{"id":18529,"date":"2019-09-09T10:04:02","date_gmt":"2019-09-09T10:04:02","guid":{"rendered":"https:\/\/todaysveterinarypractice.com\/?p=18529"},"modified":"2022-02-18T21:19:04","modified_gmt":"2022-02-18T21:19:04","slug":"dogs-with-lung-cancer-might-benefit-from-treatment-with-human-breast-cancer-drug","status":"publish","type":"post","link":"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/news\/dogs-with-lung-cancer-might-benefit-from-treatment-with-human-breast-cancer-drug\/","title":{"rendered":"Dogs With Lung Cancer Might Benefit From Treatment With Human Breast Cancer Drug"},"content":{"rendered":"<p><em>TGen Press Release<\/em> \u2014 Despite those velvet paintings of poker-playing dogs smoking pipes, cigars and cigarettes, our canine friends really don\u2019t use tobacco. But like many humans who have never smoked, dogs still get lung cancer.<\/p>\n<p>And, like many women who develop a particular type of breast cancer, the same gene \u2014 HER2 \u2014 also appears to be the cause of lung cancer in many dogs, according to a promising new study of pet dogs led by the Translational Genomics Research Institute (<a href=\"https:\/\/www.tgen.org\/\">TGen<\/a>), an affiliate of the City of Hope, and <a href=\"https:\/\/www.osu.edu\/\">The Ohio State University<\/a>.<\/p>\n<p>Published in the journal <em>Clinical Cancer Research<\/em>, this <a href=\"https:\/\/clincancerres.aacrjournals.org\/content\/early\/2019\/08\/20\/1078-0432.CCR-19-1145\">study<\/a> could also have significant implications for people who have never smoked. No dogs were harmed in this study. Only pet dogs with naturally occurring cancer were examined.<\/p>\n<p>TGen and Ohio State found that neratinib \u2014 a drug that has successfully been used to battle human breast cancer \u2014 might work for many of the nearly 40,000 dogs in the U.S. that annually develop the most common type of canine lung cancer, known as canine pulmonary adenocarcinoma, or CPAC.<\/p>\n<h3>Mutant Cancer-Causing Gene<\/h3>\n<p>Neratinib inhibits a mutant cancer-causing form of the gene HER2, which is common to both CPAC and HER2-positive human breast cancer patients.<\/p>\n<p>\u201cWith colleagues at Ohio State, we found a novel HER2 mutation in nearly half of dogs with CPAC. We now have a candidate therapeutic opportunity for a large proportion of dogs with lung cancer,&#8221; said Dr. Will Hendricks, an assistant professor in TGen\u2019s Integrated Cancer Genomics Division, Director of Institutional Research Initiatives, and the study\u2019s senior author.<\/p>\n<p>Based on the results from this study, a clinical trial using neratinib is planned for dogs with naturally occurring lung cancer that have the HER2 mutation.<\/p>\n<p>\u201cThis is the first precision medicine clinical trial for dogs with lung cancer. That is, the selection of cancer therapy for a particular patient is based on the genomic profile of the patient\u2019s tumor and matched with agents that are known to specially target the identified mutation,\u201d said Dr. Wendy Lorch, an associate professor in the Department of Veterinary Clinical Sciences at The <a href=\"https:\/\/vet.osu.edu\/\">Ohio State University College of Veterinary Medicine<\/a>, who also will run the study\u2019s clinical trial.<\/p>\n<h3>An Aggressive Disease<\/h3>\n<p>\u201cOur team at The Ohio State University has worked for years to find treatments for canine lung cancer. This breakthrough shows the value of these studies for dogs, as well as humans with lung cancer who never smoked,\u201d said Dr. Lorch, who also is the study\u2019s lead author.<\/p>\n<p>CPAC is an aggressive disease that clinically resembles human lung cancer among those who have never smoked. There is no standard-of-care treatment for CPAC and \u2014 prior to the work performed by the TGen-Ohio State team \u2014 little was known of the disease\u2019s genetic underpinnings.<\/p>\n<p>\u201cThese results are the first example of our efforts to adapt genomics tools from the human world, such as gene sequencing and liquid biopsies, to generate novel insights in canine cancers, with mutual benefit for both,\u201d said Dr. Muhammed Murtaza, assistant professor and co-director of TGen\u2019s Center for Noninvasive Diagnostics, and one of the study\u2019s contributing authors.<\/p>\n<p>While the sequencing of hundreds of thousands of human cancer genomes has driven the transformational development of precise targeted cancer treatments for humans over the past decade, relatively few canine cancer genomes have undergone similar profiling. The canine cancer genomic discovery and drug development efforts of the TGen-Ohio State team are pieces of a larger puzzle that could similarly transform veterinary oncology, while creating bridges between canine and human cancer drug development.<\/p>\n<p>\u201cThis study is groundbreaking because it not only identified a recurring mutation in a canine cancer that had never been found before, but it actually led directly to a clinical trial,\u201d said Dr. Jeffrey Trent, TGen president and research director, and one of the study\u2019s contributing authors. \u201cThis clinical translation from dog to human and back is the holy grail of comparative cancer research.\u201d<\/p>\n<p>Lung cancer is the leading cause of cancer death in the U.S., annually taking the lives of more than 154,000 Americans.<\/p>\n<h3>Veterinary Industry Support<\/h3>\n<p>\u201cThis study is really exciting to us because, not only have we found a recurrent hot-spot mutation in a canine cancer that had never been found before, but it actually has direct clinical translational relevance,\u201d says Dr. Hendricks. \u201cFor humans, we already have drugs that can inhibit many dysregulated proteins. We hope to show that we can provide the same benefit for dogs with canine cancers.\u201d<\/p>\n<p>This study \u2014 identification of recurrent activating HER2 mutations in primary canine pulmonary adenocarcinoma \u2014 lays the foundation for potential rapid translational development. Follow-up clinical and genomic studies have been funded in part by a $300,000 grant investment from the <a href=\"https:\/\/www.petcofoundation.org\/\">Petco Foundation<\/a> made possible through their <a href=\"https:\/\/www.petcofoundation.org\/events\/pet-cancer-awareness\/\">10-year Pet Cancer Campaign<\/a> in partnership with <a href=\"https:\/\/bluebuffalo.com\/\">Blue Buffalo<\/a>. Susanne Kogut, president of the Petco Foundation, said her organization&#8217;s investment in the next phase of TGen-Ohio State studies is part of a larger effort to improve the health and welfare of pets everywhere.<\/p>\n<p>\u201cWe are so excited to be a part of this study of canine lung cancer, which we hope will rapidly benefit our pet, and pet-parent, communities worldwide,\u201d said Kogut, who in 2016 was named one of 25 \u201cwomen of influence\u201d by <a href=\"http:\/\/www.petage.com\/\">Pet Age magazine<\/a>.<\/p>\n<h3>Learn More<\/h3>\n<blockquote class=\"wp-embedded-content\" data-secret=\"RLLNO9ivOz\"><p><a href=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/oncology\/fundamentals-of-surgical-oncology-in-small-animals\/\">Fundamentals Of Surgical Oncology In Small Animals<\/a><\/p><\/blockquote>\n<p><iframe class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; visibility: hidden;\" title=\"&#8220;Fundamentals Of Surgical Oncology In Small Animals&#8221; &#8212; Today&#039;s Veterinary Practice\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/oncology\/fundamentals-of-surgical-oncology-in-small-animals\/embed\/#?secret=oUcvJSpC3e#?secret=RLLNO9ivOz\" data-secret=\"RLLNO9ivOz\" width=\"500\" height=\"282\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe><\/p>\n<p>Visit the <a href=\"https:\/\/todaysveterinarypractice.com\/category\/clinical-medicine\/oncology\/\">Oncology Archives<\/a> of Today\u2019s Veterinary Practice.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Like many women who develop a particular type of breast cancer, the same gene \u2014 HER2 \u2014 also appears to be the cause of lung cancer in many dogs.<\/p>\n","protected":false},"author":11,"featured_media":18532,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"iawp_total_views":37,"footnotes":""},"categories":[342],"tags":[],"class_list":["post-18529","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-digital-exclusive","column-digital-exclusive","clinical_topics-news"],"acf":{"hide_sidebar":false,"hide_sidebar_ad":false,"hide_all_ads":false},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.7 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Dogs With Lung Cancer Might Benefit From Treatment With Human Breast Cancer Drug | Today&#039;s Veterinary Practice<\/title>\n<meta name=\"description\" content=\"Dogs with lung cancer may benefit from gene-directed treatment with the same drug used to combat a type of human breast cancer.\" 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