{"id":14775,"date":"2018-05-21T21:33:52","date_gmt":"2018-05-21T21:33:52","guid":{"rendered":"http:\/\/todaysveterinarypractice.navc.com\/?p=14647"},"modified":"2022-02-21T15:44:49","modified_gmt":"2022-02-21T15:44:49","slug":"wisdom-health-introduces-groundbreaking-dog-genetics-study","status":"publish","type":"post","link":"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/news\/wisdom-health-introduces-groundbreaking-dog-genetics-study\/","title":{"rendered":"Wisdom Health Introduces Groundbreaking Dog Genetics Study"},"content":{"rendered":"<p><i><span style=\"font-weight: 400\">Via Wisdom Health Press Release:<\/span><\/i><\/p>\n<p><b>Landmark Study Shows Genetic Testing for Dogs Can Help Identify Diseases and Enable Preventive Care for Better Health<\/b><\/p>\n<p><i><span style=\"font-weight: 400\">Largest Canine Genetic Study Reveals Diseases Mixed Breed and Purebred Dogs Are Prone To Develop<\/span><\/i><\/p>\n<p><span style=\"font-weight: 400\">Brussels, Belgium \u2013 May 2, 2018 &#8212; Results from the largest ever study of its kind show that genetic testing can predict if a dog is at risk for developing certain diseases. The study \u201c<\/span><a href=\"http:\/\/journals.plos.org\/plosgenetics\/article?id=10.1371\/journal.pgen.1007361\"><i><span style=\"font-weight: 400\">Frequency and distribution of 152 genetic disease variants in over 100,000 mixed breed and purebred dogs<\/span><\/i><\/a><span style=\"font-weight: 400\">\u201d, published in <\/span><i><span style=\"font-weight: 400\">PLOS Genetics <\/span><\/i><span style=\"font-weight: 400\">was conducted by<\/span><a href=\"http:\/\/www.wisdompanel.com\"> <span style=\"font-weight: 400\">Wisdom Health<\/span><\/a><span style=\"font-weight: 400\"> and<\/span><a href=\"http:\/\/www.mydogdna.com\"> <span style=\"font-weight: 400\">Genoscoper Laboratories<\/span><\/a><span style=\"font-weight: 400\">. This research is the first to show the genetic diseases mixed breed dogs are most likely to develop. The study also shows that fewer mixed breed dogs than purebreds are affected by the most common disease-causing mutations tested in the study. Knowing a dog\u2019s disease-related genetic make-up could enable owners, breeders, and veterinarians to make more informed decisions about a dog\u2019s health. The research was based on genetic testing technology that can be used at home.<\/span><\/p>\n<p><span style=\"font-weight: 400\">\u201cThere has been a long-standing perception that mixed breed dogs are less disease-prone than purebred dogs. This DNA-testing-based evidence shows that while mixed breed dogs are in fact less likely than purebreds to develop the recessive disorders evaluated in the study, they may still be carriers. Importantly it\u2019s now clear that all dogs can benefit from genetic testing,\u201d said Cindy Cole DVM, PhD, DACVCP, General Manager at Wisdom Health. \u201cIt\u2019s exciting that new diagnostic tools are now available to veterinarians, breeders and owners alike to enable them to make more informed decisions about overall care for dogs.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400\">Testing is key to understanding if a dog will be at risk of developing a genetic disease. Based on the 152 diseases tested:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Approximately two out of 100 mixed breed dogs are at risk of becoming affected and 40 out of 100 are carriers for at least one of the diseases.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Approximately five out of 100 purebred dogs are at risk of becoming affected and 28 out of 100 are carriers for at least one of the diseases.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400\">The research also showed that through healthy breeding practices, which often include genetic testing, some diseases appear to have been eradicated from breed pools. With the proactive management of inherited disorders through the use of DNA testing and sustainable breeding decisions, breeders and veterinarians can work to decrease the incidence of genetic diseases in dogs. For example, X-linked Severe Combined Immunodeficiency (XSCID) a mutation originally found in Basset Hounds, appears to have been eradicated.<\/span><\/p>\n<p><span style=\"font-weight: 400\">\u201cFor owners, understanding for which genetic diseases their dog is at risk can help them and their veterinarians design a personalized care and wellness program for \u00a0their dog,\u201d said Jonas Donner, PhD, Chief Scientific Officer at Genoscoper. \u201cMore broadly, for veterinarians to understand which disorders are common across the overall population is extremely valuable information for the future of proactive medical care. \u00a0Using genetic tools to further disease monitoring and eradication in different populations, can, over time have a positive effect on both purebred and mixed breed dogs.\u201d<\/span><\/p>\n<p><b>About the Study<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400\"><a href=\"http:\/\/journals.plos.org\/plosgenetics\/article?id=10.1371\/journal.pgen.1007361\"><span style=\"font-weight: 400\">The study<\/span><\/a><span style=\"font-weight: 400\"> examined the DNA of more than 100,000 dogs, including 18,000 purebreds representing 330 breeds, types and varieties and 83,000 mixed breed dogs, for the presence of 152 genetic disease mutations.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Some of the genetic disease mutations tested include:<\/span>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Progressive Retinal Atrophy \u2013 multiple forms<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Hyperuricosuria<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Collie Eye Anomaly<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Multidrug sensitivity (MDR1)<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">von Willebrand\u2019s Disease \u2013 multiple forms<\/span><\/li>\n<\/ul>\n<\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">The study showed that testing is important to help an owner know if their dog \u00a0is at risk for one of the genetic diseases tested, such as Exercise-induced Collapse (a neuromuscular disorder) and to consult with their veterinarian about a preventative care plan.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">The three body systems most commonly affected across both the pure and mixed breed dog populations in the study were:<\/span>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Vision<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Nervous<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Circulatory<\/span><\/li>\n<\/ul>\n<\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">The study findings underscore the importance of using tools such as the<\/span><a href=\"https:\/\/www.wisdompanel.com\/\"> <span style=\"font-weight: 400\">WISDOM PANEL\u2122 Health<\/span><\/a><span style=\"font-weight: 400\"> canine DNA test, in conjunction with ongoing veterinary care.<\/span><\/li>\n<\/ul>\n<p><b>Resources for Dog Owners<\/b><\/p>\n<p><span style=\"font-weight: 400\">Dog owners looking to take this proactive step in preventative care can test their pets with the new<\/span><a href=\"http:\/\/www.wisdompanel.com\/\"> <span style=\"font-weight: 400\">WISDOM PANEL<\/span> <span style=\"font-weight: 400\">Health<\/span><\/a><span style=\"font-weight: 400\"> canine DNA test. Owners simply swab their dog\u2019s cheek at home, activate their kit online and receive their results two to three weeks from the time their sample reaches the lab. It\u2019s recommended that owners share these results with their veterinarian and discuss future care. Genetic screening for disease and breed detection is easy, inexpensive and readily available as the<\/span><a href=\"http:\/\/www.wisdompanel.com\/\"> <span style=\"font-weight: 400\">WISDOM PANEL<\/span> <span style=\"font-weight: 400\">Health<\/span><\/a> <span style=\"font-weight: 400\">canine DNA test<\/span> <span style=\"font-weight: 400\">includes breed identification for 250+ breeds, types and varieties and detection of more than 150 disease-causing mutations.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Via Wisdom Health Press Release: Landmark Study Shows Genetic Testing for Dogs Can Help Identify Diseases and Enable Preventive Care for Better Health Largest Canine Genetic Study Reveals Diseases Mixed Breed and Purebred Dogs Are Prone To Develop Brussels, Belgium \u2013 May 2, 2018 &#8212; Results from the largest ever study of its kind show<a href=\"https:\/\/navc.\n<\/p>\n","protected":false},"author":17,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"iawp_total_views":8,"footnotes":""},"categories":[342],"tags":[],"class_list":["post-14775","post","type-post","status-publish","format-standard","hentry","category-digital-exclusive","column-digital-exclusive","clinical_topics-news"],"acf":{"hide_sidebar":false,"hide_sidebar_ad":false,"hide_all_ads":false},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.7 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Wisdom Health Introduces Groundbreaking Dog Genetics Study | Today&#039;s Veterinary Practice<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Wisdom Health Introduces Groundbreaking Dog Genetics Study\" \/>\n<meta property=\"og:description\" content=\"Via Wisdom Health Press Release: Landmark Study Shows Genetic Testing for Dogs Can Help Identify Diseases and Enable Preventive Care for Better Health Largest Canine Genetic Study Reveals Diseases Mixed Breed and Purebred Dogs Are Prone To Develop Brussels, Belgium \u2013 May 2, 2018 &#8212; Results from the largest ever study of its kind show\" \/>\n<meta property=\"og:url\" content=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/news\/wisdom-health-introduces-groundbreaking-dog-genetics-study\/\" \/>\n<meta property=\"og:site_name\" content=\"Today&#039;s Veterinary Practice\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/todaysveterinarypractice\" \/>\n<meta property=\"article:published_time\" content=\"2018-05-21T21:33:52+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-02-21T15:44:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/navc.sitepreview.app\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2022\/01\/tvp-logo.png\" \/>\n\t<meta property=\"og:image:width\" content=\"179\" \/>\n\t<meta property=\"og:image:height\" content=\"89\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Eric D. 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