{"id":29958,"date":"2023-11-22T21:16:27","date_gmt":"2023-11-22T21:16:27","guid":{"rendered":"https:\/\/todaysveterinarynurse.com\/?p=29958"},"modified":"2026-02-06T13:53:37","modified_gmt":"2026-02-06T13:53:37","slug":"anesthetizing-the-critical-care-small-animal-patient","status":"publish","type":"post","link":"https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/emergency-medicine-critical-care\/anesthetizing-the-critical-care-small-animal-patient\/","title":{"rendered":"Anesthetizing the Critical-Care Patient"},"content":{"rendered":"<div class=\"su-spacer\" style=\"height:20px\"><\/div><div class=\"su-note\"  style=\"border-color:#d8d8d8;border-radius:3px;-moz-border-radius:3px;-webkit-border-radius:3px;\"><div class=\"su-note-inner su-u-clearfix su-u-trim\" style=\"background-color:#f2f2f2;border-color:#ffffff;color:#333333;border-radius:3px;-moz-border-radius:3px;-webkit-border-radius:3px;\"><b>Abstract<\/b><\/p>\n<p class=\"p1\">The critical-care patient requiring anesthesia is at high risk for life-threatening complications during the perianesthesia period. Preoperative stabilization can be difficult, and the decision to induce anesthesia can be guided by goal-directed therapies. During the perioperative period, close monitoring of vital parameters will guide clinical interventions. The recovery period is just as critical as the induction period, and diligent monitoring and supportive care during that time should not be undervalued.<\/p>\n<p><b>Take-Home Points <\/b><\/p>\n<ul>\n<li class=\"p1\">Preoperative patient stabilization will help set up the anesthetist for perioperative success.<\/li>\n<li class=\"p1\">When possible, vascular access (e.g., peripheral IV catheters, multilumen central lines, arterial catheters) should be obtained before anesthesia is induced.<\/li>\n<li class=\"p1\">Large-volume fluid resuscitation is detrimental in the long term; thus, balanced fluid support includes use of blood products and vasopressor therapy.<\/li>\n<li class=\"p1\">Monitoring equipment (e.g., electrocardiography equipment, pulse oximeter, blood pressure cuff) should be used during the induction period.<\/li>\n<li class=\"p1\">Following a balanced multimodal anesthetic plan will reduce the need for inhalant anesthetics and subsequently limit cardiovascular depression.<\/li>\n<li class=\"p1\">Vasopressor therapy may be needed to maintain a mean arterial pressure of &gt;60 mm Hg.<\/li>\n<li class=\"p1\">Ventilatory support (i.e., positive-pressure ventilation) may be needed.<\/li>\n<li class=\"p1\">Recovery is a critical period, and supportive care and monitoring should continue while the patient is moved out of the surgical suite.<\/li>\n<\/ul>\n<\/div><\/div>\n<p class=\"p1\"><span class=\"s1\">A<\/span><span class=\"s1\">nesthetizing the critical-care patient can be a daunting task for the veterinary nurse anesthetist. Balancing an appropriate surgical anesthetic plane with the inherent cardiopulmonary depressive effects of injectable and inhalant anesthetics can be clinically challenging. This article provides tips for how to use a balanced multimodal approach to support the critical-care patient through the pre-, peri-, and postoperative periods.<\/span><\/p>\n<h2 class=\"p3\">Preoperative Period<\/h2>\n<p class=\"p2\"><span class=\"s1\">Deciding when to anesthetize a critically ill patient is subjective and will depend on the patient\u2019s response to stabilization attempts. Stabilizing the critical-care patient is similar to stabilizing the <a href=\"https:\/\/todaysveterinarynurse.com\/emergency-medicine-critical-care\/systemic-inflammatory-response-syndrome-and-sepsis\/\" target=\"_blank\" rel=\"noopener\">systemic inflammatory response syndrome (SIRS)\/sepsis<\/a> patient. Goal-directed therapy should be used to tailor treatments to the patient\u2019s clinical needs (<\/span><span class=\"s2\"><b>TABLE 1<\/b><\/span><span class=\"s1\">).<\/span><\/p>\n<p><img fetchpriority=\"high\" decoding=\"async\" class=\"aligncenter size-full wp-image-29966\" src=\"https:\/\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Table1-1.png\" alt=\"\" width=\"2043\" height=\"948\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Table1-1.png 2043w, https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Table1-1-300x139.png 300w, https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Table1-1-1024x475.png 1024w, https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Table1-1-768x356.png 768w, https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Table1-1-1536x713.png 1536w\" sizes=\"(max-width: 2043px) 100vw, 2043px\" \/><\/p>\n<h3 class=\"p4\">Fluid Therapy<\/h3>\n<p class=\"p2\"><span class=\"s1\">Critical-care patients benefit from early <a href=\"https:\/\/todaysveterinarynurse.com\/internal-medicine\/fluid-calculations-keeping-a-balance\/\" target=\"_blank\" rel=\"noopener\">fluid resuscitation<\/a> because of hypovolemia, dehydration, and hemostatic dysregulation leading to reduced oxygen delivery to the tissues.<sup>1<\/sup> Early treatment with crystalloid fluids, specifically goal-driven administration via small-volume resuscitation, can aid in oxygen delivery and arterial blood pressure management. Small-volume resuscitation is based on the concept that fluid therapy is driven by reaching clinical goals.<sup>4<\/sup> Example goals include decreased heart rate in the tachycardic patient or a mean arterial blood pressure (MAP) of &gt;60 mm Hg in the hypotensive patient. For small-volume resuscitation, isotonic crystalloid fluid boluses of 5 to 10 mL\/kg are administered while carefully monitoring for response to fluid therapy.<\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Intravascular longevity of crystalloid fluids is short; only an estimated 70% to 80% remains in the vasculature after 30 minutes; thus, the response of severely ill patients to initial crystalloid therapy may be poor or short-lived.<sup>1<\/sup> However, care should be taken to avoid large-volume resuscitation as continued administration of fluid boluses can damage the endothelial glycocalyx (endothelial cell lining) and lead to vascular leakage and edema formation.<sup>5<\/sup> Use of hypertonic crystalloids (e.g., hypertonic saline) may promote an osmotic shift of fluid from the interstitial space into the intravascular space, with effects lasting 2 to 4 hours; continued isotonic fluid therapy will be needed to prevent interstitial dehydration.<sup>3<\/sup><\/span><\/p>\n<h3 class=\"p4\">Blood Product Administration<\/h3>\n<p class=\"p2\"><span class=\"s1\"><a href=\"https:\/\/todaysveterinarynurse.com\/hematology\/blood-transfusions-in-anemic-dogs-and-cats\/\" target=\"_blank\" rel=\"noopener\">Blood products<\/a> serve a multitude of purposes, including treating anemia and hypoproteinemia, acting as a natural colloid prolonging intravascular volume, and treating coagulopathies. Fast preoperative administration of packed red blood cells (pRBCs) to anemic patients, to maintain a packed cell volume (PCV) greater than 20%, is preferable but not always attainable in very large canine patients or in feline patients when pRBC units are a fixed volume. Preoperatively, patients with a severe coagulopathy should receive a transfusion of fresh frozen plasma (FFP), often administered as a slow bolus to critical-care patients, depending on volume status.<\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">The author prefers to use FFP as a natural colloid for SIRS\/sepsis patients to maintain intravascular volume and correct hypotension secondary to hypovolemia. Studies of humans indicate that administration of plasma reduces proinflammatory mediators and endothelial glycocalyx degradation in patients with sepsis.<sup>5<\/sup> FFP may be administered to septic patients as a small-volume bolus of 1 to 2 mL\/kg, followed by a continuous-rate infusion (CRI) at 1 to 2+ mL\/kg.<\/span><\/p>\n<h3 class=\"p4\">Vasoactive Drug Support<\/h3>\n<p class=\"p2\"><span class=\"s1\">Early use of vasopressors reduces death rates.<sup>6<\/sup> Patients should be euhydrated; however, for critical-care patients, that is not always achievable. Choice of vasoactive drug should be tailored to the desired clinical response; however, for the critical-care patient, use is primarily geared toward increasing arterial blood pressure.<\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Vasoactive drugs act primarily on 4 adrenergic receptors: <\/span><span class=\"s3\">\u03b2<\/span><span class=\"s1\">1 receptor agonists, which increase heart rate and contractility; <\/span><span class=\"s3\">\u03b2<\/span><span class=\"s1\">2 receptor agonists, which cause vasodilation; and <\/span><span class=\"s3\">\u03b1<\/span><span class=\"s1\">1 and <\/span><span class=\"s3\">\u03b1<\/span><span class=\"s1\">2 receptor agonists, which cause vasoconstriction. Vasopressors pose a risk for phlebitis if administered perivascularly and thus should always be diluted (<\/span><span class=\"s2\"><b>BOX 1<\/b><\/span><span class=\"s1\">).<sup>7<\/sup> Diluent options include sodium chloride or dextrose 5% in water.<\/span><\/p>\n<div class=\"su-box su-box-style-default\" id=\"\" style=\"border-color:#606060;border-radius:3px;\"><div class=\"su-box-title\" style=\"background-color:#939393;color:#FFFFFF;border-top-left-radius:1px;border-top-right-radius:1px\">BOX 1 Diluted Vasopressor Calculations<\/div><div class=\"su-box-content su-u-clearfix su-u-trim\" style=\"border-bottom-left-radius:1px;border-bottom-right-radius:1px\"><strong>Patient weight:<\/strong> 25 kg<\/p>\n<p><strong>Drug:<\/strong> Dobutamine 12.5 mg\/mL<\/p>\n<p><strong>Dose:<\/strong> 10 \u00b5g\/kg\/min running at 10 mL\/hr for 2 hr<\/p>\n<p><strong>Calculations<\/strong><\/p>\n<ol>\n<li>(25 kg \u00d7 10 \u00b5g\/kg\/min \u00d7 60 min\/hr) \/ 1000 \u00b5g\/mg = 15 mg\/hr dobutamine<\/li>\n<li>15 mg\/hr \/ 12.5 mg\/mL = 1.2 mL\/hr dobutamine<\/li>\n<li>1.2 mL\/hr \u00d7 2 hr = <strong>2.4 mL total dobutamine <\/strong><\/li>\n<li>2 hr \u00d7 10 mL\/hr = 20 mL diluent \u2013 2.4 mL dobutamine = <strong>17.6 mL diluent<\/strong><\/div><\/div><\/li>\n<\/ol>\n<p class=\"p6\"><b>Dobutamine<\/b><\/p>\n<p class=\"p2\"><span class=\"s1\">Dobutamine has strong <\/span><span class=\"s3\">\u03b2<\/span><span class=\"s1\"><sub>1<\/sub> effects along with some <\/span><span class=\"s3\">\u03b2<\/span><span class=\"s1\"><sub>2<\/sub> and <\/span><span class=\"s3\">\u03b1<\/span><span class=\"s1\"><sub>1<\/sub> effects (strong changes to heart rate and contractility and thus cardiac output). Dobutamine is used primarily for patients that have poor cardiac output but do not need strong augmentation of blood pressure. An example of a critical-care patient that may benefit from dobutamine is one with uncontrolled dilated cardiomyopathy needing to undergo anesthesia. In cats, dobutamine should be used with caution and at lower doses (5 \u00b5g\/kg\/min) as it can cause seizures.<sup>8<\/sup><\/span><\/p>\n<p class=\"p6\"><b>Dopamine<\/b><\/p>\n<p class=\"p2\"><span class=\"s1\">Dopamine is a precursor to norepinephrine and has strong <\/span><span class=\"s3\">\u03b2<\/span><span class=\"s1\"> and <\/span><span class=\"s3\">\u03b1<\/span><span class=\"s1\"> activity (e.g., stimulating the release of norepinephrine). It also uniquely has dopamine receptor activity, which causes arterial vasodilation. The effects of dopamine are dose dependent. Low doses (1 to 3 \u00b5g\/kg\/min) lead primarily to dopaminergic arterial vasodilation; moderate doses (5 to 10 \u00b5g\/kg\/min) lead primarily to the <\/span><span class=\"s3\">\u03b2<\/span><span class=\"s1\"> effects of increased heart rate and contractility; and high doses (&gt;15 \u00b5g\/kg\/min) lead primarily to the <\/span><span class=\"s3\">\u03b1<\/span><span class=\"s1\"> effects of vasoconstriction.<sup>8<\/sup><\/span><\/p>\n<p class=\"p6\"><b>Norepinephrine<\/b><\/p>\n<p class=\"p2\"><span class=\"s1\">Norepinephrine has primarily <\/span><span class=\"s3\">\u03b1<\/span><span class=\"s1\"> effects leading to vasoconstriction and may variably have weak <\/span><span class=\"s3\">\u03b2<\/span><span class=\"s1\"><sub>1<\/sub> activity leading to changes in heart rate and contractility, which depend on patient status. Because <\/span>hypovolemic animals tend to already be vasoconstricted,<span class=\"s1\"> further vasoconstriction may decrease venous return and thus cardiac output. Norepinephrine may be used with dopamine if both vasoconstriction and strong inotropic effects are required.<sup>9<\/sup> For SIRS\/sepsis patients, norepinephrine is the vasopressor of choice.<sup>10<\/sup><\/span><\/p>\n<p class=\"p6\"><b>Epinephrine<\/b><\/p>\n<p class=\"p2\"><span class=\"s1\">Epinephrine is a strong <\/span><span class=\"s3\">\u03b2<\/span><span class=\"s1\"> and <\/span><span class=\"s3\">\u03b1<\/span><span class=\"s1\"> agonist, causing profound vasoconstriction and strong changes in heart rate and contractility and thus in cardiac output. Unfortunately, epinephrine can also cause unwanted negative side effects (e.g., sinus tachycardia, ventricular arrhythmias, hyperlactatemia).<sup>8<\/sup> Clinical use of epinephrine is primarily reserved for use when alternative vasopressor therapy has failed.<\/span><\/p>\n<h3 class=\"p4\">Vascular Access<\/h3>\n<p class=\"p2\"><span class=\"s1\">Critical-care patients require advanced vascular access because they often require multiple CRIs and undergo repeated blood sampling. The author\u2019s guideline is American Society of Anesthesiologists (ASA,<\/span><a href=\"http:\/\/asahq.org\" target=\"_blank\" rel=\"noopener\"><span class=\"s2\"> asahq.org<\/span><\/a><span class=\"s1\">) status minus 1 for vascular access sites (with a minimum of 1). <\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Before anesthesia induction, ASA 5 patients should undergo placement of a multilumen central venous catheter, if clinically possible. Central multilumen catheters provide the ability to run multiple infusions at once into different lumens, administer hyperosmolar solutions (e.g., high percentage dextrose) with decreased risk for phlebitis, and collect serial blood samples (<\/span><span class=\"s2\"><b>FIGURE 1<\/b><\/span><span class=\"s1\">). Vascular access in critical-care patients can be extremely difficult, and difficulty may increase after administration of vasopressors.<\/span><\/p>\n<div class=\"su-image-carousel  su-image-carousel-has-spacing su-image-carousel-crop su-image-carousel-crop-4-3 su-image-carousel-has-outline su-image-carousel-adaptive su-image-carousel-slides-style-default su-image-carousel-controls-style-dark su-image-carousel-align-center\" style=\"max-width:80%\" data-flickity-options='{\"groupCells\":true,\"cellSelector\":\".su-image-carousel-item\",\"adaptiveHeight\":false,\"cellAlign\":\"left\",\"prevNextButtons\":true,\"pageDots\":false,\"autoPlay\":5000,\"imagesLoaded\":true,\"contain\":true,\"selectedAttraction\":0.025,\"friction\":0.28}' id=\"su_image_carousel_69e8eb858fc81\"><div class=\"su-image-carousel-item\"><div class=\"su-image-carousel-item-content\"><img decoding=\"async\" width=\"719\" height=\"1024\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Fig1A-1.png\" class=\"\" alt=\"\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Fig1A-1.png 720w, https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Fig1A-1-211x300.png 211w\" sizes=\"(max-width: 719px) 100vw, 719px\" \/><span>Figure 1. Example of a central line in a critical-care patient. (A) Central line secured in place.<\/span><\/div><\/div><div class=\"su-image-carousel-item\"><div class=\"su-image-carousel-item-content\"><img decoding=\"async\" width=\"864\" height=\"648\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Fig1B-1.png\" class=\"\" alt=\"\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Fig1B-1.png 864w, https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Fig1B-1-300x225.png 300w, https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Fig1B-1-768x576.png 768w\" sizes=\"(max-width: 864px) 100vw, 864px\" \/><span>Figure 1B. Radiographic image of the central line.<\/span><\/div><\/div><\/div><script id=\"su_image_carousel_69e8eb858fc81_script\">if(window.SUImageCarousel){setTimeout(function() {window.SUImageCarousel.initGallery(document.getElementById(\"su_image_carousel_69e8eb858fc81\"))}, 0);}var su_image_carousel_69e8eb858fc81_script=document.getElementById(\"su_image_carousel_69e8eb858fc81_script\");if(su_image_carousel_69e8eb858fc81_script){su_image_carousel_69e8eb858fc81_script.parentNode.removeChild(su_image_carousel_69e8eb858fc81_script);}<\/script>\n<p class=\"p6\"><b>Venous Access<\/b><\/p>\n<p class=\"p2\"><span class=\"s1\">Common venous access sites in canine and feline patients include the cephalic and cephalic accessory veins, the medial and lateral saphenous veins, and the jugular veins. <a href=\"https:\/\/todaysveterinarynurse.com\/emergency-medicine-critical-care\/uncommon-iv-catheter-sites-in-small-animals\/\" target=\"_blank\" rel=\"noopener\">Uncommon venous access sites<\/a> for patients of both species include the dorsal pedal veins; in dogs, unusual sites include the auricular vein (conformation dependent) and the dorsal metacarpal veins.<\/span><\/p>\n<p class=\"p6\"><b>Blood Sampling<\/b><\/p>\n<p class=\"p2\"><span class=\"s1\">Improper sampling technique can lead to fatal clinical decisions; thus, correct sampling technique with a multilumen central catheter is paramount.<sup>9<\/sup> Because of the risk of falsely elevated blood glucose levels when administering high-percentage dextrose dilutions, 1\u00a0lumen should not be used for dextrose infusions, if possible, and should be reserved strictly for sampling. In addition, during sampling, all dextrose infusions should be paused to prevent incorrect measurements of glucose concentrations.<\/span><\/p>\n<p class=\"p6\"><b>Arterial Access Sites<\/b><\/p>\n<p class=\"p2\"><span class=\"s1\">Depending on predisposing risk factors, critically ill anesthesia patients may benefit from arterial catheter placement for monitoring invasive blood pressures and collecting serial arterial blood samples. Although technically challenging, particularly in critical-care patients with preexisting hypotension, the ability to have direct, real-time arterial blood pressure measurements and to assess and monitor ventilation\/oxygenation status will help guide more rapid clinical decisions. Typical placement sites include the metatarsal, coccygeal, auricular, radial, and lingual arteries (the downside of lingual artery placement is that the catheter will need to be removed before recovery) (<\/span><span class=\"s2\"><b>FIGURE 2<\/b><\/span><span class=\"s1\">). <\/span><\/p>\n<div class=\"su-image-carousel  su-image-carousel-has-spacing su-image-carousel-crop su-image-carousel-crop-4-3 su-image-carousel-has-outline su-image-carousel-adaptive su-image-carousel-slides-style-default su-image-carousel-controls-style-dark su-image-carousel-align-center\" style=\"max-width:80%\" data-flickity-options='{\"groupCells\":true,\"cellSelector\":\".su-image-carousel-item\",\"adaptiveHeight\":false,\"cellAlign\":\"left\",\"prevNextButtons\":true,\"pageDots\":false,\"autoPlay\":5000,\"imagesLoaded\":true,\"contain\":true,\"selectedAttraction\":0.025,\"friction\":0.28}' id=\"su_image_carousel_69e8eb85902c7\"><div class=\"su-image-carousel-item\"><div class=\"su-image-carousel-item-content\"><img loading=\"lazy\" decoding=\"async\" width=\"720\" height=\"960\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Fig2A-1.png\" class=\"\" alt=\"\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Fig2A-1.png 720w, https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Fig2A-1-225x300.png 225w\" sizes=\"(max-width: 720px) 100vw, 720px\" \/><span>Figure 2A. Lingual arterial catheter.<\/span><\/div><\/div><div class=\"su-image-carousel-item\"><div class=\"su-image-carousel-item-content\"><img loading=\"lazy\" decoding=\"async\" width=\"1008\" height=\"677\" src=\"https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Fig2B-1.png\" class=\"\" alt=\"\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Fig2B-1.png 1008w, https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Fig2B-1-300x201.png 300w, https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Fig2B-1-768x516.png 768w\" sizes=\"(max-width: 1008px) 100vw, 1008px\" \/><span>Figure 2B. Invasive blood pressure displayed on monitor in a critical-care patient.<\/span><\/div><\/div><\/div><script id=\"su_image_carousel_69e8eb85902c7_script\">if(window.SUImageCarousel){setTimeout(function() {window.SUImageCarousel.initGallery(document.getElementById(\"su_image_carousel_69e8eb85902c7\"))}, 0);}var su_image_carousel_69e8eb85902c7_script=document.getElementById(\"su_image_carousel_69e8eb85902c7_script\");if(su_image_carousel_69e8eb85902c7_script){su_image_carousel_69e8eb85902c7_script.parentNode.removeChild(su_image_carousel_69e8eb85902c7_script);}<\/script>\n<p class=\"p2\"><span class=\"s1\">Placement of an arterial catheter before anesthesia induction can be attempted but, depending on the patient and placement site, may not be tolerated. Attempts may be repeated after induction, as clinically necessary. For arterial catheters in cats, care should be taken to remove them as soon as clinically possibly as they can potentially lead to increased ischemic injury at the catheter site.<sup>11<\/sup><\/span><\/p>\n<h3 class=\"p4\">Anesthesia Planning<\/h3>\n<p class=\"p2\"><span class=\"s1\">Anesthesia of critical-care patients should be multimodal (a balance of different drugs with different mechanisms of action administered by various routes). Drug selection will vary from case to case but should be patient-specific. Examples include preexisting renal or hepatic disease limiting medication clearance (e.g., renal metabolization of ketamine in the cat) and hepatic clearance of midazolam in patients with liver dysfunction.<sup>12<\/sup> Concurrent drug therapy should also be considered (e.g., recent administration of steroids and nonsteroidal anti-inflammatory drugs). In general, inhalant anesthetics cause significant cardiovascular depression, and use in critical-care patients should be limited; multimodal anesthesia should be used instead. Species-specific issues should be considered (e.g., infusions of propofol injectable emulsion in cats and their intolerance of benzyl alcohol, the use of lidocaine in cats and negative cardiovascular effects).<sup>13<\/sup> When using inhalant anesthetics for critical-care patients, keep in mind that minimum alveolar concentration is decreased when CRIs are concurrently administered.<\/span><\/p>\n<h3 class=\"p4\">Surgical Suite and Patient Preparation<\/h3>\n<p class=\"p6\"><b>Suite Preparation<\/b><\/p>\n<p class=\"p2\"><span class=\"s1\">Before the patient undergoes anesthesia induction, the surgical suite should be completely prepared to reduce total anesthetic time as well as the possibility of distraction during the critical perianesthetic period. Preparation should include readying the sterile table and having all potential surgical equipment available in the room, leak testing and setting up the anesthesia machine and monitoring equipment, and setting up quick access to potential emergency drugs. For critical-care patients, careful forethought can help reduce the likelihood of treatment delays. Potentially needed blood products and administration pumps, fluid\/syringe pumps, extension sets, and Y-ports should be readily available; for severe cases, a dose of emergency drugs may even be predrawn. If a surgical ventilator is available, it should be outfitted with the correct size bellows and be quickly accessible in the event of apnea.<\/span><\/p>\n<p class=\"p6\"><b>Patient Preparation<\/b><\/p>\n<p class=\"p2\"><span class=\"s1\">For patients with known or suspected gastric distension, preplacement of a nasogastric tube to allow for gastric emptying may reduce the risk for life-threatening aspiration during induction. The risk may be further reduced by administering antiemetics before anesthesia. In anticipation of possible regurgitation during induction, a suction device should be available. <a href=\"https:\/\/todaysveterinarypractice.com\/anesthesiology\/anesthesia-and-analgesia-in-brachycephalic-dogs\/\" target=\"_blank\" rel=\"noopener\">Brachycephalic breeds<\/a> may require multimodal antiemetic\/prokinetic therapy, including metoclopramide, maropitant, and ondansetron. To further reduce anesthesia time, the surgical site should be prepared (e.g., preshaved) before induction when possible.<\/span><\/p>\n<h3 class=\"p4\">Anesthesia Induction<\/h3>\n<p class=\"p2\"><span class=\"s1\">The most critical time during the perioperative anesthetic period is induction. Administration of premedication and induction drugs diminishes the patient\u2019s ability to continue the compensatory mechanisms that are responding to critical disease processes. There is no safe induction combination, and the patient should be monitored and supported very closely during induction.<\/span><\/p>\n<p class=\"p6\"><b>Preoxygenation<\/b><\/p>\n<p class=\"p2\"><span class=\"s1\">Before anesthesia induction, critical-care patients should be preoxygenated for 5 to 10 minutes, particularly brachycephalic breeds and patients that may require a prolonged intubation time (e.g., cats). Preoxygenation increases oxygen reserves to reduce the risk for hypoxemia during the induction period.<\/span><\/p>\n<p class=\"p6\"><b>Monitoring<\/b><\/p>\n<p class=\"p2\"><span class=\"s1\">During induction, the critical-care patient requires intensive monitoring and support. In routine clinical practice, the standard order of procedures is often inducing anesthesia, positioning the patient for preparation of the surgical site, and then applying monitoring equipment. However, for the critical-care patient, monitoring equipment (e.g., electrocardiography [ECG] leads, a pulse oximeter, a blood pressure cuff) should be placed before induction and an initial reading taken or direct arterial monitoring should be initiated. <\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">A recent minimum database, performed preferably in the past 10 to 15\u00a0minutes, should be available. A minimum database includes a PCV, total protein (TP), and blood glucose and lactate levels. Before induction begins, hypoglycemia should be treated with 0.5 to 1 mL\/kg of 50% dextrose diluted 1:3, and patients with persistent hypoglycemia should be evaluated for the need of 2.5+% dextrose supplementation in their maintenance fluids. PCV\/TP readings can help drive clinical decisions on fluid balance during the perioperative period because patients with a high PCV\/TP level are probably dehydrated and may be more responsive to fluid therapy to correct hypotension. Elevated blood lactate levels indicate anaerobic metabolism and thus continued poor oxygen delivery.<sup>14<\/sup><\/span><\/p>\n<p class=\"p6\"><b>Induction Agents<\/b><\/p>\n<p class=\"p2\"><span class=\"s1\">Common induction medication choices include premedication with a pure \u00b5 opioid and a benzodiazepine (e.g., methadone, fentanyl, midazolam) (<\/span><span class=\"s2\"><b>TABLE 2<\/b><\/span><span class=\"s1\">). Pure \u00b5 opioids allow for optimal pain control, and benzodiazepines assist with sedation. That combination, known as neuroleptanalgesia (the combination of an opioid with an anxiolytic), may be adequate for intubating the critical-care patient.<sup>15<\/sup> If <\/span>additional sedation is needed to achieve swift intubation,<span class=\"s1\"> a titratable induction agent (e.g., propofol, alfaxalone) may be necessary. <\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Propofol induces anesthesia when titrated over 60 to 90\u00a0seconds, and its effect lasts approximately 10 minutes. Negative side effects, including dose-dependent apnea and transient vasodilatory hypotension, may be more prevalent in the critical-care patient.<sup>15<\/sup> Alfaxalone, like propofol, induces anesthesia with slow titration over 1 to 2 minutes; <\/span>clinical effects last approximately 10 minutes.<sup>15<\/sup> Previous research suggested that alfaxalone caused less respiratory<span class=\"s1\"> depression than propofol, although recent research has shown a similar degree of respiratory depression.<sup>16<\/sup> Clinically, both alfaxalone and propofol cause dose-dependent apnea and cardiovascular depression.<\/span><\/p>\n<div id=\"attachment_29967\" style=\"width: 410px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-29967\" class=\"wp-image-29967 \" src=\"https:\/\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Table2-1.png\" alt=\"\" width=\"400\" height=\"318\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Table2-1.png 982w, https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Table2-1-300x238.png 300w, https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Table2-1-768x610.png 768w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><p id=\"caption-attachment-29967\" class=\"wp-caption-text\"><span style=\"color: #ffffff\">.<\/span><\/p><\/div>\n<p class=\"p6\"><b>Induction Follow-up<\/b><\/p>\n<p class=\"p2\"><span class=\"s1\">After intubation, positioning the patient in the surgical suite and complete surgical preparation can follow. Ventilation should be carefully monitored as critical-care patients may require ventilatory support with positive-pressure ventilation (PPV) after induction. Additional monitoring equipment should be swiftly placed, including a capnograph for end-tidal carbon dioxide (ETco<sub>2<\/sub>) monitoring. Ideally, an assistant can help during the preparation period so the anesthetist can focus on patient monitoring.<\/span><\/p>\n<h2 class=\"p3\">Perioperative Period<\/h2>\n<h3 class=\"p4\">Anesthetic Plane Maintenance<\/h3>\n<p class=\"p2\"><span class=\"s1\">Maintaining anesthesia should be focused on keeping the patient in a light surgical plane and quickly troubleshooting any changes in vital parameters. Although general anesthesia is commonly maintained with inhalants, use of a balanced multimodal protocol should decrease cardiovascular depression. CRIs should be used to reduce anesthetic gas requirements (<\/span><span class=\"s2\"><b>TABLE\u00a03<\/b><\/span><span class=\"s1\">). CRIs that control analgesia include opioids (e.g., fentanyl, methadone) and lidocaine (in the canine patient). <\/span><\/p>\n<div id=\"attachment_29968\" style=\"width: 411px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-29968\" class=\" wp-image-29968\" src=\"https:\/\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Table3-1.png\" alt=\"\" width=\"401\" height=\"345\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Table3-1.png 978w, https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Table3-1-300x258.png 300w, https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Table3-1-768x660.png 768w\" sizes=\"(max-width: 401px) 100vw, 401px\" \/><p id=\"caption-attachment-29968\" class=\"wp-caption-text\"><span style=\"color: #ffffff\">.<\/span><\/p><\/div>\n<p class=\"p2\"><span class=\"s1\">Ketamine, a dissociative drug, is an excellent anesthesia supplement for reducing the need for cardiodepressive anesthetics in dogs and cats.<sup>17<\/sup> Use of CRIs will allow for reduced concentrations, and potentially elimination, of inhalant anesthetics, as well as titratable management of negative side effects (e.g., anesthesia-induced hypotension). The author prefers to use multimodal total intravenous anesthesia for critical-care patients (<\/span><span class=\"s2\"><b>FIGURE 3<\/b><\/span><span class=\"s1\">).<\/span><\/p>\n<div id=\"attachment_29963\" style=\"width: 360px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-29963\" class=\" wp-image-29963\" src=\"https:\/\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Fig3-1.png\" alt=\"\" width=\"350\" height=\"467\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Fig3-1.png 720w, https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Fig3-1-225x300.png 225w\" sizes=\"(max-width: 350px) 100vw, 350px\" \/><p id=\"caption-attachment-29963\" class=\"wp-caption-text\">Figure 3. Examples of constant-rate infusion pumps used for total intravenous anesthesia delivered via Practivet (<a href=\"http:\/\/practivet.com\" target=\"_blank\" rel=\"noopener\">practivet.com<\/a>).<\/p><\/div>\n<h3 class=\"p4\">Anesthesia Monitoring<\/h3>\n<p class=\"p2\"><span class=\"s1\">Monitoring should include ECG, pulse oximetry, blood pressure, capnography, and temperature measurements. For respiratory-compromised patients, arterial blood gas monitoring may be helpful; trends and abrupt changes will alert the anesthetist to changes in patient stability and the need for swift intervention.<\/span><\/p>\n<h3 class=\"p4\">Electrocardiography<\/h3>\n<p class=\"p6\"><b>Ventricular Tachycardia<\/b><\/p>\n<p class=\"p2\"><span class=\"s1\">Critically ill canine patients are at risk for sudden development of fatal arrhythmias. Ventricular tachycardia requires quick intervention with an appropriate antiarrhythmic (e.g., 2 mg\/kg lidocaine bolus).<\/span><\/p>\n<p class=\"p6\"><b>Ventricular Arrhythmias<\/b><\/p>\n<p class=\"p2\"><span class=\"s1\">Ventricular arrhythmias associated with hypotension should also be addressed; a lidocaine CRI may help control this arrhythmia while also providing analgesia and free radical scavenging.<\/span><\/p>\n<p class=\"p6\"><b>Premature Ventricular Contractions<\/b><\/p>\n<p class=\"p2\"><span class=\"s1\">Premature ventricular contractions are common in the critical-care patient but, unless associated with tachycardia or hypotension, do not always require intervention.<\/span><\/p>\n<p class=\"p6\"><b>Tachycardia<\/b><\/p>\n<p class=\"p2\"><span class=\"s1\">Tachycardia in the critical-care patient may be secondary to inappropriate anesthetic depth or analgesic control. Thus, care should be taken to prevent deep anesthetic planes. In addition, sinus tachycardia may be a compensatory response to hypovolemia and hypotension, which should be corrected with fluid therapy and blood product replacement.<\/span><\/p>\n<p class=\"p6\"><b>Bradyarrhythmias<\/b><\/p>\n<p class=\"p2\"><span class=\"s1\">Bradyarrhythmias are more common in feline patients and should be addressed with an anticholinergic (e.g., glycopyrrolate, atropine). Glycopyrrolate (0.011 mg\/kg IV) has a slower onset but longer duration of action and can be used to address mild bradycardia. Atropine (0.02 to 0.04 mg\/kg IV) has a faster onset and shorter duration of action and should be used for critical emergency bradycardia.<sup>18<\/sup><\/span><\/p>\n<h3 class=\"p4\">Pulse Oximetry<\/h3>\n<p class=\"p2\"><span class=\"s1\">For patients receiving 100% oxygen, the pulse oximetry reading should be 100%. However, pulse oximetry is often inaccurate in the critical-care patient due to weak pulses and hypotension. Because of inaccuracies of pulse oximeters in the critical-care patients, the anesthetist should also monitor oxygen delivery parameters (e.g., mucous membrane color, capillary refill time). Even in the event of inaccurate readings, the pulse oximeter can be used to monitor response to therapy. Identifying trends in the critical-care patient may be beneficial as abrupt changes in the pulse oximetry readings may indicate imminent cardiac arrest or severe hypotension.<\/span><\/p>\n<h3 class=\"p4\">Blood Pressure Monitoring<\/h3>\n<p class=\"p2\"><span class=\"s1\">Hypotension in anesthetized critical-care patients is common. Blood pressure should be monitored closely, and when needed, MAP should be swiftly restored to &gt;60 mm Hg. Fluid boluses of 5 mL\/kg may be administered over a 5-minute period to determine whether hypotension is responsive to fluid therapy (and thus secondary to hypovolemia). If normotension is achieved but short-lived after a fluid bolus, higher fluid rates may be beneficial. A dose of hypertonic saline may be administered to draw fluids into the intravascular space from the interstitial space. Colloids (e.g., FFP) can be administered to increase intravascular volume and may be preferred over large-volume fluid resuscitation.<sup>1<\/sup> Hypotension secondary to hemorrhage should be controlled with administration of pRBCs. Monitoring blood loss during surgery can be helpful for determining rate and quantity of blood product administration.<\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">For patients experiencing continued or severe hypotension, vasopressors should be administered to prevent MAP from falling below 60 mm Hg and risking acute kidney injury.<\/span><\/p>\n<h3 class=\"p4\">Capnography and Ventilatory Support<\/h3>\n<p class=\"p2\"><span class=\"s1\">The most important piece of monitoring equipment available for the critical-care patient\u2019s anesthetist may be the capnograph. Although other forms of monitoring equipment may be prone to error, the capnograph reading provides accurate, real-time insight as to the patient\u2019s ventilatory and cardiovascular status. Abruptly decreased Etco<sub>2<\/sub> should immediately alert the anesthetist to imminent cardiopulmonary arrest. High Etco<sub>2<\/sub> readings can indicate hypoventilation, and the anesthetist should provide ventilatory support via PPV. If already providing ventilatory support, increasing the respiratory rate and\/or tidal volume will help return the Etco<sub>2<\/sub> to normal.<\/span><\/p>\n<p class=\"p6\"><b>Positive-Pressure Ventilation<\/b><\/p>\n<p class=\"p2\"><span class=\"s1\">PPV is delivered primarily by using a surgical ventilator, although in the absence of a ventilator, PPV can be performed manually. Surgical ventilators connect to the anesthesia machine and use the anesthetic gas, oxygen, and tubing to deliver positive-pressure breaths to the patient. Positive-pressure breaths are delivered by increased pressure in the ventilator forcing air into the patient\u2019s lungs. That process differs from a natural patient-initiated breath, in which the diaphragm and intercostal muscles move to cause decreased pleural pressure and consequently decreased alveolar pressure to below atmospheric pressure, causing air to enter the lungs.<sup>19<\/sup> <\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Each positive-pressure breath increases intrathoracic pressure, which can decrease venous return. Decreased venous return equals decreased stroke volume, which means decreased cardiac output (stroke volume times heart rate) and potentially decreased blood pressure, particularly in the already hemodynamically compromised patient.<sup>20<\/sup> Thus, for hypotensive patients, peak inspiratory pressures should be lowered and the expiratory phase should be prolonged. <\/span><span class=\"s2\"><b>TABLE 4<\/b><\/span><span class=\"s1\"> and <\/span><span class=\"s2\"><b>FIGURE 4<\/b><\/span><span class=\"s1\"> show suggested initial ventilator settings.<\/span><\/p>\n<div id=\"attachment_29969\" style=\"width: 412px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-29969\" class=\" wp-image-29969\" src=\"https:\/\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Table4-1.png\" alt=\"\" width=\"402\" height=\"141\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Table4-1.png 966w, https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Table4-1-300x105.png 300w, https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Table4-1-768x270.png 768w\" sizes=\"(max-width: 402px) 100vw, 402px\" \/><p id=\"caption-attachment-29969\" class=\"wp-caption-text\"><span style=\"color: #ffffff\">.<\/span><\/p><\/div>\n<div id=\"attachment_29964\" style=\"width: 360px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-29964\" class=\" wp-image-29964\" src=\"https:\/\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Fig4-1.png\" alt=\"\" width=\"350\" height=\"467\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Fig4-1.png 720w, https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Fig4-1-225x300.png 225w\" sizes=\"(max-width: 350px) 100vw, 350px\" \/><p id=\"caption-attachment-29964\" class=\"wp-caption-text\">Figure 4. Surgical ventilator used for positive-pressure ventilation during anesthesia.<\/p><\/div>\n<p class=\"p6\"><b>Positive End-Expiratory Pressure<\/b><\/p>\n<p class=\"p2\"><span class=\"s1\">For patients in which ventilation is sufficient but pulse oximetry numbers are low despite adequate oxygen delivery, adding a positive end-expiratory pressure (PEEP) valve may be considered. Recumbent patients are likely to be predisposed to compression atelectasis and thus experience a ventilation\/perfusion mismatch.<sup>21<\/sup> Ventilation\/perfusion mismatch is caused when areas of the lungs are not ventilated (alveoli are not receiving air) but are perfused (alveolar capillaries are receiving blood), leading to sections of desaturated blood being shunted past the lungs and back to the heart. <\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">In addition to compression atelectasis, patients receiving a high fraction of inspired oxygen (e.g., those being administered 100% oxygen) may also experience absorption atelectasis.<sup>21<\/sup> Absorption atelectasis results from the alveoli being flooded with a high fraction of inspired oxygen, causing increased oxygen pressure in the alveoli and thus faster absorption from the alveoli into the pulmonary capillaries. Collapse occurs when this rate is faster than alveolar refilling. <\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Both compression and resorption atelectasis can be treated with use of a PEEP valve. PEEP valves prevent airway pressure from reaching 0 and prevent alveolar collapse by maintaining a positive airway pressure, thus allowing more alveoli to participate in gas exchange. High levels of PEEP hinder CO<sub>2<\/sub> exchange and may lead to alveolar overdistension in non\u2013gravity-dependent alveoli. A PEEP of 2.5 to 5 cm H<sub>2<\/sub>O is usually sufficient for alveolar recruitment, except for patients with severe pulmonary disease.<\/span><\/p>\n<h3 class=\"p4\">Temperature<\/h3>\n<p class=\"p2\"><span class=\"s1\">The critical-care patient is particularly prone to loss of thermostatic regulation and to hypothermia. Controlling hypothermia will require multiple warming measures (e.g., warming blanket devices [HotDog, <\/span><span class=\"s2\">hotdogwarming.com<\/span><span class=\"s1\">; Bair hugger, <\/span><span class=\"s2\">bairhugger.com<\/span><span class=\"s1\">], fluid warmers, limb insulation devices such as socks and plastic wrap, warm lavage fluids). Recovery of hypothermic patients will be slow, and oxygen offload in peripheral tissues may be impaired.<\/span><\/p>\n<h3 class=\"p4\">Cardiopulmonary Arrest<\/h3>\n<p><em>Note: The 2024 RECOVER (Reassessment Campaign on Veterinary Resuscitation) cardiopulmonary resuscitation (CPR) guidelines no longer recommend high-dose epinephrine (0.1 mg\/kg) at any point during CPR for dogs and cats. Because this article was written and published prior to the release of this update,\u00a0\u00a0it does not reflect that change. Learn more about the 2024 RECOVER CPR guidelines <a href=\"https:\/\/todaysveterinarynurse.com\/emergency-medicine-critical-care\/updates-from-the-2024-recover-guidelines\/\" target=\"_blank\" rel=\"noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/todaysveterinarynurse.com\/emergency-medicine-critical-care\/updates-from-the-2024-recover-guidelines\/&amp;source=gmail&amp;ust=1770414379151000&amp;usg=AOvVaw00Fo6sgcvV-gO6JhgXc6wr\">here<\/a>.<\/em><\/p>\n<p class=\"p2\"><span class=\"s1\">Cardiopulmonary arrest is often preceded by a sudden development of an arrhythmia and rapid decline in Etco<sub>2<\/sub>. When arrest or impending arrest is suspected, RECOVER (Reassessment Campaign on Veterinary Resuscitation, <\/span><a href=\"http:\/\/recoverinitiative.org\" target=\"_blank\" rel=\"noopener\"><span class=\"s2\">recoverinitiative.org<\/span><\/a><span class=\"s1\">) guidelines should be followed.<sup>22<\/sup> All anesthetic agents should be ceased; inhalant gas should be turned to 0, and CRI pumps should be stopped. If performing abdominal surgery, the surgeon can pierce the diaphragm and begin direct cardiac compressions. If PPV is not being administered, it should be initiated at 10 breaths\/min to 20 cm H<sub>2<\/sub>O pressure. The emergency drugs epinephrine and atropine should be given intravenously, quickly followed by emergency reversal agents; opioids are reversed with naloxone, and benzodiazepines are reversed with flumazenil (<\/span><span class=\"s2\"><b>TABLE\u00a05<\/b><\/span><span class=\"s1\">). Survival to discharge is reported to be as high as 47% for patients <\/span>that underwent anesthetic death; thus, cardiopulmonary<span class=\"s1\"> resuscitation efforts should be conducted according to clients\u2019 wishes until all efforts have been exhausted.<sup>22<\/sup><\/span><\/p>\n<div id=\"attachment_29970\" style=\"width: 411px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-29970\" class=\" wp-image-29970\" src=\"https:\/\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Table5-1.png\" alt=\"\" width=\"401\" height=\"209\" srcset=\"https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Table5-1.png 973w, https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Table5-1-300x156.png 300w, https:\/\/navc.sitepreview.app\/todaysveterinarynurse.com\/wp-content\/uploads\/sites\/3\/2023\/11\/Lyons_TVNWinter24_CriticalCareAnesthesia_Table5-1-768x400.png 768w\" sizes=\"(max-width: 401px) 100vw, 401px\" \/><p id=\"caption-attachment-29970\" class=\"wp-caption-text\"><span style=\"color: #ffffff\">.<\/span><\/p><\/div>\n<h2 class=\"p3\">Postoperative Period<\/h2>\n<p class=\"p2\"><span class=\"s1\">The second potentially most critical period for the critical anesthetized patient is recovery. Cardiopulmonary arrest can rapidly occur if monitoring, oxygen support, and CRIs are discontinued as the patient is moved from the surgical suite to the recovery location. Complications can be minimized if the patient fully recovers and is extubated while in the surgical suite. Use of mobile IV poles to continue running supportive fluids and CRIs and, if available, mobile anesthesia monitoring equipment is also recommended. Performing a recheck minimum database during the postoperative period will help guide continued clinical decisions.<\/span><\/p>\n<h2 class=\"p3\">Summary<\/h2>\n<p class=\"p2\"><span class=\"s1\">Anesthetizing critical-care patients requires diligence and knowledge. Preparing and anticipating intraoperative complications will lead to swift response times and better patient outcomes.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>This article provides a thorough, multimodal approach for how to support the critical-care patient through the pre-, peri-, and postoperative anesthetic 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