While English veterinary surgeon and author James Herriot treated all creatures great and small, the vast majority of veterinarians today choose to practice within a relatively specific specialty area. As hobby farms become increasingly popular and more and more farm animals are living as pets, there is an increasing need for the return of the traditional mixed animal practitioner. Every veterinarian graduates with the foundational education to care for a broad spectrum of animal species, and it is entirely possible to adopt a mixed animal practice model even well into one’s career in small animal practice. For veterinarians seeking to broaden their services into the realm of equine or mixed animal practice, continuing education is often needed to brush up on preventive healthcare strategies, formulate differential diagnoses lists, and prescribe species-appropriate medications. This edition of Today’s Veterinary Practice seeks to deliver this information with practical, clinically based articles covering common health topics in small ruminant, pet pig, and equine medicine. Preventive healthcare recommendations are reviewed for each species. Formularies have been provided to help practitioners prescribe medications safely and legally. For those interested in equine practice, we included 2 state-of-the-art articles detailing advanced diagnostic imaging and physical rehabilitation, written by field experts Drs. Elizabeth Acutt and Sherry Johnson, respectively. Finally, we also feature renowned veterinary business advisor Dr. Amy Grice who offers strategies on how to incorporate mixed animal practice into your veterinary business model. We hope this special edition of Today’s Veterinary Practice will serve as a valuable tool for established mixed animal practitioners as well as mixed animal–curious veterinarians everywhere.