{"id":30005,"date":"2023-11-22T21:23:24","date_gmt":"2023-11-22T21:23:24","guid":{"rendered":"https:\/\/todaysveterinarynurse.com\/?p=30005"},"modified":"2024-02-04T13:31:34","modified_gmt":"2024-02-04T13:31:34","slug":"microbiome-targeted-therapies-probiotics-and-fecal-microbiota-transplants","status":"publish","type":"post","link":"https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/nutrition\/microbiome-targeted-therapies-probiotics-and-fecal-microbiota-transplants\/","title":{"rendered":"Microbiome-Targeted Therapies: Probiotics and Fecal Microbiota Transplants"},"content":{"rendered":"<div class=\"su-spacer\" style=\"height:20px\"><\/div><div class=\"su-note\"  style=\"border-color:#d8d8d8;border-radius:3px;-moz-border-radius:3px;-webkit-border-radius:3px;\"><div class=\"su-note-inner su-u-clearfix su-u-trim\" style=\"background-color:#f2f2f2;border-color:#ffffff;color:#333333;border-radius:3px;-moz-border-radius:3px;-webkit-border-radius:3px;\"><b>Abstract<\/b><\/p>\n<p class=\"p1\">Microbiome-targeted therapies involve products that support the gut microbiome in patients experiencing dysbiosis. Choosing the best microbiome-targeted therapy is based on the type of dysbiosis. Probiotics, which work to support dogs and cats with gut dysbiosis, have taken on a large role in pet nutrition. In comparison, fecal microbiota transplantation is gaining attention because it more appropriately addresses all 3 types of gut dysbiosis. Familiarity with the differences in microbiome-targeted therapies can help veterinary nurses explain therapeutic options to clients.<\/p>\n<p><b>Take-Home Points <\/b><\/p>\n<ul>\n<li class=\"p1\">The gut microbiome plays a large role in overall animal health; gut dysbiosis is associated with systemic symptoms and disease.<\/li>\n<li class=\"p1\">The 3 main types of gut dysbiosis in dogs and cats (type 1, missing common microbes; type 2, overgrowth of potentially pathogenic bacteria; or type 3, an imbalanced microbiome) are not mutually exclusive and can occur at the same time.<\/li>\n<li class=\"p1\">Microbiome-targeted therapies (probiotic administration and fecal microbiota transplantation [FMT]) can support a patient with gut dysbiosis by removing potentially harmful microbes and supporting beneficial microbes.<\/li>\n<li class=\"p1\">Both types of microbiome-targeted therapy often work by overwhelming the gut with beneficial microbes that outcompete undesirable microbes for space and nutrients.<\/li>\n<li class=\"p1\">Probiotic administration is most effective for patients with types 2 and 3 dysbiosis; however, probiotics may need to be discontinued before their microbes outcompete the resident microbes and thereby become the overgrown and unfavorable strains.<\/li>\n<li class=\"p1\">FMT is most effective for patients with all 3 types of gut dysbiosis and provides microbes at higher numbers and diversity than probiotics; however, because FMT material also contains other known and unknown substances, donor screening is recommended to reduce the risk of transferring disease to the recipient.<\/li>\n<\/ul>\n<\/div><\/div>\n<p class=\"p1\"><span class=\"s1\">A <\/span><span class=\"s1\">new era of managing pet health is starting to affect specialty and general veterinary practices as the value of maintaining a balanced variety of microbes in the gut becomes better understood. Although microbiomes (the community of microbes in a particular environment, formerly called microflora) are ubiquitous, the gut microbiome has an all-encompassing effect on animal health. The functions of resident gut microbes influence many physiologic systems, and understanding their influence can be helpful when choosing a microbiome-targeted therapy.<sup>1<\/sup> For patients experiencing gut dysbiosis (changes in composition of the gut\u00a0microbiota\u00a0that affect their function), microbiome-targeted therapies can offer support, depending on the type of dysbiosis. Two microbiome-targeted therapies commonly used in veterinary practice are administration of <a href=\"https:\/\/todaysveterinarypractice.com\/nutrition\/probiotics-prebiotics-synbiotics-dogs-cats\/\" target=\"_blank\" rel=\"noopener\">probiotics<\/a> and fecal microbiota transplantation (FMT) (<\/span><span class=\"s2\"><b>TABLE 1<\/b><\/span><span class=\"s1\">). Although probiotic therapy has become more common in recent years, the ancient approach of FMT is gaining the attention of researchers and healthcare professionals.<\/span><\/p>\n<p><img fetchpriority=\"high\" decoding=\"async\" class=\"aligncenter size-full wp-image-30007\" src=\"https:\/\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Saar_TVNWinter24_FMT_Table1.png\" alt=\"\" width=\"2045\" height=\"1134\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Saar_TVNWinter24_FMT_Table1.png 2045w, https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Saar_TVNWinter24_FMT_Table1-300x166.png 300w, https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Saar_TVNWinter24_FMT_Table1-1024x568.png 1024w, https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Saar_TVNWinter24_FMT_Table1-768x426.png 768w, https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Saar_TVNWinter24_FMT_Table1-1536x852.png 1536w\" sizes=\"(max-width: 2045px) 100vw, 2045px\" \/><\/p>\n<h2 class=\"p3\">Why Focus on the Gut Microbiome?<\/h2>\n<p class=\"p2\"><span class=\"s1\">Microbiomes comprise a variety of microbes that function together to support their microscopic environment. Microbiomes are found everywhere, including in and on animals. In ruminants, microbes function in the rumen and are crucial for proper digestion. In monogastric animals, the focus of this article, the largest microbial infrastructure is the gut microbiome in the large intestine.<sup>2<\/sup> The gut microbiome consists of approximately 100 trillion microbes (e.g., bacteria, fungi, protozoa, archaea, viruses) and their genetic components; although microscopic, their effect on physiologic functions is profound.<sup>2<\/sup> The ability of microbes to influence physiologic functions of the host results in part from microbial fermentation of gut ingesta or other energy sources. <\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Much like chemical digestion in the upper gastrointestinal (GI) tract, microbes throughout the GI tract produce chemicals via the breakdown of food sources. Those chemicals are referred to as microbial metabolites, and the collection of all microbial metabolites fermenting a specific food source creates a functional metabolome. The various metabolite functions include influencing the immune system, providing energy, acting as neurotransmitters, assisting with nutrient digestion, reducing inflammation, and playing a role in bile acid recycling.<sup>2,3<\/sup> Some metabolites can cross into the bloodstream, travel to the liver, and then throughout the body via bile, blood, and lymph, completing chemical reactions in other organs, including the brain. That all-encompassing ability makes the gut microbiome a crucial aspect of animal health.<\/span><\/p>\n<h2 class=\"p3\">What are the Microbiome-Targeted Therapies?<\/h2>\n<h3 class=\"p4\">Probiotic Administration<\/h3>\n<p class=\"p2\"><span class=\"s1\">The International Scientific Association for Probiotics and Prebiotics (ISAPP, <\/span><a href=\"http:\/\/isappscience.org\" target=\"_blank\" rel=\"noopener\"><span class=\"s2\">isappscience.org<\/span><\/a><span class=\"s1\">) defines probiotics as \u201clive microorganisms which when administered in adequate amounts confer a health benefit on the host.\u201d<sup>4<\/sup> Probiotics supply the actual microorganisms, whereas prebiotics (not covered in this article) supply nutrients that promote the growth of beneficial\u00a0microbes. According to the ISAPP 2013 consensus statement, probiotics provide a general benefit \u201con gut microbiota that derives from creating a more favorable gut environment, through mechanisms shared by most probiotics.\u201d<sup>4<\/sup> <\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">The general benefits conveyed by probiotics are improved GI signs\/symptoms and immune function.<sup>3<\/sup> Probiotics can be given as supplements or may be incorporated into commercial diets. Probiotic supplements are commercially available in liquid, powder, capsule, and chewable forms. The microbes in probiotics are also present in fermented foods and may be sprayed onto or added to commercial diets. Formulations may include a single strain or a variety of strains. Commonly used bacterial probiotics are species of the lactic acid\u2013producing bacterias <i>Lactobacillus<\/i>, <i>Bifidobacterium<\/i>, <i>Streptococcus<\/i>, and <i>Enterococcus<\/i>. A well-studied fungus (yeast) and commercially available probiotic is <i>Saccharomyces boulardii<\/i>.<sup>5,6<\/sup><\/span><\/p>\n<h3 class=\"p4\">Fecal Microbiota Transplantation<\/h3>\n<p class=\"p2\"><span class=\"s1\">FMT involves collecting feces from a healthy donor and transferring the fecal material to the large intestine of an ill recipient of the same species. Indications for using FMT to treat dysbiosis are based on the ancient theory that a healthy young donor animal would have a normally functioning gut microbiome.<sup>7<\/sup> The ideal donor would be a young adult (full grown but not yet a senior), in good body condition, eating a healthy diet, not taking any medication, and free of medical problems. <\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">The components of FMT material, in addition to beneficial bacteria, include organisms that digest food and produce enzymes, along with unabsorbed metabolites. The transfer of resident gut microbes that were completing normal physiologic functions in the healthy donor can decrease disease-associated symptoms and promote normal body functions in the recipient, thereby improving the recipient\u2019s health status. <\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">However, in addition to identifiable microbes, FMT material also includes unidentified microbes, metabolites, and other components, which could be harmful for the recipient. Thus, for the safety of recipient animals, each batch of FMT material should ideally undergo bacterial fecal microbiota identification and parasite testing.<sup>8<\/sup> <\/span><span class=\"s1\">Microbiome testing tends to focus on bacteria. Common microbiome testing methods available include polymerase chain reaction and next-generation sequencing, which test for bacteria shed in a fresh fecal sample.<sup>9<\/sup> <\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">FMT material can be fresh, frozen, or commercially available lyophilized (freeze-dried), and it can be administered rectally (via retention enema) or orally (in enteric-coated capsules).<sup>7,10<\/sup><\/span><\/p>\n<h2 class=\"p3\">What Affects the Gut Microbiome?<\/h2>\n<p class=\"p2\"><span class=\"s1\">Many factors influence the status of a gut microbiome. The largest shifts in the gut microbiome result from an animal\u2019s presentation at birth (vaginal or surgical delivery), age, sex, diet, environment, genetics, and receipt of antimicrobial drugs.<sup>3,11<\/sup> In addition, dysbiosis can result from repeated administration of antimicrobials to patients with chronic conditions.<sup>12<\/sup> The 3 most common types of dysbiosis in the gut microbiome are missing common microbes, overgrowth of potentially pathogenic bacteria, or an imbalance or loss in the density of common microbes. Types of dysbiosis are not mutually exclusive and can exist at the same time.<sup>13<\/sup><\/span><\/p>\n<h2 class=\"p3\">Microbiome-Targeted Therapy Effects on Dysbiosis<\/h2>\n<h3 class=\"p4\">Type 1: Missing Common Microbes<\/h3>\n<p class=\"p2\"><span class=\"s1\">In patients with gut dysbiosis caused by missing microbes, the goal is to rebalance the microbiome by replacing the specific lost microbes in the gut. The species of missing bacteria need to be identified and their normal functions in the body understood. Knowledge of the species can be used to determine whether the missing bacteria are beneficial or potentially pathogenic. For example, <i>Clostridium hiranonis <\/i>is a key bacterium necessary for transforming primary bile acids into secondary bile acids. Bile acids are compounds made in the\u00a0liver\u00a0that, among other beneficial functions, block the growth of pathogens. Thus, loss of<i> Clostridium hiranonis <\/i>bacteria can result in bile acid\u2013associated diarrhea.<sup>3 <\/sup><\/span><\/p>\n<p class=\"p2\"><span class=\"s1\"><b>Probiotic therapy:<\/b> Currently, probiotic administration is not effective for treating missing microbes because probiotics do not contain, or contain only a few, species-specific resident microbes common in animals. Probiotics are unable to replace all missing species of bacteria.<sup>3<\/sup><\/span><\/p>\n<p class=\"p2\"><span class=\"s1\"><b>Fecal microbiota transplantation:<\/b> The current key to correcting missing microbes is FMT. A healthy donor animal should shed normally functioning species-specific microbes in its feces. FMT material contains the full collection of normal microbes; although fecal transplantation replaces the missing microbes, thereby correcting the dysbiosis, it also introduces other metabolites, waste, and toxins. Thus, to ensure that an animal is a viable donor candidate, its health status and ongoing history must be continually monitored.<sup>7<\/sup><\/span><\/p>\n<h3 class=\"p4\">Type 2: Overgrowth of Pathogenic Bacteria<\/h3>\n<p class=\"p2\"><span class=\"s1\">With regard to microbiome balance, not all bacteria are either strictly beneficial or harmful. The key to good health is a gut microbiome that contains a wide variety of many categories of microbes.<sup>13<\/sup> A higher concentration of beneficial bacteria does not necessarily result in a healthier animal; many bacteria have a beneficial effect when they are part of a balanced microbiome but can have a harmful effect when a select few outcompete and cause a microbiome imbalance. Outcompeting is the displacement of other species in competition for resources. Outcompeting can be used as a therapy to reduce the level of overgrown bacteria and help correct the gut microbiome imbalance.<sup>14<\/sup> It involves supplying a larger amount of 1 or more strains of beneficial bacteria that will compete for space and nutrients. The overgrown bacteria will not be able to sustain their level of growth as they lose nutrients and are unable to replicate.<\/span><\/p>\n<p class=\"p2\"><span class=\"s1\"><b>Probiotic therapy:<\/b> For patients experiencing overgrowth of pathogenic bacteria, probiotics work in an outcompete model in which the microbes (bacteria or fungi) in the probiotic help outcompete unfavorable overgrown microbes in the gut. The goal of administering a probiotic is to elicit a beneficial change in the patient\u2019s gut microbiome. After probiotic administration is discontinued, probiotics should leave (not colonize) the gut, enabling the beneficial resident microbes to flourish without further support from the probiotic. <\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Another way probiotics outcompete is by changing the environment to be less favorable to undesirable microbes. For example, lactic acid bacteria can decrease the environmental pH of the microbiome. A more acidic environment decreases the ability of some resident microbes to function effectively, thereby enabling the lactic acid bacteria to thrive. Thus, administration of probiotics containing lactic acid bacteria may reduce the numbers of unfavorable overgrown bacteria.<sup>15<\/sup> <\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">However, to enable resident microbes to reestablish to normal levels, probiotic administration may need to be discontinued; otherwise, the probiotic microbes may continue to outcompete all the resident microbes in the gut, thereby becoming the overgrown strain and unfavorable bacteria. Further research is needed to determine the appropriate types of bacteria and duration of therapy needed to manage this type of dysbiosis with currently available probiotics.<\/span><\/p>\n<p class=\"p2\"><span class=\"s1\"><b>Fecal microbiota transplantation:<\/b> The goal of transplanting large doses of FMT material into patients with a microbiome experiencing an overgrowth of pathogenic bacteria is to directly rebalance the microbiome by introducing beneficial species-specific microbes that can outcompete the less desirable microbes. Similar to probiotics, outcompeting by the microbes in FMT material will reduce space and nutrients for the undesirable microbes, reducing their ability to continue to replicate. A main advantage of using FMT therapy over probiotic therapy is the higher density (total number) of species-specific microbes in FMT material. In addition, probiotics containing multiple microbes (usually 1 to 3 genera) do not contain the diversity of fecal microbiota (usually \u226525\u00a0genera) in FMT material.<sup>10<\/sup> <\/span><\/p>\n<h3 class=\"p4\">Type 3: Imbalanced Microbiome<\/h3>\n<p class=\"p2\"><span class=\"s1\">Animals with an imbalanced microbiome dysbiosis have all the right microbes, but microbe density or concentration is not balanced. For patients with this type of dysbiosis, microbiome-targeted therapies can decrease associated signs\/symptoms. Probiotics and FMT can each help rebalance the microbiome but can also support a patient with an imbalanced microbiome in other ways. Microbial metabolites can have both beneficial and harmful effects, which may change, depending on the level at which they are produced.<sup>3<\/sup> A collection of metabolites is called a metabolome. A patient with an imbalanced microbiome can experience imbalanced metabolite and metabolome production, and a shift in the volume of metabolites in a metabolome can affect a patient\u2019s health. Inflammatory, neurologic, and\/or behavioral signs\/symptoms may decrease the patient\u2019s health and\/or quality of life. <\/span><\/p>\n<p class=\"p2\"><span class=\"s1\"><b>Probiotic therapy:<\/b> Some probiotic strains are administered to create a large beneficial metabolome. Through production of beneficial metabolites, such as short-chain fatty acids, probiotics can decrease signs\/symptoms associated with an imbalanced microbiome, improve immune function, and decrease inflammation.<sup>16<\/sup> When considering probiotic use, identifying the species of bacteria is imperative to ensure that the patient experiences beneficial, not harmful, effects. Veterinary professionals should use products from reputable companies that have completed research on the strain(s) of microbes in their product and that follow strict production quality control guidelines.<sup>17<\/sup><\/span><\/p>\n<p class=\"p2\"><span class=\"s1\"><b>Fecal microbiota transplantation:<\/b> FMT material contains residual metabolomes along with a variety of microbes able to create multiple metabolomes. Benefits of administering FMT material are that the metabolomes produced will contribute to normal function in a healthy gut and that the microbes will rebalance the state of the gut microbiome.<sup>18<\/sup> <\/span><\/p>\n<h2 class=\"p3\">Summary<\/h2>\n<p class=\"p2\"><span class=\"s1\">Before prescribing an antimicrobial drug for a patient with GI signs\/symptoms, veterinary professionals should consider the functions of the gut microbiome. Identifying the type of dysbiosis a patient is experiencing will help indicate the best microbiome-targeted therapy to resolve the associated signs\/symptoms and their cause. The type and severity of the dysbiosis indicate which product can best support the components of the gut microbiome, improve barrier function, increase production of beneficial metabolites, and correct the dysbiosis. <\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">At this time, there are no probiotics to replace all common missing resident bacteria; rather, probiotics serve the purposes of outcompeting and producing beneficial metabolites. Recommended probiotics should have undergone species-specific studies, include species-level microbes, and should be prescribed according to the desired outcome. FMT material has the potential to better support microbiomes that are missing microbes and to correct microbial diversity that has become unbalanced, particularly after antimicrobial use. However, FMT material carries the risk of transferring unidentified components, which may or may not be harmful to the recipient, thereby emphasizing the value of completing the rigorous and sometimes difficult task of donor selection. The best way to ensure safety and positive outcomes for FMT material recipients is to extensively and frequently screen potential donors. <\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Identifying the type of dysbiosis a patient is experiencing will help indicate the best microbiome-targeted therapy to resolve the associated gastrointestinal symptoms and their cause.<\/p>\n","protected":false},"author":236,"featured_media":30006,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"iawp_total_views":0,"footnotes":""},"categories":[242],"tags":[145],"class_list":["post-30005","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-winter-2024","tag-peer-reviewed","column-nutrition_notes","clinical_topics-gastroenterology","clinical_topics-nutrition"],"acf":{"hide_sidebar":false,"hide_sidebar_ad":false,"hide_all_ads":false},"yoast_head":"<!-- This site is optimized 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