{"id":21593,"date":"2020-08-11T19:55:24","date_gmt":"2020-08-11T19:55:24","guid":{"rendered":"https:\/\/todaysveterinarypractice.com\/?p=21593"},"modified":"2022-04-05T18:10:28","modified_gmt":"2022-04-05T18:10:28","slug":"ultrasound-guided-fine-needle-aspiration-and-core-biopsy","status":"publish","type":"post","link":"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/diagnostics\/ultrasound-guided-fine-needle-aspiration-and-core-biopsy\/","title":{"rendered":"Ultrasound-Guided Fine Needle Aspiration and Core Biopsy"},"content":{"rendered":"<p class=\"p1\"><span class=\"s1\">Ultrasound examination is an excellent diagnostic tool for detecting visceral abnormalities in small animals. Many ultrasound findings, however, can be nonspecific. Although masses, nodules, effusions, and other <\/span><span class=\"s2\">macromorphologic abnormalities can be readily identified,<\/span><span class=\"s1\"> tissue samples are often necessary for a more definitive diagnosis. Ultrasound-guided fine needle aspiration (FNA) and core biopsy are safe, minimally invasive techniques that can help obtain an etiologic diagnosis.<sup>1<\/sup><\/span><\/p>\n<h2 class=\"p2\">Indications for Ultrasound-Guided Sampling<\/h2>\n<p class=\"p1\"><span class=\"s1\">Percutaneous ultrasound-guided FNA and biopsy procedures are routinely employed in small animal medicine to determine if a lesion represents inflammation, infection, or neoplasia. They are also performed when laboratory abnormalities suggest an underlying disease and when staging is desired for neoplastic disease. <\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Many locations and types of lesions can be sampled using ultrasound guidance (<\/span><span class=\"s3\"><b>BOX 1<\/b><\/span><span class=\"s1\">). Abdominocentesis, pleurocentesis, and pericardiocentesis are also commonly performed with ultrasound guidance. In addition, ultrasound can identify and guide needles into lesions along bone surfaces.<sup>3,4<\/sup> Samples obtained from these sites can be submitted for fluid, cytologic, culture, and\/or biochemical analysis.<\/span><\/p>\n<div class=\"su-box su-box-style-default .content-box-blue { background-color: #F0F8FF; border-left: 8px solid #CEE1EF; font-size: 18px; }\" id=\"\" style=\"border-color:#003d45;border-radius:3px;\"><div class=\"su-box-title\" style=\"background-color:#007078;color:#ffffff;border-top-left-radius:1px;border-top-right-radius:1px\">BOX 1 Locations Suitable for Ultrasound-Guided Needle Sampling<\/div><div class=\"su-box-content su-u-clearfix su-u-trim\" style=\"border-bottom-left-radius:1px;border-bottom-right-radius:1px\"><span class=\"s1\"><strong>Transabdominal ultrasound\u00b2<\/strong><\/span><\/p>\n<ul>\n<li class=\"p1\"><span class=\"s1\">Liver <\/span><\/li>\n<li class=\"p1\"><span class=\"s1\">Gallbladder <\/span><\/li>\n<li class=\"p1\"><span class=\"s1\">Spleen <\/span><\/li>\n<li class=\"p1\"><span class=\"s1\">Gastrointestinal tract <\/span><\/li>\n<li class=\"p1\"><span class=\"s1\">Adrenal glands <\/span><\/li>\n<li class=\"p1\"><span class=\"s1\">Pancreas <\/span><\/li>\n<li class=\"p1\"><span class=\"s1\">Prostate gland <\/span><\/li>\n<li class=\"p1\"><span class=\"s1\">Bladder <\/span><\/li>\n<li class=\"p1\"><span class=\"s1\">Kidneys <\/span><\/li>\n<li class=\"p1\"><span class=\"s1\">Ovaries <\/span><\/li>\n<li class=\"p1\"><span class=\"s1\">Uterus <\/span><\/li>\n<li class=\"p1\"><span class=\"s1\">Intra-abdominal lymph nodes <\/span><\/li>\n<li class=\"p1\"><span class=\"s1\">Mesenteric masses <\/span><\/li>\n<li class=\"p1\"><span class=\"s1\">Abdominal ascitic fluid, cysts, and abscesses <\/span><\/li>\n<\/ul>\n<p class=\"p1\"><span class=\"s1\"><strong>Cervical ultrasound<\/strong> <\/span><\/p>\n<ul>\n<li class=\"p1\"><span class=\"s1\">Thyroid and parathyroid glands <\/span><\/li>\n<li class=\"p1\"><span class=\"s1\">Regional lymph nodes <\/span><\/li>\n<\/ul>\n<p class=\"p1\"><span class=\"s1\"><strong>Noncardiac thoracic ultrasound<\/strong> <\/span><\/p>\n<ul>\n<li class=\"p1\"><span class=\"s1\">Lungs <\/span><\/li>\n<li class=\"p1\"><span class=\"s1\">Mediastinum <\/span><\/li>\n<li class=\"p1\"><span class=\"s1\">Pleural and thoracic wall lesions<\/span><\/li>\n<\/ul>\n<p><\/div><\/div>\n<h2 class=\"p2\">Potential Challenges of Ultrasound-Guided Sampling<\/h2>\n<p class=\"p1\"><span class=\"s1\">Ultrasound-guided biopsy may not be possible where gas or bone prevents access to the lesion. Repositioning the patient or changing the transducer position may create a better window. Otherwise, computed tomography, fluoroscopy, or open surgical sampling may be necessary. Structures and lesions located deep in the pelvic canal may not be accessible by a transabdominal approach. In cases that involve the prostate, bladder, and distal urethra, ultrasound guidance can still be used to obtain samples via traumatic urethral catheterization.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">While some larger gastrointestinal masses may be amenable to ultrasound-guided biopsy, smaller lesions may be harder to access and exfoliate, especially if penetration of the gastrointestinal lumen is to be avoided. Laparoscopic or surgical biopsy is indicated for these cases.<\/span><\/p>\n<h2 class=\"p2\">Advantages of Ultrasound-Guided Sampling<\/h2>\n<p class=\"p1\"><span class=\"s1\">The advantages to performing ultrasound-guided needle sampling\u2014either FNA or core biopsy\u2014are numerous. It is a safe, minimally invasive, rapid technique that is relatively inexpensive compared with more invasive diagnostic procedures, and there is no radiation exposure.<sup>5<\/sup> No other imaging-guided technique allows the same precise, real-time observation of the sampling device and immediate postprocedure monitoring. Ultrasound guidance enables avoidance of low diagnostic yield regions, such as central tumor necrosis, and high-risk regions, such as blood vessels and the renal medulla. The information gained from ultrasound-guided needle sampling can help with patient prognosis, surgical planning, chemotherapy options, and radiation treatment. It may also eliminate the need for surgery.<\/span><\/p>\n<h2 class=\"p2\">Potential Complications of Ultrasound-Guided Sampling<\/h2>\n<p class=\"p1\"><span class=\"s1\">The risk for complications of ultrasound-guided biopsy is influenced by the sonographer\u2019s training and experience, the needle size, the tissue being sampled, and the location of the lesion. The most common complication associated with ultrasound-guided needle procedures is hemorrhage (<\/span><span class=\"s3\"><b>TABLE 1<\/b><\/span><span class=\"s1\">). In most cases, bleeding is minimal and self-limiting.<\/span><\/p>\n<p><a href=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/08\/TVP_2020_0910_Ultrasound-Guided-Biopsy_Table-1.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"aligncenter size-full wp-image-21599\" src=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/08\/TVP_2020_0910_Ultrasound-Guided-Biopsy_Table-1.jpg\" alt=\"\" width=\"1008\" height=\"639\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/08\/TVP_2020_0910_Ultrasound-Guided-Biopsy_Table-1.jpg 1008w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/08\/TVP_2020_0910_Ultrasound-Guided-Biopsy_Table-1-300x190.jpg 300w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/08\/TVP_2020_0910_Ultrasound-Guided-Biopsy_Table-1-768x487.jpg 768w\" sizes=\"(max-width: 1008px) 100vw, 1008px\" \/><\/a><\/p>\n<p class=\"p1\"><span class=\"s1\">The risk for pneumothorax exists when aspirations or biopsies on the thoracic cavity are performed or when a high paracostal approach to the liver is used.<sup>6<\/sup><b> <\/b>When pneumothorax does occur, it is usually small and self-limiting.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Although seeding of neoplastic cells along the needle track has been reported with certain cancers (<\/span><span class=\"s3\"><b>TABLE 1<\/b><\/span><span class=\"s1\">), it is rare. In these cases, the benefit versus risk must be <\/span>considered. Bladder and prostatic tumors can be sampled by ultrasound-guided traumatic urethral catheterization, which eliminates the risk of abdominal seeding.<\/p>\n<p class=\"p1\"><span class=\"s1\">Fatal shock reactions have been associated with the use of fully automatic biopsy needles in cats. This is presumably due to the pressure wave and subsequent vagotonia created by firing the device.<sup>8<\/sup> Semi-automatic or manual core biopsy devices can be employed instead. Care must be exercised when FNA is performed on the adrenal glands owing to their high vascularity and the risk of triggering a hypertensive crisis if a pheochromocytoma is present. Referral for surgical biopsy may be preferable.<\/span><\/p>\n<h2 class=\"p2\">Fine Needle Aspiration Versus Core Biopsy<\/h2>\n<p class=\"p1\"><span class=\"s1\">In deciding whether to perform FNA or core biopsy, factors such as the size, suspected type, vascularity, and location of the abnormality must be considered, along with the risk to the patient.<sup>9<\/sup> <\/span><span class=\"s3\"><b>TABLE 2<\/b><\/span><span class=\"s1\"> provides general guidelines to help decide when to use FNA versus core biopsy for tissue sampling. If a patient has a coagulopathy or is unstable for sedation, or if the operator is unable to obtain access to the sampling site without penetrating other organs, neither core biopsy nor FNA may be suitable.<\/span><\/p>\n<p class=\"p1\"><a href=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/08\/TVP_2020_0910_Ultrasound-Guided-Biopsy_Table-2.jpg\"><img decoding=\"async\" class=\"aligncenter wp-image-21600\" src=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/08\/TVP_2020_0910_Ultrasound-Guided-Biopsy_Table-2.jpg\" alt=\"\" width=\"350\" height=\"207\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/08\/TVP_2020_0910_Ultrasound-Guided-Biopsy_Table-2.jpg 1080w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/08\/TVP_2020_0910_Ultrasound-Guided-Biopsy_Table-2-300x177.jpg 300w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/08\/TVP_2020_0910_Ultrasound-Guided-Biopsy_Table-2-1024x605.jpg 1024w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/08\/TVP_2020_0910_Ultrasound-Guided-Biopsy_Table-2-768x454.jpg 768w\" sizes=\"(max-width: 350px) 100vw, 350px\" \/><\/a><\/p>\n<h3 class=\"p3\">Fine Needle Aspiration<\/h3>\n<p class=\"p1\"><span class=\"s1\">One advantage of FNA over core biopsy is that it usually requires very little to no sedation.<sup>1<\/sup> However, ultrasound-guided FNA samples are smaller than core biopsy samples. As such, the cytologic results may be nonspecific or may not correlate with the final histopathologic diagnosis.<sup>10,11<\/sup> This is a common problem with some liver and spleen aspirates where core, laparoscopic, or surgical biopsy may be a better choice depending on the lesion location and clinical presentation. <\/span><\/p>\n<h3 class=\"p3\">Core Biopsy<\/h3>\n<p class=\"p1\"><span class=\"s1\">Core biopsy needles are easier to visualize on ultrasound imaging than the needles used for FNA and provide superior samples; however, they are associated with a higher rate of complications such as hemorrhage.<sup>5,12<\/sup> Smaller-gauge core biopsy needles can be used to lower the risk of hemorrhage, although this may also lower sample quality owing to smaller size, tissue crushing, and tissue fragmentation.<sup>13<\/sup> Sometimes even core biopsy samples are too small for a definitive diagnosis. In these cases, laparoscopic or surgical biopsy is indicated. <\/span><\/p>\n<h2 class=\"p2\">Ultrasound-Guided Sampling Procedures<\/h2>\n<h3 class=\"p3\">Equipment<\/h3>\n<p class=\"p1\"><span class=\"s1\">When FNA is being performed, a 22-gauge by 1\u00bd-inch needle is adequate to obtain cytologic samples for most lesions; however, deeper lesions may require longer spinal needles. The stylet used with spinal needles decreases the chance of collecting nondiagnostic tissue (e.g., abdominal fat) during placement (<\/span><span class=\"s3\"><b>FIGURE 1<\/b><\/span><span class=\"s1\">). The stylet is left in place until the lesion is reached. Lesions that are prone to blood contamination can be sampled with smaller, 25-gauge needles.<\/span><\/p>\n<div id=\"attachment_21594\" style=\"width: 410px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/08\/TVP_2020_0910_Ultrasound-Guided-Biopsy_Fig-1.jpg\"><img decoding=\"async\" aria-describedby=\"caption-attachment-21594\" class=\" wp-image-21594\" src=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/08\/TVP_2020_0910_Ultrasound-Guided-Biopsy_Fig-1.jpg\" alt=\"\" width=\"400\" height=\"300\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/08\/TVP_2020_0910_Ultrasound-Guided-Biopsy_Fig-1.jpg 792w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/08\/TVP_2020_0910_Ultrasound-Guided-Biopsy_Fig-1-300x225.jpg 300w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/08\/TVP_2020_0910_Ultrasound-Guided-Biopsy_Fig-1-768x576.jpg 768w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><\/a><p id=\"caption-attachment-21594\" class=\"wp-caption-text\">Figure 1. Supplies for ultrasound-guided fine needle aspiration, from left: sterile syringe, 1\u00bd-inch 22- and 25-gauge hypodermic needles, sample collection tubes, slides, culturette, and spinal needle.<\/p><\/div>\n<p class=\"p1\"><span class=\"s1\">Core biopsy needles range in size from 14- to 18-gauge and vary in length. Both automatic and semiautomatic core biopsy systems are available (<\/span><span class=\"s3\"><b>FIGURE 2<\/b><\/span><span class=\"s1\">). Automatic systems may be more economical and precise, but because they eject the needle tip beyond the needle placement point, they require adequate evaluation of the depth of the lesion. Fully automatic biopsy needles may best be avoided in cats based on the potential for fatal shock reactions.<sup>8<\/sup> The advantage of semiautomatic systems is they do not eject the cutting core beyond the needle point visualized in the lesion. This may help prevent inadvertent penetration of surrounding tissues (<\/span><span class=\"s3\"><b>FIGURE 3<\/b><\/span><span class=\"s1\">).<\/span><\/p>\n<div id=\"attachment_21595\" style=\"width: 410px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/08\/TVP_2020_0910_Ultrasound-Guided-Biopsy_Fig-2.jpg\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-21595\" class=\" wp-image-21595\" src=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/08\/TVP_2020_0910_Ultrasound-Guided-Biopsy_Fig-2.jpg\" alt=\"\" width=\"400\" height=\"300\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/08\/TVP_2020_0910_Ultrasound-Guided-Biopsy_Fig-2.jpg 792w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/08\/TVP_2020_0910_Ultrasound-Guided-Biopsy_Fig-2-300x225.jpg 300w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/08\/TVP_2020_0910_Ultrasound-Guided-Biopsy_Fig-2-768x576.jpg 768w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><\/a><p id=\"caption-attachment-21595\" class=\"wp-caption-text\">Figure 2. Two fully automatic core biopsy needles (left) and two semiautomatic core biopsy needles (right).<\/p><\/div>\n<div id=\"attachment_21596\" style=\"width: 410px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/08\/TVP_2020_0910_Ultrasound-Guided-Biopsy_Fig-3.jpg\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-21596\" class=\" wp-image-21596\" src=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/08\/TVP_2020_0910_Ultrasound-Guided-Biopsy_Fig-3.jpg\" alt=\"\" width=\"400\" height=\"315\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/08\/TVP_2020_0910_Ultrasound-Guided-Biopsy_Fig-3.jpg 936w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/08\/TVP_2020_0910_Ultrasound-Guided-Biopsy_Fig-3-300x237.jpg 300w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/08\/TVP_2020_0910_Ultrasound-Guided-Biopsy_Fig-3-768x606.jpg 768w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><\/a><p id=\"caption-attachment-21596\" class=\"wp-caption-text\">Figure 3. Ultrasound image of a Tru-Cut core biopsy needle taking a sample from a mediastinal mass. The arrows point to the needle sample notch.<\/p><\/div>\n<h3 class=\"p3\">Patient Preparation<\/h3>\n<p class=\"p1\"><span class=\"s1\">Preparation of the patient for ultrasound-guided <\/span>sampling should include a minimum database of packed cell volume, total solids, platelet count, and coagulation <span class=\"s1\">profile.<sup>14<\/sup> A coagulation profile is optional for FNA procedures but is recommended for patients with signs of coagulopathy or that are systemically ill.<sup>2,15<\/sup><i> <\/i>Some patients undergoing ultrasound-guided FNA may not require sedation; however, nervous, uncooperative patients or those with lesions that are difficult to reach should be sedated to minimize adverse events. Patients undergoing ultrasound-guided core biopsies should always be heavily sedated or completely anesthetized to eliminate movement during the procedure. Patient <\/span>fasting is indicated to limit complications associated with aspiration during sedation.<\/p>\n<p class=\"p1\"><span class=\"s1\">Depending on the organ to be sampled, the patient is placed in either dorsal or lateral recumbency. Patients undergoing sampling of thoracic lesions are positioned in lateral recumbency and examined from the nondependent side.<sup>16<\/sup> The surrounding area is clipped and ultrasound gel is removed to prevent artifact in cytologic samples. A sterile preparation of the skin is recommended for core biopsy, but alcohol preparation is often adequate for FNA.<\/span><\/p>\n<h3 class=\"p3\">Sample Collection<\/h3>\n<p class=\"p1\"><span class=\"s1\">The ultrasound probe may be covered with a sterile sleeve or glove to maintain the sterile field, and sterile jelly can be used for acoustic coupling.<sup>2,16<\/sup><b><i> <\/i><\/b>Alternatively, a sterile field may be maintained by preventing the probe from contacting the needle\u2019s point of entrance.<i> <\/i><\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Many ultrasound machines come with software that accommodates the use of a biopsy guide that indicates the needle\u2019s path during the biopsy. The disadvantage of these guides is that they offer little flexibility in adjusting the path of the needle. A freehand needle placement technique can be used instead and is the same for FNA and needle core biopsy. In this technique, the needle is positioned cranial or caudal to the probe and lined up exactly with the probe marker in a sagittal plane in order to be seen within the ultrasound beam (<\/span><span class=\"s3\"><b>FIGURE 4<\/b><\/span><span class=\"s1\">). Care must be taken to avoid needle insertion into the probe. The angle of the needle varies according to the depth of the lesion, with deeper lesions requiring more acute angles to the probe. Mastering this technique may be achieved through practice on a phantom model.<sup>17<\/sup><\/span><\/p>\n<div id=\"attachment_21597\" style=\"width: 360px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/08\/TVP_2020_0910_Ultrasound-Guided-Biopsy_Fig-4.jpg\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-21597\" class=\" wp-image-21597\" src=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/08\/TVP_2020_0910_Ultrasound-Guided-Biopsy_Fig-4.jpg\" alt=\"\" width=\"350\" height=\"467\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/08\/TVP_2020_0910_Ultrasound-Guided-Biopsy_Fig-4.jpg 621w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/08\/TVP_2020_0910_Ultrasound-Guided-Biopsy_Fig-4-225x300.jpg 225w\" sizes=\"(max-width: 350px) 100vw, 350px\" \/><\/a><p id=\"caption-attachment-21597\" class=\"wp-caption-text\">Figure 4. Ultrasound-guided fine needle aspiration demonstrating correct needle positioning with the needle lined up exactly with the probe marker in a sagittal plane.<\/p><\/div>\n<p class=\"p4\"><b>Core Biopsy<\/b><\/p>\n<p class=\"p1\"><span class=\"s1\">For core biopsy, a small skin incision is needed to facilitate needle passage. Once the needle is positioned in the lesion, the trigger is released and the needle removed. The core sample can then be gently teased from the needle and placed in formalin for histologic assessment (<\/span><span class=\"s3\"><b>FIGURE 5<\/b><\/span><span class=\"s1\">).<\/span><\/p>\n<div id=\"attachment_21598\" style=\"width: 360px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/08\/TVP_2020_0910_Ultrasound-Guided-Biopsy_Fig-5.jpg\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-21598\" class=\" wp-image-21598\" src=\"https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/08\/TVP_2020_0910_Ultrasound-Guided-Biopsy_Fig-5.jpg\" alt=\"\" width=\"350\" height=\"467\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/08\/TVP_2020_0910_Ultrasound-Guided-Biopsy_Fig-5.jpg 621w, https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2020\/08\/TVP_2020_0910_Ultrasound-Guided-Biopsy_Fig-5-225x300.jpg 225w\" sizes=\"(max-width: 350px) 100vw, 350px\" \/><\/a><p id=\"caption-attachment-21598\" class=\"wp-caption-text\">Figure 5. Semiautomatic core biopsy needle with a tissue sample present in the sampling notch. Core samples to be submitted in formalin for histopathology are displayed.<\/p><\/div>\n<p class=\"p4\"><b>Fine Needle Aspiration<\/b><\/p>\n<p class=\"p1\"><span class=\"s1\">For FNA, the needle is attached to a 6-mL syringe containing 1 to 2 mL of air that will aid in expelling the sample onto a glass slide. For solid lesions, a rapid, pecking technique is used to collect cells from the lesion. For liquid or cystic lesions, the needle may be attached to an extension set that is then attached to a needle of appropriate size for aspiration. Fluid collected from such lesions can be prepared for cytologic assessment and\/or submitted for culture and sensitivity testing. Slides are prepared for cytology in standard fashion.<\/span><\/p>\n<h3 class=\"p3\">Postprocedure Monitoring<\/h3>\n<p class=\"p1\"><span class=\"s1\">The patient should be monitored for complications post-biopsy. Hospitalization for 4 to 6 hours is recommended after needle core biopsy owing to the greater potential for bleeding. The abdomen or thorax can be scanned for fluid accumulation and the patient monitored for breathing difficulty that may occur with pneumothorax. Packed cell volume and total solids measurement can be repeated 4 to 5 hours after biopsy to monitor for blood loss, which would warrant a repeat scan.<sup>15<\/sup> <\/span><\/p>\n<h2 class=\"p2\">Conclusion<\/h2>\n<p class=\"p1\"><span class=\"s1\">Ultrasound-guided FNA and needle core biopsy are excellent techniques for obtaining diagnostic tissue samples. The procedures are relatively safe, low cost, minimally invasive, and frequently necessary for obtaining a definitive diagnosis and making an appropriate diagnostic and treatment plan. While complications are possible, they are usually minimal, especially when the procedure is performed by a highly trained and experienced veterinary sonographer. <\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ultrasound-guided sampling techniques are relatively safe, low cost, minimally invasive techniques for obtaining diagnostic tissue samples.<\/p>\n","protected":false},"author":9,"featured_media":21491,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"iawp_total_views":6635,"footnotes":""},"categories":[329],"tags":[13],"class_list":["post-21593","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-september-october-2020","tag-peer-reviewed","column-management-strategies","clinical_topics-diagnostics","clinical_topics-radiology-imaging"],"acf":{"hide_sidebar":false,"hide_sidebar_ad":false,"hide_all_ads":false},"yoast_head":"<!-- This site is optimized 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