The most recent AVMA report on the economic state of the veterinary profession shows there is still a wide demand for veterinarians in all sectors, but that most graduates are still preferentially choosing companion animal medicine. Mixed animal medicine makes up approximately 10% while veterinarians who choose strictly equine practice make up closer to 2%. These trends are driven by factors such as geographic distribution, a rising debt load, and compensation differentials. Given these challenges, the need for skilled practitioners who are well-rounded in all aspects of veterinary medicine is essential and highlights the importance of a diverse veterinary education. Even as a veterinarian in small animal practice, there may come a time when it is crucial to be up to date in recent advances in other species. This special issue of Today’s Veterinary Practice aims to provide a glimpse of some of the most important issues that face today’s mixed animal veterinarians. An overview on currently available autologous blood–derived orthobiologics provides an in-depth look at some of the newest and most promising treatments for a common ailment that can result in an early retirement for even the most promising equine athletes. Dr. Albrecht’s article on colic reviews the most common cause of fatality in horses. These articles provide not only background information but also links to products and detailed treatment plans to serve as a convenient and handy resource. I sincerely hope this special edition will not only provide cutting-edge information for those already in the large or mixed animal sphere, but also encourage others to consider a broader scope of practice to help fulfill the needs of our animal community.