-dog","status":"publish","type":"post","link":"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/dermatology\/diagnostic-approach-to-the-pruritic-dog\/","title":{"rendered":"Diagnostic Approach to the Pruritic Dog"},"content":{"rendered":"<p class=\"p1\"><span class=\"s1\">Pruritus is one of the most common reasons why clients bring their dog to the veterinarian. Sometimes the cause of the pruritus is obvious (e.g., the dog is covered with fleas), and sometimes it is not so simple. The patient\u2019s primary condition may be exacerbated by secondary infections or development of (new) allergic skin diseases. If necessary, the veterinarian must be ready to \u201cpeel back\u201d diagnostic layers to get to the underlying cause\u2014or causes. This article provides a logical approach to the workup of the pruritic dog.<\/span><\/p>\n<h2 class=\"p2\">Major Categories of Conditions Responsible for Pruritus<\/h2>\n<p class=\"p1\"><span class=\"s1\">Although there are definitely exceptions, most conditions responsible for pruritus in the dog fall into 3 broad categories: infection, infestation\/ectoparasitism, and allergy (<\/span><strong><span class=\"s2\">TABLES 1-3<\/span><\/strong><span class=\"s1\">).<sup>1-9<\/sup> Frequently, conditions in more than 1 category are present simultaneously (e.g., the patient with atopic dermatitis may also have fleas and a secondary yeast infection). Furthermore, the sensation of pruritus can be considered to be an additive phenomenon in which each condition builds on the discomfort generated by the other(s).<\/span><\/p>\n<h3 class=\"p3\">Infection<\/h3>\n<p class=\"p1\"><span class=\"s1\">The most common infectious conditions that can be associated with pruritus in the dog are staphylococcal pyoderma and yeast dermatitis (typically <i>Malassezia<\/i>, although <i>Candida<\/i> may also be seen, albeit rarely).<sup>9<\/sup> Dermatophytosis may also be associated with pruritus, although less commonly than bacterial and yeast disorders.<sup>9<\/sup> With the exception of dermatophytosis, infection is generally a secondary cause of pruritus.<sup>10<\/sup> However, any microbial overgrowth or invasion can trigger production of a nonspecific inflammatory response in the skin by activating and recruiting inflammatory cells, which subsequently release inflammatory and pruritogenic substances. Together, these events induce or enhance the sensation of pruritus.<sup>11<\/sup> <\/span><strong><span class=\"s2\">TABLE 1<\/span><\/strong><span class=\"s1\"> describes the most common infectious causes of pruritus and their distributions.<\/span><\/p>\n<p><a href=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Table1.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"aligncenter size-full wp-image-23104\" src=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Table1.jpg\" alt=\"\" width=\"2163\" height=\"1126\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Table1.jpg 2163w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Table1-300x156.jpg 300w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Table1-1024x533.jpg 1024w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Table1-768x400.jpg 768w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Table1-1536x800.jpg 1536w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Table1-2048x1066.jpg 2048w\" sizes=\"(max-width: 2163px) 100vw, 2163px\" \/><\/a><\/p>\n<div id=\"attachment_23092\" style=\"width: 402px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Fig1.jpg\"><img decoding=\"async\" aria-describedby=\"caption-attachment-23092\" class=\"wp-image-23092 \" src=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Fig1.jpg\" alt=\"\" width=\"392\" height=\"523\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Fig1.jpg 621w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Fig1-225x300.jpg 225w\" sizes=\"(max-width: 392px) 100vw, 392px\" \/><\/a><p id=\"caption-attachment-23092\" class=\"wp-caption-text\">Figure 1. Brown discoloration on the claw of a dog with yeast pododermatitis.<\/p><\/div>\n<h3 class=\"p3\">Infestation\/Ectoparasitism<\/h3>\n<p class=\"p4\"><span class=\"s1\">Parasites typically associated with the development or perpetuation of pruritus in the dog can be classified into those infesting the skin surface, the superficial aspect of the skin (e.g., the stratum corneum and epidermis), or the deep portions of the skin (especially the follicles).<sup>6<span class=\"Apple-converted-space\">\u00a0<\/span><\/sup><\/span><\/p>\n<ul>\n<li class=\"p5\">Surface-dwelling parasites include fleas, lice, <i>Otodectes<\/i> and <i>Cheyletiella<\/i> mites, and chiggers (<i>Eutrombicula, Walchia<\/i>).<\/li>\n<li class=\"p5\">Superficial parasites include <i>Sarcoptes<\/i> mites.<\/li>\n<li class=\"p6\">Deep-dwelling parasites include <i>Demodex canis<\/i> and <i>Demodex injai<\/i> mites.<\/li>\n<\/ul>\n<p class=\"p1\"><span class=\"s1\">Other insects and mites may also contribute to pruritus through means other than direct parasitism, including mosquitoes, stable flies (<i>Stomoxys<\/i>), and black flies (<i>Simulium<\/i>). <\/span><strong><span class=\"s2\">TABLE 2<\/span><\/strong><span class=\"s1\"> describes the typical clinical appearance and distribution of dermatitis associated with parasites as well as relevant diagnostic techniques.<\/span><\/p>\n<p><a href=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Table2-scaled-1.jpg\"><img decoding=\"async\" class=\"aligncenter size-full wp-image-23105\" src=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Table2-scaled-1.jpg\" alt=\"\" width=\"2014\" height=\"2560\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Table2-scaled-1.jpg 2014w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Table2-scaled-1-236x300.jpg 236w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Table2-scaled-1-806x1024.jpg 806w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Table2-scaled-1-768x976.jpg 768w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Table2-scaled-1-1208x1536.jpg 1208w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Table2-scaled-1-1611x2048.jpg 1611w\" sizes=\"(max-width: 2014px) 100vw, 2014px\" \/><\/a><\/p>\n<div class=\"su-custom-gallery su-custom-gallery-align-left su-custom-gallery-title-hover su-lightbox-gallery\"><div class=\"su-custom-gallery-slide\" style=\"width:192px;height:192px\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Fig2A.jpg\" target=\"_blank\" title=\"Figure 2A. Hyperpigmentation, lichenification, and comedones on the ventral abdomen (A) and antebrachium (B) of a dog with demodicosis. This dog received treatment with oclacitinib for months along with increasing doses of glucocorticoids for allergic dermatitis.\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Fig2A.jpg\" alt=\"Figure 2A. Hyperpigmentation, lichenification, and comedones on the ventral abdomen (A) and antebrachium (B) of a dog with demodicosis. This dog received treatment with oclacitinib for months along with increasing doses of glucocorticoids for allergic dermatitis.\" width=\"192\" height=\"192\" \/><span class=\"su-custom-gallery-title\">Figure 2A. Hyperpigmentation, lichenification, and comedones on the ventral abdomen (A) and antebrachium (B) of a dog with demodicosis. This dog received treatment with oclacitinib for months along with increasing doses of glucocorticoids for allergic dermatitis.<\/span><\/a><\/div><div class=\"su-custom-gallery-slide\" style=\"width:192px;height:192px\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Fig2B.jpg\" target=\"_blank\" title=\"Figure 2B. Hyperpigmentation, lichenification, and comedones on the ventral abdomen (A) and antebrachium (B) of a dog with demodicosis. This dog received treatment with oclacitinib for months along with increasing doses of glucocorticoids for allergic dermatitis.\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Fig2B.jpg\" alt=\"Figure 2B. Hyperpigmentation, lichenification, and comedones on the ventral abdomen (A) and antebrachium (B) of a dog with demodicosis. This dog received treatment with oclacitinib for months along with increasing doses of glucocorticoids for allergic dermatitis.\" width=\"192\" height=\"192\" \/><span class=\"su-custom-gallery-title\">Figure 2B. Hyperpigmentation, lichenification, and comedones on the ventral abdomen (A) and antebrachium (B) of a dog with demodicosis. This dog received treatment with oclacitinib for months along with increasing doses of glucocorticoids for allergic dermatitis.<\/span><\/a><\/div><div class=\"su-custom-gallery-slide\" style=\"width:192px;height:192px\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Fig3A.jpg\" target=\"_blank\" title=\"Figure 3A. Demodex canis photographed with the microscope condenser down (A) and up (B). Note the marked increase in clarity and contrast when the microscope condenser is lowered.\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Fig3A.jpg\" alt=\"Figure 3A. Demodex canis photographed with the microscope condenser down (A) and up (B). Note the marked increase in clarity and contrast when the microscope condenser is lowered.\" width=\"192\" height=\"192\" \/><span class=\"su-custom-gallery-title\">Figure 3A. Demodex canis photographed with the microscope condenser down (A) and up (B). Note the marked increase in clarity and contrast when the microscope condenser is lowered.<\/span><\/a><\/div><div class=\"su-custom-gallery-slide\" style=\"width:192px;height:192px\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Fig3B.jpg\" target=\"_blank\" title=\"Figure 3B. Demodex canis photographed with the microscope condenser down (A) and up (B). Note the marked increase in clarity and contrast when the microscope condenser is lowered.\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Fig3B.jpg\" alt=\"Figure 3B. Demodex canis photographed with the microscope condenser down (A) and up (B). Note the marked increase in clarity and contrast when the microscope condenser is lowered.\" width=\"192\" height=\"192\" \/><span class=\"su-custom-gallery-title\">Figure 3B. Demodex canis photographed with the microscope condenser down (A) and up (B). Note the marked increase in clarity and contrast when the microscope condenser is lowered.<\/span><\/a><\/div><div class=\"su-custom-gallery-slide\" style=\"width:192px;height:192px\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Fig4.jpg\" target=\"_blank\" title=\"Figure 4. Deep skin scraping demonstrating adult Demodex mites (orange arrows), mite fragments (blue arrows), a nymph (black arrow), and an egg (yellow arrow).\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Fig4.jpg\" alt=\"Figure 4. Deep skin scraping demonstrating adult Demodex mites (orange arrows), mite fragments (blue arrows), a nymph (black arrow), and an egg (yellow arrow).\" width=\"192\" height=\"192\" \/><span class=\"su-custom-gallery-title\">Figure 4. Deep skin scraping demonstrating adult Demodex mites (orange arrows), mite fragments (blue arrows), a nymph (black arrow), and an egg (yellow arrow).<\/span><\/a><\/div><div class=\"su-clear\"><\/div><\/div>\n<h3 class=\"p3\">Allergy<\/h3>\n<p class=\"p1\"><span class=\"s1\">The 3 most common allergies associated with pruritus in the dog are flea allergy, food allergy (sometimes called adverse food reactions), and atopy (or atopic dermatitis) (<\/span><strong><span class=\"s2\">TABLE 3<\/span><\/strong><span class=\"s1\">).<sup>1,9,10<\/sup> Dogs may be affected with 1 or more of these conditions or even all 3 concurrently. Dogs can also experience contact allergy, although less commonly than the other 3 allergy conditions. With the exception of flea allergy, workup of the other hypersensitivity disorders is more complex and involved than that of infectious and parasitic conditions. For this reason, an in-depth workup for allergy is often deferred until nonallergy causes of pruritus are identified and controlled or eliminated.<\/span><\/p>\n<p><a href=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Table3.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-23106\" src=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Table3.jpg\" alt=\"\" width=\"2180\" height=\"1078\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Table3.jpg 2180w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Table3-300x148.jpg 300w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Table3-1024x506.jpg 1024w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Table3-768x380.jpg 768w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Table3-1536x760.jpg 1536w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Table3-2048x1013.jpg 2048w\" sizes=\"(max-width: 2180px) 100vw, 2180px\" \/><\/a><\/p>\n<div class=\"su-custom-gallery su-custom-gallery-align-left su-custom-gallery-title-hover su-lightbox-gallery\"><div class=\"su-custom-gallery-slide\" style=\"width:192px;height:192px\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Fig5.jpg\" target=\"_blank\" title=\"Figure 5. Tailhead alopecia, hyperpigmentation, and scarring in a dog with chronic flea allergy dermatitis.\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Fig5.jpg\" alt=\"Figure 5. Tailhead alopecia, hyperpigmentation, and scarring in a dog with chronic flea allergy dermatitis.\" width=\"192\" height=\"192\" \/><span class=\"su-custom-gallery-title\">Figure 5. Tailhead alopecia, hyperpigmentation, and scarring in a dog with chronic flea allergy dermatitis.<\/span><\/a><\/div><div class=\"su-custom-gallery-slide\" style=\"width:192px;height:192px\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Fig6A.jpg\" target=\"_blank\" title=\"Figure 6A. Ventral interdigital (A) and axillary (B) erythema and alopecia in a food-allergic dog.\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Fig6A.jpg\" alt=\"Figure 6A. Ventral interdigital (A) and axillary (B) erythema and alopecia in a food-allergic dog.\" width=\"192\" height=\"192\" \/><span class=\"su-custom-gallery-title\">Figure 6A. Ventral interdigital (A) and axillary (B) erythema and alopecia in a food-allergic dog.<\/span><\/a><\/div><div class=\"su-custom-gallery-slide\" style=\"width:192px;height:192px\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Fig6B.jpg\" target=\"_blank\" title=\"Figure 6B. Ventral interdigital (A) and axillary (B) erythema and alopecia in a food-allergic dog.\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Fig6B.jpg\" alt=\"Figure 6B. Ventral interdigital (A) and axillary (B) erythema and alopecia in a food-allergic dog.\" width=\"192\" height=\"192\" \/><span class=\"su-custom-gallery-title\">Figure 6B. Ventral interdigital (A) and axillary (B) erythema and alopecia in a food-allergic dog.<\/span><\/a><\/div><div class=\"su-custom-gallery-slide\" style=\"width:192px;height:192px\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Fig7.jpg\" target=\"_blank\" title=\"Figure 7. Pinnal erythema and pyotraumatic dermatitis in a dog with food allergy and atopic dermatitis.\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Fig7.jpg\" alt=\"Figure 7. Pinnal erythema and pyotraumatic dermatitis in a dog with food allergy and atopic dermatitis.\" width=\"192\" height=\"192\" \/><span class=\"su-custom-gallery-title\">Figure 7. Pinnal erythema and pyotraumatic dermatitis in a dog with food allergy and atopic dermatitis.<\/span><\/a><\/div><div class=\"su-custom-gallery-slide\" style=\"width:192px;height:192px\"><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Fig8.jpg\" target=\"_blank\" title=\"Figure 8. Allergic otitis. Note the marked erythema even in the absence of significant signs of infection.\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Fig8.jpg\" alt=\"Figure 8. Allergic otitis. Note the marked erythema even in the absence of significant signs of infection.\" width=\"192\" height=\"192\" \/><span class=\"su-custom-gallery-title\">Figure 8. Allergic otitis. Note the marked erythema even in the absence of significant signs of infection.<\/span><\/a><\/div><div class=\"su-clear\"><\/div><\/div>\n<h2 class=\"p2\">Diagnostic Tools<\/h2>\n<h3 class=\"p3\">Initial Visit<\/h3>\n<ul>\n<li class=\"p5\"><b>Cytology:<\/b> The initial workup of the pruritic dog should include at least skin and\/or ear cytology.<\/li>\n<li class=\"p5\"><b>Skin scrapings:<\/b> The initial workup of the pruritic dog should also include skin scrapings of affected areas. Superficial skin scrapings may demonstrate many surface and superficial mites; deep skin scrapings may demonstrate <i>Demodex<\/i> mites.<\/li>\n<li class=\"p5\"><b>Flea combing and\/or surface tape impressions:<\/b> Examination of debris obtained by flea combing or with surface tape impressions may be helpful for demonstrating surface-dwelling mites, fleas, \u201cflea dirt,\u201d and lice.<\/li>\n<li class=\"p6\"><b>Flea control:<\/b> Aggressive flea control is an essential part of the workup and management of the pruritic dog. It is the author\u2019s opinion that a good-faith effort to institute a flea control trial program is worthwhile even in areas where fleas are considered uncommon.<sup>1<\/sup> This is particularly true given the potential effects of climate change and energy-efficient housing, which minimizes the effects of seasonal variations in temperature, humidity, etc., creating micro-environments that may be more conducive to flea survival.<sup>12<\/sup><\/li>\n<\/ul>\n<p class=\"p1\"><span class=\"s1\">Flea control should be included in the workup of the pruritic dog even when flea allergy is not considered to be a likely differential because fleas and their bites can produce irritation even in nonallergic patients. It is beyond the scope of this article to provide a detailed discussion of the available agents, but other resources are available.<sup>13<\/sup> The author particularly favors drugs in the isoxazoline class; however, in certain circumstances (e.g., patients with pre-existing neurologic disease or seizure history), these drugs should be used with caution, if at all. For these patients, other drugs (e.g., monthly indoxacarb or dinotefuran or weekly imidacloprid) may be sufficient.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">To ensure that flea control products are being used appropriately, question clients carefully about their current flea control measures. Ask specifically about the presence and treatment of other animals that may have contact with the patient. Also ask whether the dog has been exposed to situations in which fleas can be transmitted (e.g., dog parks, doggie day care). Free-roaming animals should be confined to a controlled space for the duration of the flea control trial. Measures should be taken to ensure that the dog and in-contact animals do not have access to open sheds, crawl spaces, etc., which may be reseeded with fleas by wildlife that might also access these areas.<sup>14<\/sup> In cases of heavy infestation (or if the clinical signs are particularly suggestive of flea allergy), treating the environment may be warranted. Indeed, many practitioners believe that environmental flea control is essential in geographic areas prone to heavy flea infestations (e.g., the southeastern U.S.). Environmental flea control measures may include frequent vacuuming of the area to which the dog has access and spraying the household with insect growth regulators (e.g., pyriproxyfen).<\/span><\/p>\n<h3 class=\"p3\">Other Diagnostics That May Be Useful<\/h3>\n<ul>\n<li class=\"p5\"><b>Wood\u2019s lamp examination, dermatophyte culture, dermatophyte polymerase chain reaction test, or careful examination of plucked hairs (trichogram):<\/b> Any of these procedures may be helpful if dermatophytosis is suspected.<\/li>\n<li class=\"p5\"><b>Culture and sensitivity testing:<\/b> For patients with a history of repeated antibiotic administration, deep pyoderma, or failure to respond to <a href=\"https:\/\/todaysveterinarypractice.com\/treating-canine-superficial-pyoderma-in-the-era-of-antimicrobial-resistance\/\">empirical antibiotic therapy<\/a>, consider bacterial culture and sensitivity testing.<\/li>\n<li class=\"p6\"><b>Biopsy:<\/b> For patients demonstrating little to no improvement despite appropriate antimicrobial and antiparasitic therapy, skin biopsy may be considered. A skin biopsy should not be performed in lieu of a good-faith effort to evaluate the patient for infectious, ectoparasitic, and (later) allergic disease. Although histology can demonstrate some infectious conditions (e.g., dermatophytosis, demodicosis), it is usually not the most efficient way to do so. Histology alone is unable to distinguish between many of the conditions described in this article.<sup>15<\/sup> Nonetheless, with these limitations in mind, a biopsy may be considered to provide further information and to help rule out more esoteric causes of pruritus, such as cutaneous lymphoma. The author typically reserves biopsies for patients that did not respond to appropriate therapy or patients with atypical presentations (e.g., persistent diffuse erythema or scale, ulceration, involvement of mucocutaneous junctions).<\/li>\n<\/ul>\n<h2 class=\"p2\">Diagnostic Approach<\/h2>\n<h3 class=\"p3\">1. Take a Thorough History<\/h3>\n<p class=\"p1\"><span class=\"s1\">For evaluating a pruritic dog, a thorough medical history is invaluable. A good history can help point the veterinarian toward likely diagnoses and, of equal importance, away from unlikely diagnoses. <\/span><strong><span class=\"s2\">TABLE 4<\/span><\/strong><span class=\"s1\"> shows questions to ask when taking a dermatologic history, some follow-up questions, and a brief synopsis of information to be gained from the answers.<\/span><\/p>\n<p><a href=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Table4-scaled-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-23107\" src=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Table4-scaled-1.jpg\" alt=\"\" width=\"2028\" height=\"2560\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Table4-scaled-1.jpg 2028w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Table4-scaled-1-238x300.jpg 238w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Table4-scaled-1-811x1024.jpg 811w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Table4-scaled-1-768x969.jpg 768w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Table4-scaled-1-1217x1536.jpg 1217w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2021\/04\/TVP_MayJune21_Pruritus_Table4-scaled-1-1622x2048.jpg 1622w\" sizes=\"(max-width: 2028px) 100vw, 2028px\" \/><\/a><\/p>\n<h3 class=\"p3\">2. Perform Physical and Dermatologic Examinations<\/h3>\n<p class=\"p1\"><span class=\"s1\">Every pruritic dog should undergo thorough physical and dermatologic examinations. It is beyond the scope of this article to cover all possible relevant findings; however, some areas are particularly important to evaluate. These areas are the dorsal and ventral interdigital skin, the claws and skin around the claw beds, the perianal and perineal skin, the elbow folds, and the ventral lip folds. In addition, a rectal exam is indicated for any patient with caudal pruritus since some patients with impacted anal sacs will lick or chew over the tailhead rather than scoot.<sup>19<\/sup> Evaluation of areas demonstrating erythema, pustules, bronzing (especially on the claws), or moist or greasy dermatitis may be particularly useful. <\/span><strong><span class=\"s2\">TABLES 1\u20133<\/span><\/strong><span class=\"s1\"> list some of the more common differential diagnoses, the typical distribution of these conditions, and relevant diagnostic techniques.<\/span><\/p>\n<h3 class=\"p3\">3. Identify and Eliminate Infectious and Ectoparasitic Causes First<\/h3>\n<p class=\"p1\"><span class=\"s1\">Although true that a significant percentage of pruritic dogs experience 1 or more types of allergic skin disease, it is often a better use of time to first evaluate the patient for infectious or parasitic causes of pruritus. With the exception of flea allergy (for which institution of aggressive flea control is always indicated), a workup for food allergy or atopic dermatitis may or may not be <\/span>indicated at the first examination.<span class=\"s1\"> If significant infection with fleas, bacteria, or yeast is found, elimination of these conditions may provide a <\/span>better baseline assessment of the patient\u2019s true condition.<\/p>\n<p class=\"p1\"><span class=\"s1\">Another reason to identify and eliminate infectious and ectoparasitic conditions first is because they are typically easier to identify and treat, whereas a thorough workup for allergic skin disease may be fairly expensive and lengthy. In addition, because pruritus can result from the combination of all factors present, failure to eliminate nonallergic conditions may interfere with an accurate assessment of the patient\u2019s condition, potentially skewing the results of an allergy workup.<sup>1<\/sup> Although the infectious and parasitic categories together represent a very large number of potential differential diagnoses, most of these conditions can be rapidly and inexpensively identified by using a relatively small number of diagnostic and therapeutic techniques (<\/span><strong><span class=\"s2\">TABLES 1, 2<\/span><\/strong><span class=\"s1\">). Should the pruritus persist after elimination of infections or parasites, an allergic skin disease workup would then be warranted.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">At the first visit, institution of some form of anti-inflammatory therapy is generally indicated. Pruritic behaviors create cutaneous microtrauma, which causes the release of inflammatory mediators and favors the development and perpetuation of infection. Although anti-inflammatory medications could interfere with assessment of the patient\u2019s condition in the short term, the decreased inflammation not only provides relief for the patient but also allows traumatized skin to heal and could facilitate elimination of secondary infections.<\/span><\/p>\n<h3 class=\"p3\">4. Treat and Reassess<\/h3>\n<p class=\"p1\"><span class=\"s1\">Reassessment is an important part of the workup of the pruritic dog. All too often, the veterinarian sees a patient months after the initial diagnostics and treatment were performed and prescribed, only to be told that the therapy \u201cdidn\u2019t work.\u201d Sometimes the patient did improve after initial therapy but started to worsen again after the initially prescribed medication ran out. If the client takes no action at this point, the condition will most likely continue to degrade, and by the time the client again seeks veterinary care, the brief respite from pruritus may be long forgotten. The author recommends that clients come in for a recheck or check in by phone or email 2 to 3 weeks after the initial visit. If necessary, the veterinarian or veterinary nurse can initiate contact. Patients should also be rechecked before medication is finished to confirm resolution of the infection\/infestation. If the patient has improved, it may then be possible to begin an allergic skin disease workup. If the patient has not improved sufficiently, workup may need to be delayed and the patient further evaluated (or re-evaluated) for the presence or recurrence of infectious or parasitic agents.<\/span><\/p>\n<h3 class=\"p3\">5. Perform Workup for Allergic Pruritic Skin Disease<\/h3>\n<p class=\"p7\"><strong>Flea Allergy<\/strong><\/p>\n<p class=\"p1\"><span class=\"s1\">As stated above, good flea control is important in the workup of any pruritic dog, regardless of whether flea allergy is considered to be a differential. Fortunately, modern flea control agents have made the elimination of fleas possible in all but the most challenging circumstances. Regardless of the agent(s) chosen, treatment of the patient and all in-contact animals must be maintained for a minimum of 12\u00a0weeks to be certain that the local flea population has been eliminated.<sup>1<\/sup><\/span><\/p>\n<p class=\"p7\"><strong>Food Allergy<\/strong><\/p>\n<p class=\"p1\"><span class=\"s1\">Many \u201cdiagnostic tools\u201d are marketed for the diagnosis of food allergy, including measurement of serum IgE, fecal IgE, or salivary food-specific IgE. Unfortunately, those modalities can neither reliably diagnose food allergy nor identify problematic or tolerated food items.<sup>20<\/sup> Patch testing and lymphocyte stimulation tests may be of some use but are typically restricted to investigational settings or academic institutions.<sup>21,22<\/sup> To date, the only practical method for the diagnosis of food allergy and identification of culprit foods is the <a href=\"https:\/\/todaysveterinarypractice.com\/performing-a-diet-trial-to-identify-food-allergies-in-dogs-and-cats\/\">dietary elimination trial<\/a>.<sup>20<\/sup><\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Elimination trials may be conducted by using either hydrolyzed diets (processed to minimize peptide size) or novel protein diets (commercial or home cooked). Both approaches are valid, but neither is guaranteed to succeed. If hydrolyzed protein diets are used for diagnostic purposes, ultrahydrolyzed diets (1- to 2-kilodalton fragments) are considered superior to semihydrolyzed diets (~10-kilodalton fragments).<sup>23<\/sup> The small peptide fragments in ultrahydrolyzed diets makes clinical reactivity unlikely (but still possible) even if the protein from which that diet is sourced is one that the patient has been fed before. If desired, an ultrahydrolyzed diet could be selected from a different protein source (e.g., salmon-based diet for a patient previously fed chicken). However, even this approach has its limitations since recent work has demonstrated that allergenic cross-reactivity is possible between surprisingly disparate sources, such as fish and chicken.<sup>24<\/sup><\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">If a novel protein diet is selected, the patient\u2019s dietary history should be reviewed to identify dietary items to which the patient has been exposed. Appropriate diets should consist of ingredients from sources phylogenetically distant from those in the patient\u2019s previous diet. For example, a kangaroo-based or alligator-based diet might be a good empirical choice for a dog previously fed chicken. Again, cross-reactivity remains a potential limitation of these diets as well.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Selecting the diet is only part of a dietary elimination trial. The client must also ensure that the dog does not receive food or food-based items from other sources, which may include foods eaten by other animals in the house, table scraps, dropped food, pill pockets, food-based chew toys (rawhides, hooves), and treats. Commonly overlooked food sources are chewable medications (including heartworm and flea preventives), animal feces, licking other animals\u2019 food bowls, and dirty dishes in the sink.<sup>1<\/sup><\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">There is no consensus on the required length of a diet trial. A recent review article recommended a minimum of 8 weeks to identify 95% of food-allergic patients; in a small number of dogs, food allergy was not identified until 13 weeks.<sup>25<\/sup> For at least the first few weeks of the trial, it may be prudent to provide anti-inflammatory\/antipruritic support (such as prednisolone). Doing so may be advisable not only for patient welfare but also because some evidence suggests that early suppression of cutaneous inflammation may shorten the necessary duration of the diet trial.<sup>26<\/sup> Ideally, all elimination diets should be followed by rechallenge with the dog\u2019s previous diet even if the dog does not become asymptomatic. Exacerbation of clinical disease after the challenge both confirms the diagnosis of food allergy in asymptomatic dogs and suggests a food allergy component in dogs demonstrating only partial improvement during the trial. Resolution of clinical flare after reinstitution of the elimination diet further solidifies the diagnosis.<\/span><\/p>\n<p class=\"p7\"><strong>Atopic Dermatitis<\/strong><\/p>\n<p class=\"p1\"><span class=\"s1\"><a href=\"https:\/\/todaysveterinarypractice.com\/canine-atopic-dermatitis-updates-diagnosis-treatment\/\">Atopic dermatitis<\/a> may be best thought of as a syndrome rather than a specific diagnosis. The condition is generally associated with hypersensitivity to environmental allergens. In addition, the additive nature of pruritus means that the presence of other irritating or allergic factors (e.g., infections, fleas, food allergy) can trigger clinical flares of atopic dermatitis.<sup>1,27<\/sup> This hypersensitivity may be IgE mediated, although for some patients that are otherwise identically affected, allergen-specific IgE cannot be demonstrated by serology or intradermal testing. These patients are referred to as having \u201catopic-like dermatitis.\u201d<sup>28<\/sup><\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Recently, 2 sets of criteria have been developed to help veterinarians diagnose atopic dermatitis (<\/span><strong><span class=\"s2\">BOX 1<\/span><\/strong><span class=\"s1\">).<sup>8<\/sup> By themselves, these criteria do not prove that a patient does or does not have atopic dermatitis, and they do not replace an appropriate workup to identify and eliminate other potential causes of atopic dermatitis. However, they do provide useful information about which clinical signs (and combination of signs) may best support a diagnosis of atopic dermatitis. Either set <\/span>of criteria may be used. The first set is relatively sensitive<span class=\"s1\"> and has moderate to high specificity; the second set is not sensitive but is highly to very highly specific.<\/span><\/p>\n<div class=\"su-box su-box-style-soft\" id=\"\" style=\"border-color:#003d45;border-radius:3px;\"><div class=\"su-box-title\" style=\"background-color:#007078;color:#ffffff;border-top-left-radius:1px;border-top-right-radius:1px\">BOX 1 Favrot\u2019s Criteria for Canine Atopic Dermatitis<sup>8<\/sup><\/div><div class=\"su-box-content su-u-clearfix su-u-trim\" style=\"border-bottom-left-radius:1px;border-bottom-right-radius:1px\"><strong>Set 1<\/strong><\/p>\n<ul>\n<li class=\"p1\"><span class=\"s1\">Age at onset &lt;3 years <\/span><\/li>\n<li class=\"p1\"><span class=\"s1\">Mostly indoor <\/span><\/li>\n<li class=\"p1\"><span class=\"s1\">Corticosteroid-responsive pruritus <\/span><\/li>\n<li class=\"p1\"><span class=\"s1\">Chronic or recurrent yeast infections <\/span><\/li>\n<li class=\"p1\"><span class=\"s1\">Affected front feet <\/span><\/li>\n<li class=\"p1\"><span class=\"s1\">Affected pinnae <\/span><\/li>\n<li class=\"p1\"><span class=\"s1\">Nonaffected ear margins <\/span><\/li>\n<li class=\"p1\"><span class=\"s1\">Nonaffected dorsolumbar area (if fleas have been eliminated) <\/span><\/li>\n<\/ul>\n<p class=\"p1\"><span class=\"s1\">Fulfillment of 5 of these criteria has high sensitivity (85.4%) and medium specificity (79.1%). <\/span><span class=\"s1\">Fulfillment of 6 of these criteria has low sensitivity (58.2%) and high specificity (88.5%). <\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><strong>Set 2<\/strong> <\/span><\/p>\n<ul>\n<li class=\"p1\"><span class=\"s1\">Age at onset &lt;3 <\/span><span class=\"s1\">years <\/span><\/li>\n<li class=\"p1\"><span class=\"s1\">Mostly indoor <\/span><\/li>\n<li class=\"p1\"><span class=\"s1\">\u201cAlesional\u201d pruritus at disease onset <\/span><\/li>\n<li class=\"p1\"><span class=\"s1\">Affected front feet <\/span><\/li>\n<li class=\"p1\"><span class=\"s1\">Affected pinnae <\/span><\/li>\n<li class=\"p1\"><span class=\"s1\">Nonaffected ear margins <\/span><\/li>\n<li class=\"p1\"><span class=\"s1\">Nonaffected dorsolumbar area (if fleas have been eliminated) <\/span><\/li>\n<\/ul>\n<p class=\"p1\"><span class=\"s1\">Fulfillment of 5 of these criteria has medium sensitivity (77.2%) and high specificity (83%). <\/span><span class=\"s1\">Fulfillment of 6 of these criteria has low sensitivity (42%) and very high specificity (93.7%).<\/span><\/p>\n<p><\/div><\/div>\n<p class=\"p1\"><span class=\"s1\">Because of the many potential contributing factors, it is prudent to ensure that all reasonable differentials are ruled out or (in the case of concurrent allergic skin disease) under control before the diagnosis of atopic dermatitis is made. For this reason, atopic dermatitis is considered to be a clinical diagnosis of exclusion. Although allergy testing (serology or intradermal) is often used to \u201cdiagnose\u201d atopic dermatitis, these diagnostics cannot reliably discriminate between healthy and atopic dogs and can only support a clinical diagnosis of atopy.<sup>29<\/sup><\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Although allergy testing alone cannot diagnose atopy, it is useful for identifying potential allergenic triggers so that desensitization can be attempted.<sup>1<\/sup> The preferred diagnostic test is generally intradermal testing because it mimics the interaction between the allergen and the patient. However, intradermal testing is not always possible or practical, in which case a good serologic test can provide useful information. Because variations in laboratory methods can significantly affect serologic assay results,<sup>30<\/sup> consulting a veterinary dermatologist before selecting a laboratory is recommended.<\/span><\/p>\n<h2 class=\"p2\">Conclusions<\/h2>\n<ul>\n<li class=\"p4\"><span class=\"s1\">The number of differential diagnoses for pruritus in dogs can seem overwhelming. However, following a few simple guidelines can greatly facilitate the workup.<\/span><\/li>\n<li class=\"p5\">Get a good history\u2014ask questions rather than assume that the client has told you everything of relevance.<\/li>\n<li class=\"p5\">First screen the patient for infectious or parasitic causes of pruritus before leaping into an allergic skin disease workup.<\/li>\n<li class=\"p5\">Treat and reassess\u2014evaluate the response to initial treatment to help avoid basing decisions on client memory (lapses) and to get a better idea of the patient\u2019s true baseline.<\/li>\n<li class=\"p6\">Leave atopic dermatitis for last. Unless the patient demonstrates purely seasonal pruritus, investigate infections, ectoparasitism, and food allergy first. Even patients with purely seasonal pruritus should be evaluated for the possible presence of seasonally influenced parasites, such as fleas and chiggers.<span class=\"Apple-converted-space\">\u00a0<\/span><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>A pruritic work-up should include getting a thorough history, eliminating infectious or parasitic causes before leaping into an allergic skin disease assessment, and leaving atopic dermatitis as a last-resort diagnosis.<\/p>\n","protected":false},"author":9,"featured_media":23103,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"iawp_total_views":3518,"footnotes":""},"categories":[322],"tags":[13],"class_list":["post-23164","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-may-june-2021","tag-peer-reviewed","column-features","column-insights-in-dermatology","clinical_topics-dermatology"],"acf":{"hide_sidebar":false,"hide_sidebar_ad":false,"hide_all_ads":false},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.7 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Diagnostic Approach to the Pruritic Dog | Today&#039;s Veterinary Practice<\/title>\n<meta name=\"description\" content=\"There are many differential diagnoses for pruritus in dogs, but following a few guidelines in the correct order can greatly 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