{"id":22148,"date":"2020-10-05T17:52:22","date_gmt":"2020-10-05T17:52:22","guid":{"rendered":"https:\/\/todaysveterinarypractice.com\/?p=22148"},"modified":"2022-04-05T15:32:04","modified_gmt":"2022-04-05T15:32:04","slug":"diet-trial-to-identify-food-allergies-in-dogs-and-cats","status":"publish","type":"post","link":"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/nutrition\/diet-trial-to-identify-food-allergies-in-dogs-and-cats\/","title":{"rendered":"Performing a Diet Trial to Identify Food Allergies in Dogs and Cats"},"content":{"rendered":"<p class=\"p1\"><span class=\"s1\">Adverse food reactions (AFRs) are immunologic (food allergy or hypersensitivity) or nonimmunologic (food intolerance) responses to dietary components. A <i>food allergy<\/i> is an aberrant adverse immune response elicited by exposure to a particular food substance;<sup>1<\/sup> most often, the culprit allergens are &lt;70 kDa glycoproteins.<sup>1<\/sup> A <i>food intolerance<\/i> can be a response to carbohydrates, dyes, flavors, and preservatives. <\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Diagnosis of an AFR goes hand in hand with treatment because confirmation of disease is based on response to therapy. Confirmation of an AFR depends on reduction or <\/span><span class=\"s2\">resolution of clinical signs while the animal is being fed a <\/span>strict elimination diet, recurrence of clinical<span class=\"s1\"> signs when the animal is challenged with the original diet (and anything else given orally), and resolution of signs after the elimination diet has been reinstated. <\/span><\/p>\n<h2 class=\"p2\">The Elimination\u2013Challenge Diet Trial<\/h2>\n<p class=\"p1\"><span class=\"s1\">A complete diagnostic elimination-challenge diet trial (ECDT) can be considered a 4-phase process\u2014eliminate, challenge, confirm, and identify\u2014and may last months. The length of each phase is determined by patient response to therapy and client compliance. The trial cannot move to a new phase until the previous phase has been successfully completed. A drawback is that some clients may not want to proceed to a new phase if their pet\u2019s condition has improved.<\/span><\/p>\n<h3 class=\"p3\">Phase 1: Eliminate<\/h3>\n<p class=\"p4\"><span class=\"s1\">This initial phase involves strictly feeding only the trial diet for up to 12 weeks while monitoring for reduction of clinical signs; no other treats, supplements, capsules, toothpastes, dental chews, outdoor hunting, or scavenging are allowed. Flavored oral medications should be transitioned to topical (e.g., parasite control). Ideally, the transition to the new diet should be gradual, over 5 to 7 days; however, some pets may tolerate a faster transition. Gastrointestinal signs usually improve within 2 to 3 weeks; cutaneous signs usually improve within 4 to 12 weeks.<sup>1<\/sup> Critical analysis of multiple studies showed that by 5 weeks (dogs) or 6\u00a0weeks (cats), cutaneous signs underwent remission for more than 80% of patients and by 8 weeks for more than 90%. To achieve complete remission, fewer than 5% of patients needed to continue phase 1 for longer than 13 weeks.<sup>2<\/sup><\/span><\/p>\n<ul>\n<li class=\"p5\">When phase 1 successfully alleviates clinical signs, some clients choose to not continue on to phase 2.<\/li>\n<li class=\"p6\">Phase 1 completion is determined by satisfactory reduction of clinical signs.<\/li>\n<\/ul>\n<p class=\"p1\"><span class=\"s1\"><b>Client communication note:<\/b> Emphasize that the only things that should enter the pet\u2019s mouth are the approved elimination diet and water. Off-leash parks and other free-range options may be problematic, so alternatives should be considered.<\/span><\/p>\n<h3 class=\"p3\">Phase 2: Challenge<\/h3>\n<p class=\"p4\"><span class=\"s1\">This phase involves reintroducing the previous diet while monitoring for recrudescence of signs. If the pet has an AFR, signs usually recur within 2 to 3 days but may take up to 2 weeks. <\/span><\/p>\n<ul>\n<li class=\"p5\">Ensure control of things that may cloud the clinical picture during future phases, such as secondary infection and appropriate parasite control.<\/li>\n<li class=\"p5\">If the ECDT is stopped during phase 2, an AFR will not be confirmed.<\/li>\n<li class=\"p6\">Phase 2 completion is determined by a flare of<br \/>\nclinical signs.<\/li>\n<\/ul>\n<p class=\"p1\"><span class=\"s1\"><b>Client communication note:<\/b> Remind clients to include other things the animal previously consumed, such as treats, supplements, and toothpastes. <\/span><\/p>\n<h3 class=\"p3\">Phase 3: Confirm<\/h3>\n<p class=\"p4\"><span class=\"s1\">This phase involves restarting the strict elimination diet; resolution of clinical signs confirms the diagnosis of an AFR. Confirmation may take 2 to 4 weeks while clients monitor for reduction of clinical signs. If the elimination diet is appropriate and balanced for the patient, it may be continued indefinitely. <\/span><\/p>\n<ul>\n<li class=\"p5\">Clients may choose to not pursue testing for individual allergens.<\/li>\n<li class=\"p5\">If the ECDT is stopped during phase 3, specific offending food allergens will not be confirmed.<\/li>\n<li class=\"p6\">Phase 3 completion is determined by resolution of clinical signs.<\/li>\n<\/ul>\n<p class=\"p1\"><span class=\"s1\"><b>Client communication note: <\/b>Advise clients that new allergies to this currently tolerated elimination diet may later arise and that not finishing the trial may require another ECDT in the future.<\/span><\/p>\n<h3 class=\"p3\">Phase 4: Identify<\/h3>\n<p class=\"p4\"><span class=\"s1\">This final phase of the ECDT is intended to identify the specific ingredients that cause a flare of signs and that should be avoided. The patient continues eating the strict elimination diet while being offered previously fed ingredients (usually proteins, which are the most commonly problematic) as treats or diet toppers. Small amounts (&lt;10% of caloric intake) of<br \/>\n1 ingredient at a time are offered for up to 2 weeks while the pet is monitored for recrudescence of signs. If no signs are noted, the ingredient can be fed; if signs are noted, the ingredient should be avoided. Although lack of response to a specific ingredient translates to tolerance of that ingredient, it does not rule out overall food intolerance. The only way to definitively diagnose a problem food is systematic testing of each ingredient.<\/span><\/p>\n<ul>\n<li class=\"p5\">Individual ingredients tested should be based on diet history and offending food or treats from phase 2. For example, if the challenge diet has 3 protein sources\u2014chicken, egg, and soy\u2014consider testing each one of these ingredients separately.<\/li>\n<li class=\"p5\">If a thorough diet history was undetermined (e.g.,\u00a0poor client recollection, new pet with unknown history), a starting point would be foods commonly reported to cause allergies in pets (<span class=\"s3\"><b>TABLE 1<\/b><\/span>).<\/li>\n<li class=\"p5\">Completing phase 4 helps determine problematic foods to avoid, which significantly improves prognosis. Knowing which ingredients are off-limits may enable clients to feed less expensive over-the-counter (OTC) diets in the future, although the potential for cross-contamination of these diets exists and may pose problems in sensitive individuals. In addition, if an allergy to the diet arises in the future, transitioning to another diet with previously tested and tolerated ingredients may avoid another lengthy ECDT.<\/li>\n<li class=\"p6\">Phase 4 completion depends on the client\u2019s willingness to test all potential allergens.<\/li>\n<\/ul>\n<p class=\"p1\"><span class=\"s1\"><b>Client communication note:<\/b> Set realistic expectations <\/span>together so that trials do not last an undetermined time.<a href=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/10\/TVP_NovDec20_FoodAllergyTrials_Table1-1.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"aligncenter size-full wp-image-30299\" src=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/10\/TVP_NovDec20_FoodAllergyTrials_Table1-1.jpg\" alt=\"\" width=\"2097\" height=\"693\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/10\/TVP_NovDec20_FoodAllergyTrials_Table1-1.jpg 2097w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/10\/TVP_NovDec20_FoodAllergyTrials_Table1-1-300x99.jpg 300w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/10\/TVP_NovDec20_FoodAllergyTrials_Table1-1-1024x338.jpg 1024w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/10\/TVP_NovDec20_FoodAllergyTrials_Table1-1-768x254.jpg 768w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/10\/TVP_NovDec20_FoodAllergyTrials_Table1-1-1536x508.jpg 1536w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/10\/TVP_NovDec20_FoodAllergyTrials_Table1-1-2048x677.jpg 2048w\" sizes=\"(max-width: 2097px) 100vw, 2097px\" \/><\/a><\/p>\n<h2 class=\"p2\">Elimination Diet Options<\/h2>\n<p class=\"p1\"><span class=\"s1\">Selecting an appropriate diet for a challenge trial depends on patient history. Hundreds of diet options are available at retail stores and online sources; however, an appropriate ECDT for diagnostic purposes should preferably be chosen from 3 broad categories: veterinary therapeutic limited-ingredient diets, veterinary therapeutic hydrolyzed-protein diets, or complete and balanced home-cooked diets. Many limited-ingredient OTC diets are available; however, studies have found some commercial products to be cross-contaminated with undeclared potential allergens.<sup>5,6<\/sup> Although these diets may be considered for long-term feeding, for the diagnostic purposes of an ECDT, OTC diets should be avoided because cross-contamination may result in failure to respond to an appropriate diet (<\/span><span class=\"s4\"><b>FIGURE 1<\/b><\/span><span class=\"s1\">).<\/span><\/p>\n<p class=\"p1\"><a href=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/10\/TVP_NovDec20_FoodAllergyTrials_Fig-1-1.jpg\"><img decoding=\"async\" class=\"aligncenter size-full wp-image-30298\" src=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/10\/TVP_NovDec20_FoodAllergyTrials_Fig-1-1.jpg\" alt=\"\" width=\"2069\" height=\"1202\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/10\/TVP_NovDec20_FoodAllergyTrials_Fig-1-1.jpg 2069w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/10\/TVP_NovDec20_FoodAllergyTrials_Fig-1-1-300x174.jpg 300w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/10\/TVP_NovDec20_FoodAllergyTrials_Fig-1-1-1024x595.jpg 1024w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/10\/TVP_NovDec20_FoodAllergyTrials_Fig-1-1-768x446.jpg 768w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/10\/TVP_NovDec20_FoodAllergyTrials_Fig-1-1-1536x892.jpg 1536w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/10\/TVP_NovDec20_FoodAllergyTrials_Fig-1-1-2048x1190.jpg 2048w\" sizes=\"(max-width: 2069px) 100vw, 2069px\" \/><\/a><\/p>\n<h3 class=\"p3\">Veterinary Therapeutic Limited-Ingredient Diets<\/h3>\n<p class=\"p1\"><span class=\"s1\">These diets, also called novel protein diets, are formulated for adult maintenance and typically offer uncommon protein sources. The strategy is to feed something to which the pet has not been previously exposed to. Unfortunately, many OTC diets now include previously uncommon ingredients, which makes finding a novel protein difficult. Ingredients such as rabbit, venison, fish, duck, and kangaroo are now present not only in veterinary therapeutic diets but often in OTC diets and treats as well. When choosing a novel protein as part of the diagnostic process, a thorough diet history is necessary to determine which protein source is novel.<\/span><\/p>\n<p class=\"p4\"><span class=\"s1\"><b>Benefits include<\/b><\/span><\/p>\n<ul>\n<li class=\"p5\">Complete and balanced nutrition<\/li>\n<li class=\"p5\">Palatability<\/li>\n<li class=\"p5\">Appropriateness for long-term feeding<\/li>\n<li class=\"p6\">Moderate cost<\/li>\n<\/ul>\n<p class=\"p4\"><span class=\"s1\"><b>Drawbacks include<\/b><\/span><\/p>\n<ul>\n<li class=\"p5\">Requirement for thorough diet history (Pet may have already been exposed to the ingredient through cross-contamination of an OTC brand.)<\/li>\n<li class=\"p5\">Limited options for growing pets<\/li>\n<li class=\"p5\">Increased nutrients to benefit skin health (fatty acids) in some diets (This may cloud results. Positive response may not be solely attributed to food allergy if a full ECDT is not performed to confirm an AFR.)<\/li>\n<\/ul>\n<h3 class=\"p3\">Veterinary Therapeutic Hydrolyzed-Protein Diets<\/h3>\n<p class=\"p1\"><span class=\"s1\">Hydrolyzed-protein diets have been processed to provide small peptides or amino acids rather than intact proteins and large polypeptides. The strategy is to provide the proteins in small peptides, typically &lt;13\u00a0kDa, to avoid detection by the immune system and consequent reactions. Currently available hydrolyzed protein sources include chicken, chicken liver, soy, salmon, and feathers.<\/span><\/p>\n<p class=\"p4\"><span class=\"s1\"><b>Benefits include<\/b><\/span><\/p>\n<ul>\n<li class=\"p5\">Complete and balanced nutrition<\/li>\n<li class=\"p5\">High digestibility<\/li>\n<li class=\"p5\">Diagnostic utility when diet history is limited<\/li>\n<li class=\"p5\">Appropriateness for long-term feeding<\/li>\n<li class=\"p5\">Reasonable palatability<\/li>\n<li class=\"p6\">Adult maintenance formulations (One diet that has undergone feeding trials in puppies is appropriate for growth.)<\/li>\n<\/ul>\n<p class=\"p4\"><span class=\"s1\"><b>Drawbacks include<\/b><\/span><\/p>\n<ul>\n<li class=\"p5\">Higher cost (particularly for large breed dogs)<\/li>\n<li class=\"p5\">Variable palatability<\/li>\n<li class=\"p5\">Retained allergenicity; reactions still possible<\/li>\n<\/ul>\n<h2>Home-Cooked Diets with Novel Ingredients<\/h2>\n<p class=\"p1\"><span class=\"s1\"><a href=\"https:\/\/todaysveterinarypractice.com\/evaluating-fresh-diets-in-practice\/\">Home-cooked diets<\/a> are made with whole food (\u201chuman food\u201d) and are usually formulated with a limited number of novel ingredients. Preferably, 1 novel protein and 1 novel carbohydrate source are included to minimize antigen exposure and identify tolerated ingredients. Unless formulated by a veterinary nutritionist, home-cooked diets will likely be incomplete and unbalanced. Studies of dogs and cats have shown that even home-cooked maintenance diets made from recipes found online and in books, written by veterinarians and laypersons, were unbalanced. Approximately 95% of recipes for dogs<sup>7<\/sup> and 100% of recipes for cats<sup>8<\/sup> evaluated had at least 1, but usually many more, essential nutrients below minimum requirements. Although some ECDTs are performed by using unbalanced home-cooked diets, doing so is not recommended; many nutrients are essential for skin and gastrointestinal health, and clients may choose to continue the tolerated but unbalanced diet for the long term, which may lead to problems such as nutrient deficiencies, toxicities, and other adverse health effects.<\/span><\/p>\n<p class=\"p4\"><span class=\"s1\"><b>Benefits include<\/b><\/span><\/p>\n<ul>\n<li class=\"p5\">Complete and balanced nutrition if formulated by a board-certified veterinary nutritionist or someone with a PhD in canine and feline nutrition<\/li>\n<li class=\"p5\">Excellent palatability, often highly digestible<\/li>\n<li class=\"p5\">Ability to be individualized for pet\u2019s needs<\/li>\n<li class=\"p5\">Limited number of potential allergens<\/li>\n<li class=\"p6\">Client participation, which strengthens the human-animal bond<\/li>\n<\/ul>\n<p class=\"p4\"><span class=\"s1\"><b>Drawbacks include<\/b><\/span><\/p>\n<ul>\n<li class=\"p5\">Unbalanced nutrition if not properly formulated<\/li>\n<li class=\"p5\">Can be expensive (particularly for large breed dogs)<sup>9<\/sup><\/li>\n<li class=\"p5\">Time-consuming, often inconvenient (preparation, storage of ingredients and prepared diet)<\/li>\n<li class=\"p5\">Probable drift away from home-cooked diet recipe,<sup>10<\/sup> which could unbalance even a properly formulated diet (switching ingredients, amounts, and\/or cooking methods can unbalance a diet)<\/li>\n<\/ul>\n<h2 class=\"p2\">Long-Term Management<\/h2>\n<p class=\"p1\"><span class=\"s1\">After an AFR has been diagnosed as the cause for clinical signs, long-term management involves avoiding problematic foods. No further diagnostics or rechecks are necessary, although future flares may require rechecks and potential transition to another diet or management of other allergic\/seasonal disease. Transitioning to an OTC diet may be considered, with the understanding that potential cross-contamination may cause problems for some sensitive individuals. When clients can properly manage the patient\u2019s diet, the prognosis for an AFR is excellent. <\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Confirmation of an adverse food reaction depends on reduction or resolution of clinical signs while the animal is being fed a strict elimination diet, recurrence of clinical signs when the animal&#8217;s diet is challenged, and resolution of signs after the elimination diet has been reinstated.<\/p>\n","protected":false},"author":9,"featured_media":22129,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"iawp_total_views":5238,"footnotes":""},"categories":[330],"tags":[13],"class_list":["post-22148","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-november-december-2020","tag-peer-reviewed","column-nutrition-notes","clinical_topics-nutrition"],"acf":{"hide_sidebar":false,"hide_sidebar_ad":false,"hide_all_ads":false},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.7 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Performing a Diet Trial to Identify Food Allergies in Dogs and Cats | Today&#039;s Veterinary Practice<\/title>\n<meta name=\"description\" content=\"A complete diagnostic elimination\u2013challenge diet trial isolates the cause of adverse food reactions through 4 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